Protein Overview: exo1

General Information:
Name(s) found:	exo1 / SPBC29A10.05 [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	gi\|703466\|gb\|AAC41648.1\| exonuclease [Schizosaccharomyces pombe] [NCBI NR] gi\|4007793\|emb\|CAA22433.1\| exonuclease I Exo1 [Schizosaccharomyces pombe] [NCBI NR] gi\|19112842\|ref\|NP_596050.1\| exonuclease I Exo1 [Schizosaccharomyces pombe] [NCBI NR] gi\|1706728\|sp\|P53695.1\|EXO1_SCHPO RecName: Full=Exodeoxyribonuclease 1; AltName: Full=Exodeoxyribonuclease I; Short=Exonuclease I; Short=EXO I [NCBI NR] pir\|\|T43288 probable exodeoxyribonuclease I (EC 3.1.11.1) - fission yeast (Schizosaccharomyces pombe) [NCBI NR] exonuclease I Exo1 [Sanger Pombe] Exodeoxyribonuclease 1 OS=Schizosaccharomyces pombe GN=exo1 PE=1 SV=1 [Swiss-Prot] EXONUCLEASE I; MISMATCH REPAIR; 5'-3' EXONUCLEASE; SIMILAR TO S. CEREVISAE EXO1: P53695; [pompepVF.fasta] EXONUCLEASE I; MISMATCH REPAIR; 5'-3' EXONUCLEASE: P53695; [pompepV13] Exonuclease I (EXO I) [pompep4896] \|exo1\|\|exonuclease I [pompepnew.fasta] Exodeoxyribonuclease I (EC 3.1.11.-) (Exonuclease I) (EXO I) [4896.FASTAC] \|exo1\|\|exonuclease\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] \|exo1\|\|exonuclease i\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] exonuclease i [Schizosaccharomyces pombe]gi\|4007793\|emb\|CAA22433.1\| exo1 [Schizosaccharomyces pombe]gi\|1706728\|sp\|P53695\|EXO1_SCHPO Exodeoxyribonuclease I (Exonuclease I) (EXO I)gi\|703466\|gb\|AAC41648.1\| exonucleasegi\|11359238\|pir\|\|T43288 probable exod [nrdb_11152004_Chlamydomonas] (P53695) Exonuclease I (EXO I) [pompep4896_normal_reversed] \|exo1\|mut2\|exonuclease I Exo1\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta] exonuclease [nr-271106-contam.fasta] Exodeoxyribonuclease 1 (Exodeoxyribonuclease I) (Exonuclease I) (EXO I) [nr-271106-contam.fasta] SPBC29A10.05 [Schizosaccharomyces pombe] [nr-271106-contam.fasta] hypothetical protein SPBC29A10.05 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] Exodeoxyribonuclease 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=exo1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	571 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][ISS] spindle [IDA]
Biological Process:	maintenance of DNA repeat elements [IMP] meiotic DNA double-strand break processing [TAS] telomere maintenance [TAS] mismatch repair [IGI][IMP] mitotic recombination [TAS]
Molecular Function:	5'-3' exonuclease activity [IMP] magnesium ion binding [IEA] 5'-flap endonuclease activity [ISS] double-stranded DNA binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIKGLLGLL KPMQKSSHVE EFSGKTLGVD GYVWLHKAVF TCAHELAFNK ETDKYLKYAI  60
   61 HQALMLQYYG VKPLIVFDGG PLPCKASTEQ KRKERRQEAF ELGKKLWDEG KKSQAIMQFS 120
  121 RCVDVTPEMA WKLIIALREH GIESIVAPYE ADAQLVYLEK ENIIDGIITE DSDMLVFGAQ 180
  181 TVLFKMDGFG NCITIRRNDI ANAQDLNLRL PIEKLRHMAI FSGCDYTDGV AGMGLKTALR 240
  241 YLQKYPEPRA AIRAMRLDKS LKVPVSFEKE FALADLAFRH QRVYCPKDKT LVHLSPPERE 300
  301 LSVHEDAFIG SFFDNQLAID IAEGRSNPIT KCAFDIKDSS MQSFTKTTIT ISKRKGISKT 360
  361 DISNFFMKSI PPSKRPTKST SLIDVTNVKV QRTHLANDIS SEKQSIKSAN EKAYVTPKSN 420
  421 SLKPGFGKSL SDISNSATKN ENVPFLPPRT GVSKYFKLQK NTEKEIDEQV PSQSNNTTPT 480
  481 SAKSDSASPQ NWFSSFSYQT PNSASPPFSS LSHTLPISAL AKIGHDALNR KNHASLPSRR 540
  541 IVYKPPSSPS TPISMNPRPK GILSLQQYKF R

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

Term	Confidence	Notes
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	4.19173394038227	bayes_pls_golite062009
flap endonuclease activity	4.10438637013244	bayes_pls_golite062009
exonuclease activity	3.55065728618765	bayes_pls_golite062009
endonuclease activity	3.40075034200919	bayes_pls_golite062009
endodeoxyribonuclease activity	3.29138075959109	bayes_pls_golite062009
deoxyribonuclease activity	3.25110450559975	bayes_pls_golite062009
5'-3' exonuclease activity	3.19536858640519	bayes_pls_golite062009
hydrolase activity	2.92353053808585	bayes_pls_golite062009
nuclease activity	2.50181033811809	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.45364009363271	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2.3324415860722	bayes_pls_golite062009
5'-3' exodeoxyribonuclease activity	2.26658239783943	bayes_pls_golite062009
double-stranded DNA specific exodeoxyribonuclease activity	2.09057967200253	bayes_pls_golite062009
exodeoxyribonuclease activity	2.0005433655378	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	1.9833086883205	bayes_pls_golite062009
binding	1.86985246794396	bayes_pls_golite062009
5'-flap endonuclease activity	1.81850767854435	bayes_pls_golite062009
DNA binding	1.67328600485167	bayes_pls_golite062009
nucleic acid binding	1.61574912542722	bayes_pls_golite062009
single-stranded DNA specific exodeoxyribonuclease activity	1.61167902830399	bayes_pls_golite062009
damaged DNA binding	1.42836853175021	bayes_pls_golite062009
catalytic activity	1.37534898662234	bayes_pls_golite062009
structure-specific DNA binding	1.16717206930423	bayes_pls_golite062009
single-stranded DNA specific 5'-3' exodeoxyribonuclease activity	1.15948049342759	bayes_pls_golite062009
single-stranded DNA specific endodeoxyribonuclease activity	1.10463550341524	bayes_pls_golite062009
endodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.901965019685213	bayes_pls_golite062009
protein binding	0.389020243587168	bayes_pls_golite062009
ribonuclease activity	0.198926730726347	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.176453677293411	bayes_pls_golite062009
double-stranded DNA binding	0.0978227645302046	bayes_pls_golite062009
3'-5'-exodeoxyribonuclease activity	0.0205129272358	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..385]	PSI-BLAST	73.69897	Crystal structure of the human FEN1-PCNA complex
2	View Details	[386..571]	PSI-BLAST	45.0	STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP

Protein Overview: exo1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: