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Protein Overview: exo1

General Information:
Name(s) found: exo1 / SPBC29A10.05 [Sanger Pombe]
Description(s) found:
Found 22 descriptions.
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  • exonuclease I Exo1 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 571 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article][ISSLink to PubMed article]
    spindle [IDALink to PubMed article]
    Biological Process: maintenance of DNA repeat elements [IMPLink to PubMed article]
    meiotic DNA double-strand break processing [TASLink to PubMed article]
    telomere maintenance [TASLink to PubMed article]
    mismatch repair [IGILink to PubMed article][IMPLink to PubMed article]
    mitotic recombination [TASLink to PubMed article]
    Molecular Function: 5'-3' exonuclease activity [IMPLink to PubMed article]
    magnesium ion binding [IEA]
    5'-flap endonuclease activity [ISSLink to PubMed article]
    double-stranded DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIKGLLGLL KPMQKSSHVE EFSGKTLGVD GYVWLHKAVF TCAHELAFNK ETDKYLKYAI  60
   61 HQALMLQYYG VKPLIVFDGG PLPCKASTEQ KRKERRQEAF ELGKKLWDEG KKSQAIMQFS 120
  121 RCVDVTPEMA WKLIIALREH GIESIVAPYE ADAQLVYLEK ENIIDGIITE DSDMLVFGAQ 180
  181 TVLFKMDGFG NCITIRRNDI ANAQDLNLRL PIEKLRHMAI FSGCDYTDGV AGMGLKTALR 240
  241 YLQKYPEPRA AIRAMRLDKS LKVPVSFEKE FALADLAFRH QRVYCPKDKT LVHLSPPERE 300
  301 LSVHEDAFIG SFFDNQLAID IAEGRSNPIT KCAFDIKDSS MQSFTKTTIT ISKRKGISKT 360
  361 DISNFFMKSI PPSKRPTKST SLIDVTNVKV QRTHLANDIS SEKQSIKSAN EKAYVTPKSN 420
  421 SLKPGFGKSL SDISNSATKN ENVPFLPPRT GVSKYFKLQK NTEKEIDEQV PSQSNNTTPT 480
  481 SAKSDSASPQ NWFSSFSYQT PNSASPPFSS LSHTLPISAL AKIGHDALNR KNHASLPSRR 540
  541 IVYKPPSSPS TPISMNPRPK GILSLQQYKF R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..385] PSI-BLAST 73.69897 Crystal structure of the human FEN1-PCNA complex
    2 View Details [386..571] PSI-BLAST 45.0 STRUCTURE OF LARGE FRAGMENT OF ESCHERICHIA COLI DNA POLYMERASE I COMPLEXED WITH D/TMP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  4.19173394038227 bayes_pls_golite062009
  • flap endonuclease activity
    		•  4.10438637013244 bayes_pls_golite062009
  • exonuclease activity
    		•  3.55065728618765 bayes_pls_golite062009
  • endonuclease activity
    		•  3.40075034200919 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  3.19536858640519 bayes_pls_golite062009
  • hydrolase activity
    		•  2.92353053808585 bayes_pls_golite062009
  • nuclease activity
    		•  2.50181033811809 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.45364009363271 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.3324415860722 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  2.26658239783943 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  2.09057967200253 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • binding
    		•  1.86985246794396 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.81850767854435 bayes_pls_golite062009
  • DNA binding
    		•  1.67328600485167 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.61574912542722 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  1.61167902830399 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.42836853175021 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.16717206930423 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  1.15948049342759 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  1.10463550341524 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.901965019685213 bayes_pls_golite062009
  • protein binding
    		•  0.389020243587168 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.198926730726347 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.176453677293411 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0978227645302046 bayes_pls_golite062009
  • 3'-5'-exodeoxyribonuclease activity
    		•  0.0205129272358 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle