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Protein Overview: clp1

General Information:
Name(s) found: clp1 / SPAC1782.09c [Sanger Pombe]
Description(s) found:
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  • gi|7160233|emb|CAB76271.1| Cdc14-related protein phosphatase Clp1/Flp1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|26393807|sp|Q9P7H1.1|CLP1_SCHPO RecName: Full=Tyrosine-protein phosphatase CDC14 homolog; AltName: Full=CDC fourteen-like phosphatase 1 [NCBI NR]
  • gi|19115628|ref|NP_594716.1| Cdc14-related protein phosphatase Clp1/Flp1 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||T50099 probable protein-tyrosine phosphatase CDC14 homolog [imported] - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • Cdc14-related protein phosphatase Clp1/Flp1 [Sanger Pombe]
  • Tyrosine-protein phosphatase CDC14 homolog OS=Schizosaccharomyces pombe GN=clp1 PE=1 SV=1 [Swiss-Prot]
  • DUAL SPECIFICITY PROTEIN-TYROSINE PHOSPHATASE (PTPASE); INVOLVED IN SEPTATION; NULL VIABLE; NULL MUTANT DIVIDES AT REDUCED SIZE; NULL MUTANT SHOWS DEFECTS IN SEPTATION; MAY POTENTIATE SIGNALLING OF THE ONSET OF SEPTATION; SIMILAR TO S. CEREVISIAE CDC14 [pompepVF.fasta]
  • PUTATIVE DUAL SPECIFICITY PROTEIN-TYROSINE PHOSPHATASE (PTPASE); POSSIBLY S PHASE: Q9P7H1; [pompepV13]
  • Protein-tyrosine phosphatase CDC14 homolog (EC 3.1.3.48) (CDC fourteen-like phosphatase 1) [pompep4896]
  • |flp1|clp1|dual specificity protein-tyrosine phosphatase (PTPase) [pompepnew.fasta]
  • |clp1|flp1|protein-tyrosine phosphatase|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • probable protein-tyrosine phosphatase CDC14 homolog [Schizosaccharomyces pombe]gi|7160233|emb|CAB76271.1| SPAC1782.09c [Schizosaccharomyces pombe]gi|26393807|sp|Q9P7H1|FLP1_SCHPO Protein-tyrosine phosphatase CDC14 homolog (CDC fourteen-like phosphatase [nrdb_11152004_Chlamydomonas]
  • |flp1|clp1|Cdc14-related protein phosphatase|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q9P7H1) Protein-tyrosine phosphatase CDC14 homolog (EC 3.1.3.48) (CDC fourteen-like phosphatase 1) [pompep4896_normal_reversed]
  • |clp1|flp1|Cdc14-related protein phosphatase Clp1/Flp1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Tyrosine-protein phosphatase CDC14 homolog (CDC fourteen-like phosphatase 1) [nr-271106-contam.fasta]
  • SPAC1782.09c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC1782.09c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Tyrosine-protein phosphatase CDC14 homolog OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=clp1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 537 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    spindle midzone [IDALink to PubMed article]
    actomyosin contractile ring [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    spindle pole body [IDALink to PubMed articleLink to PubMed article]
    condensed chromosome kinetochore [IDALink to PubMed article]
    nucleolus [IDALink to PubMed article]
    Biological Process: barrier septum formation [IMPLink to PubMed article]
    G2/M transition of mitotic cell cycle [IMPLink to PubMed article]
    positive regulation of septation initiation signaling [TASLink to PubMed article]
    regulation of exit from mitosis [IMPLink to PubMed article]
    attachment of spindle microtubules to kinetochore [IGILink to PubMed article]
    protein amino acid dephosphorylation [ICLink to PubMed article]
    sister chromatid biorientation [IMPLink to PubMed article]
    mitotic sister chromatid segregation [IMPLink to PubMed article]
    negative regulation of cyclin-dependent protein kinase activity [IGILink to PubMed article]
    cellular protein localization [IGILink to PubMed article]
    cytokinesis checkpoint [IMPLink to PubMed article]
    contractile ring maintenance involved in cell cycle cytokinesis [IMPLink to PubMed article]
    Molecular Function: phosphoprotein phosphatase activity [IDALink to PubMed article]
    phosphoprotein phosphatase inhibitor activity [IGILink to PubMed article]
    protein binding [IPILink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    protein tyrosine phosphatase activity [IEA]
    protein tyrosine/serine/threonine phosphatase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDYQDDGLGE MIEFLEDKLY YTSLSQPPKA ELYPHMHFFT IDDELIYNPF YHDFGPLNVS  60
   61 HLIRFAVIVH GIMGKHRQAK KSKAIVLYSS TDTRLRANAA CLLACYMVLV QNWPPHLALA 120
  121 PLAQAEPPFL GFRDAGYAVS DYYITIQDCV YGLWRARESS ILNIRNIDVH DYETYERVEN 180
  181 GDFNWISPKF IAFASPIQAG WNHASTRPKK LPQPFAIVLD YFVANKVKLI VRLNGPLYDK 240
  241 KTFENVGIRH KEMYFEDGTV PELSLVKEFI DLTEEVEEDG VIAVHCKAGL GRTGCLIGAY 300
  301 LIYKHCFTAN EVIAYMRIMR PGMVVGPQQH WLHINQVHFR AYFYEKAMGR AIQQATAAEP 360
  361 LATPPRHPLN ATNGTSQSNI STPLPEPTPG QPRKVSGHNP PSARRLPSAS SVKFNEKLKN 420
  421 ASKQSIQNEN KASYSSYEDS EIQNDDETRT VGTPTETISV VRLRRSSSQS NIEPNGVRSP 480
  481 TSSPTGSPIR RTSGNRWSSG SSHSKKSAQR SVSMSSLNNT SNGRVAKPKP SKSRLIS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..359] PSI-BLAST 108.0 Proline directed phosphatase CDC14b2
    2 View Details [360..537] MSA 4.176997 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.30669036331612 bayes_pls_golite062009
  • phosphatase activity
    		•  6.6585143972081 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.44546424348532 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.70473199778334 bayes_pls_golite062009
  • protein tyrosine phosphatase activity
    		•  5.3097342170423 bayes_pls_golite062009
  • alpha-actinin binding
    		•  3.03868073080583 bayes_pls_golite062009
  • actin binding
    		•  2.96334024905854 bayes_pls_golite062009
  • transmembrane receptor protein phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine phosphatase activity
    		•  2.94635032478625 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.93073637718155 bayes_pls_golite062009
  • protein tyrosine/serine/threonine phosphatase activity
    		•  2.77531895423367 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  2.49496709551693 bayes_pls_golite062009
  • protein binding
    		•  2.12487185456363 bayes_pls_golite062009
  • binding
    		•  2.06015698112379 bayes_pls_golite062009
  • hydrolase activity
    		•  1.9069800114411 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.24416639415232 bayes_pls_golite062009
  • DNA binding
    		•  1.19665037078743 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphatase activity
    		•  1.1200449509328 bayes_pls_golite062009
  • catalytic activity
    		•  1.06283028154109 bayes_pls_golite062009
  • lipid phosphatase activity
    		•  1.05085928819585 bayes_pls_golite062009
  • phosphoprotein phosphatase inhibitor activity
    		•  0.979874859714334 bayes_pls_golite062009
  • non-membrane spanning protein tyrosine phosphatase activity
    		•  0.724257798127697 bayes_pls_golite062009
  • transporter activity
    		•  0.653544405131346 bayes_pls_golite062009
  • phosphatase inhibitor activity
    		•  0.64132831041331 bayes_pls_golite062009
  • protein kinase activity
    		•  0.569334963316149 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.401311298433519 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.386515379888428 bayes_pls_golite062009
  • kinase activity
    		•  0.380629891538418 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.343848090522899 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.291525352733402 bayes_pls_golite062009
  • receptor activity
    		•  0.191946218805025 bayes_pls_golite062009
  • enzyme binding
    		•  0.150910330021054 bayes_pls_golite062009
  • kinase binding
    		•  0.141802531311128 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.09373220143933 bayes_pls_golite062009
  • protein kinase binding
    		•  0.062562314598915 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.85

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle