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Protein Overview: ceg1

General Information:
Name(s) found: ceg1 / SPBC2F12.08c [Sanger Pombe]
Description(s) found:
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  • pir||T40133 mRNA guanylyltransferase (EC 2.7.7.50) [validated] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|729998|sp|P40997.1|MCE1_SCHPO RecName: Full=mRNA-capping enzyme subunit alpha; AltName: Full=mRNA guanylyltransferase; AltName: Full=GTP--RNA guanylyltransferase; Short=GTase [NCBI NR]
  • gi|609362|gb|AAA58715.1| GTP--RNA guanylytransferase [NCBI NR]
  • gi|562123|gb|AAA64996.1| GTP:RNA guanylyltransferase [NCBI NR]
  • gi|2239238|emb|CAB10156.1| mRNA guanylyltransferase Ceg1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112500|ref|NP_595708.1| mRNA guanylyltransferase Ceg1 [Schizosaccharomyces pombe] [NCBI NR]
  • mRNA guanylyltransferase Ceg1 [Sanger Pombe]
  • mRNA-capping enzyme subunit alpha OS=Schizosaccharomyces pombe GN=ceg1 PE=1 SV=1 [Swiss-Prot]
  • MRNA CAPPING ENZYME; MRNA GUANYLYLTRANSFERASE; SIMILAR TO S. CEREVISIAE CEG1: P40997; [pompepVF.fasta]
  • mRNA capping enzyme alpha subunit (mRNA guanylyltransferase) (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase) [pompep4896]
  • |ceg1|pce1|mRNA capping enzyme [pompepnew.fasta]
  • |ceg1|pce1|mRNA guanylyltransferase|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • mrna capping enzyme, mrna guanylyltransferase [Schizosaccharomyces pombe]gi|2239238|emb|CAB10156.1| ceg1 [Schizosaccharomyces pombe]gi|7492204|pir||T40133 mRNA guanylyltransferase (EC 2.7.7.50) [validated] - fission yeast (Schizosaccharomyces pombe)gi| [nrdb_11152004_Chlamydomonas]
  • (P40997) mRNA capping enzyme alpha subunit (mRNA guanylyltransferase) (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase) [pompep4896_normal_reversed]
  • |ceg1|pce1|mRNA guanylyltransferase Ceg1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • GTP:RNA guanylyltransferase [nr-271106-contam.fasta]
  • GTP--RNA guanylytransferase [nr-271106-contam.fasta]
  • hypothetical protein SPBC2F12.08c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC2F12.08c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • mRNA capping enzyme subunit alpha (mRNA guanylyltransferase) (GTP--RNA guanylyltransferase) (GTase) [nr-271106-contam.fasta]
  • mRNA-capping enzyme subunit alpha OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ceg1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 402 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    mRNA cap methyltransferase complex [ISSLink to PubMed article]
    Biological Process: mRNA capping [ISSLink to PubMed article]
    Molecular Function: GTP binding [IEA]
    protein binding [IPILink to PubMed article]
    mRNA guanylyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAPSEKDIEE VSVPGVLAPR DDVRVLKTRI AKLLGTSPDT FPGSQPVSFS KKHLQALKEK  60
   61 NYFVCEKSDG IRCLLYMTEH PRYENRPSVY LFDRKMNFYH VEKIFYPVEN DKSGKKYHVD 120
  121 TLLDGELVLD IYPGGKKQLR YLVFDCLACD GIVYMSRLLD KRLGIFAKSI QKPLDEYTKT 180
  181 HMRETAIFPF LTSLKKMELG HGILKLFNEV IPRLRHGNDG LIFTCTETPY VSGTDQSLLK 240
  241 WKPKEMNTID FMLKLEFAQP EEGDIDYSAM PEFQLGVWEG RNMYSFFAFM YVDEKEWEKL 300
  301 KSFNVPLSER IVECYLDDEN RWRFLRFRDD KRDANHISTV KSVLQSIEDG VSKEDLLKEM 360
  361 PIIREAYYNR KKPSVTKRKL DETSNDDAPA IKKVAKESEK EI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..402] PSI-BLAST 65.0 mRNA capping enzyme alpha subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mRNA guanylyltransferase activity
    		•  8.90512192081791 bayes_pls_golite062009
  • RNA guanylyltransferase activity
    		•  8.46124967325993 bayes_pls_golite062009
  • ligase activity, forming phosphoric ester bonds
    		•  2.90848936326491 bayes_pls_golite062009
  • DNA ligase activity
    		•  2.88630907730339 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.49304224824605 bayes_pls_golite062009
  • ligase activity
    		•  2.44151794329612 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • DNA binding
    		•  2.3408239279957 bayes_pls_golite062009
  • catalytic activity
    		•  2.15370807854636 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.10110937001387 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.9581702424972 bayes_pls_golite062009
  • binding
    		•  1.82998145778732 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  1.64088197294498 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.51215866188241 bayes_pls_golite062009
  • protein binding
    		•  1.38006517521813 bayes_pls_golite062009
  • transcription activator activity
    		•  1.24141936405635 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.19236946227657 bayes_pls_golite062009
  • structural molecule activity
    		•  1.16496993393687 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  1.15212468568198 bayes_pls_golite062009
  • transcription factor activity
    		•  1.14242112812892 bayes_pls_golite062009
  • exoribonuclease activity
    		•  1.10445667068538 bayes_pls_golite062009
  • DNA ligase (ATP) activity
    		•  1.02324195596817 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  0.83268201349295 bayes_pls_golite062009
  • DNA ligase (NAD+) activity
    		•  0.802565778478831 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.583085644017496 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • translation regulator activity
    		•  0.515576958825022 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.510809870824979 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.510809870824979 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.468402630523277 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.2080607201312 bayes_pls_golite062009
  • chromatin binding
    		•  0.19409870825073 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle