Abstract
Exonuclease I (Exo I) from Schizosaccharomyces pombe, a 5'-->3' double-stranded DNA exonuclease, is induced during meiotic prophase I. The exo1 gene is a member of a family of related DNA repair genes, including RAD2/rad13/xpgc and YKL510/rad2, conserved from yeast to humans. An exo1 mutant displays a mutator phenotype and alters activity of the ade6-M387 marker effect. These results suggest that Exo I acts in a pathway that corrects mismatched base pairs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles
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Amino Acid Sequence
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Base Composition
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Base Sequence
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Crosses, Genetic
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DNA Repair*
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DNA Replication
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DNA, Fungal / metabolism*
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Exodeoxyribonucleases / chemistry
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Exodeoxyribonucleases / genetics
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Exodeoxyribonucleases / metabolism*
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Meiosis
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Molecular Sequence Data
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Mutation*
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Recombination, Genetic
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Schizosaccharomyces / enzymology
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Schizosaccharomyces / genetics*
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Schizosaccharomyces / physiology
Substances
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DNA, Fungal
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Exodeoxyribonucleases
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exodeoxyribonuclease I