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Protein Overview: nth1

General Information:
Name(s) found: nth1 / SPAC30D11.07 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • DNA endonuclease III [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 355 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    mitochondrial matrix [ISSLink to PubMed article]
    Biological Process: base-excision repair [IMPLink to PubMed article]
    base-excision repair, AP site formation [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: 5-formyluracil DNA N-glycosylase activity [IDALink to PubMed article]
    DNA binding [ISSLink to PubMed article]
    iron ion binding [IEA]
    endonuclease activity [IEA]
    5-hydroxymethyluracil DNA N-glycosylase activity [IDALink to PubMed article]
    oxidized pyrimidine base lesion DNA N-glycosylase activity [IMPLink to PubMed article]
    8-oxo-7,8-dihydroguanine DNA N-glycosylase activity [IDALink to PubMed article]
    4 iron, 4 sulfur cluster binding [IEA]
    iron-sulfur cluster binding [IEA]
    oxidized purine base lesion DNA N-glycosylase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKDYGTPPE NWREVYDEIC KMKAKVVAPV DVQGCHTLGE RNDPKKFRFQ TLVALMLSSQ  60
   61 TKDIVLGPTM RNLKEKLAGG LCLEDIQNID EVSLNKLIEK VGFHNRKTIY LKQMARILSE 120
  121 KFQGDIPDTV EDLMTLPGVG PKMGYLCMSI AWNKTVGIGV DVHVHRICNL LHWCNTKTEE 180
  181 QTRAALQSWL PKELWFELNH TLVGFGQTIC LPRGRRCDMC TLSSKGLCPS AFKEKSGITI 240
  241 TKRKVKTIKR VKKRPASESP PLSPLSLPTD DLYYQSIEDK SLIKLEDLDP VDSISHMNEP 300
  301 LKKEPAADID VDQKPPVAFH STTKETRSLR RSKRVAKKSS QYFSQQSLQD IEDLV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 56.221849 REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM
    2 View Details [218..355] PSI-BLAST 6.69897 Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA N-glycosylase activity
    		•  4.8124964619976 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing N-glycosyl compounds
    		•  4.26870112679392 bayes_pls_golite062009
  • DNA-(apurinic or apyrimidinic site) lyase activity
    		•  3.71152530486175 bayes_pls_golite062009
  • oxidized base lesion DNA N-glycosylase activity
    		•  2.49872706126491 bayes_pls_golite062009
  • hydrolase activity
    		•  2.39042189031819 bayes_pls_golite062009
  • 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
    		•  2.21048599823382 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  2.18053745735048 bayes_pls_golite062009
  • catalytic activity
    		•  2.13345932727422 bayes_pls_golite062009
  • alkylbase DNA N-glycosylase activity
    		•  1.5832578018127 bayes_pls_golite062009
  • DNA binding
    		•  1.44394874535958 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.36800347239439 bayes_pls_golite062009
  • oxidized purine base lesion DNA N-glycosylase activity
    		•  1.32985950765371 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.32391480975295 bayes_pls_golite062009
  • oxidized pyrimidine base lesion DNA N-glycosylase activity
    		•  1.2016453685638 bayes_pls_golite062009
  • binding
    		•  1.15752946565805 bayes_pls_golite062009
  • 5-formyluracil DNA N-glycosylase activity
    		•  1.08382823865081 bayes_pls_golite062009
  • 5-hydroxymethyluracil DNA N-glycosylase activity
    		•  1.08382823865081 bayes_pls_golite062009
  • DNA-3-methyladenine glycosylase I activity
    		•  1.06383943982125 bayes_pls_golite062009
  • uracil DNA N-glycosylase activity
    		•  0.879508131574476 bayes_pls_golite062009
  • purine-specific mismatch base pair DNA N-glycosylase activity
    		•  0.68578837518217 bayes_pls_golite062009
  • mismatch base pair DNA N-glycosylase activity
    		•  0.661651574677137 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.493252955870142 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.32094102946624 bayes_pls_golite062009
  • protein binding
    		•  0.0921713980805489 bayes_pls_golite062009
  • carbon-oxygen lyase activity
    		•  0.0676784802238829 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0420287478494503 bayes_pls_golite062009
    2
    Term Confidence Notes
  • hydrolase activity
    		•  1.97832429767892 bayes_pls_golite062009
  • MutLbeta complex binding
    		•  1.6622730780365 bayes_pls_golite062009
  • MutSbeta complex binding
    		•  1.6622730780365 bayes_pls_golite062009
  • catalytic activity
    		•  1.49075808737475 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.17432828048794 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.17362790812328 bayes_pls_golite062009
  • binding
    		•  0.804982034963737 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.654571025500586 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.546676461152337 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle