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A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed. A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components. A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum. Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells. Any process that modulates the rate or extent of progression through the cell cycle. The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage. Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.

View Gene Ontology (GO) Term

GO TERM SUMMARY

Name: cytokinesis checkpoint
Acc: GO:0031565
Aspect: Biological Process
Desc: A cell cycle checkpoint that ensures the correct temporal ordering of nuclear division and cytokinesis; arrests the cell cycle in G2 upon perturbation of cytokinetic structures. In Schizosaccharomyces, the checkpoint monitors formation and integrity of medial actomyosin ring and septum.
Synonyms:
  • contractile ring checkpoint
Proteins in PDR annotated with:
   This term: 3 [Search]
   Term or descendants: 11 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0031565 - cytokinesis checkpoint (interactive image map)

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