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Protein Overview: mek1

General Information:
Name(s) found: mek1 / SPAC14C4.03 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • Cds1/Rad53/Chk2 family protein kinase Mek1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 445 amino acids

    Gene Ontology:
    Cellular Component: linear element [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: meiotic recombination checkpoint [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of linear element assembly [IGILink to PubMed article]
    protein amino acid phosphorylation [ISSLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    protein serine/threonine kinase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFLSHAMLS RSESTQILCE LSQIDESTMD PQYTEDDVLA RLFVFSSSSP QTVLNVKKYE  60
   61 DVSVGRSNTC NYQLLQFTAS YKHFRVYSVL IDDDMDPLVY CEDQSSNGTF LNHRLIGKGN 120
  121 SVLLSDGDIL DVRHCASFLF QQKYTTDNDF HHEYAGERFN ITQRLLGIGG FSRIYMAMDN 180
  181 NTGGQYACKI IDKKKISTKR FFEDHEMTIL RKLDHPNIIK VNMEYNSETQ FFIFEEMVTG 240
  241 GDLFSYLTKL GTVPEVTTLF IMFQILQGLK YLHEQNIIHR DLKLENILIA SSSDTIFRII 300
  301 LTDFGVARCM QKGKRLSTFV GTPEYTAPEI QRLKGRSQVE KENSSGYGKE VDLWSLGVIM 360
  361 FLLLSGNSPS FADGVKEKQV DFRDPVWKSV SRQAKDLISN LLKTNPPDRF TVKQCLSHPW 420
  421 FARHSSRLTK LYETRILKPL KHSRL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..156] FFAS03 5.08 Phosphotyrosine binding domain of Rad53
    2 View Details [157..445] PSI-BLAST 70.0 No description for 2jc6A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  3.49130250684713 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.13020166288045 bayes_pls_golite062009
  • DNA binding
    		•  2.99552004033076 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.81220637832811 bayes_pls_golite062009
  • protein binding
    		•  2.20369144716037 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  2.16945817502942 bayes_pls_golite062009
  • histone binding
    		•  1.9804501088198 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  1.86981735398675 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.86962688291741 bayes_pls_golite062009
  • kinase activity
    		•  1.81862841628054 bayes_pls_golite062009
  • transcription factor activity
    		•  1.81518687735417 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.80379362156554 bayes_pls_golite062009
  • protein kinase activity
    		•  1.71310411241427 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.66136286081439 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.64875926701369 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.58636372907213 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.52097696229253 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  1.4597324111121 bayes_pls_golite062009
  • transcription activator activity
    		•  1.37559643803178 bayes_pls_golite062009
  • transferase activity
    		•  1.31313779244307 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.28748237525351 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  1.14082165984579 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  0.833789957086181 bayes_pls_golite062009
  • transcription factor binding
    		•  0.820790849849904 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  0.804599000027271 bayes_pls_golite062009
  • promoter binding
    		•  0.752181947431975 bayes_pls_golite062009
  • signal transducer activity
    		•  0.597728117940736 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.597728117940736 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.449808058396269 bayes_pls_golite062009
  • SMAD binding
    		•  0.442971472842983 bayes_pls_golite062009
  • chromatin binding
    		•  0.434019593940368 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.354750697429 bayes_pls_golite062009
  • R-SMAD binding
    		•  0.18488905369604 bayes_pls_golite062009
  • damaged DNA binding
    		•  0.182219412947843 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle