YRC Public Data Repository - Protein Structure Prediction

Protein:	nth1
Organism:	Schizosaccharomyces pombe
Length:	355 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nth1.

Description	E-value	Query Range	Subject Range
gi\|75819192, gi\|... - gi\|75819192\|ref\|ZP_00749285.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae V51], gi\|11621...	267.0	[0..24]	[351..22]
gi\|24349580, gi\|... - gi\|24374879\|ref\|NP_718922.1\| A/G-specific adenine glycosylase [Shewanella oneidensis MR-1], gi\|24349... SO3368 - A/G-specific adenine glycosylase	264.0	[0..25]	[351..10]
gi\|116189574, gi... - gi\|75829107\|ref\|ZP_00758424.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae MO10], gi\|1161...	264.0	[0..24]	[351..22]
gi\|75822032, gi\|... - gi\|75822032\|ref\|ZP_00751746.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae RC385], gi\|116...	264.0	[0..24]	[351..22]
gi\|227008550, gi... - gi\|227080662\|ref\|YP_002809213.1\| A/G-specific adenine glycosylase [Vibrio cholerae M66-2], gi\|227008... gi\|121728580, gi... - gi\|121728580\|ref\|ZP_01681601.1\| A/G-specific adenine glycosylase [Vibrio cholerae V52], gi\|121629136... gi\|15640479, gi\|... - gi\|9654877\|gb\|AAF93625.1\| A/G-specific adenine glycosylase [Vibrio cholerae O1 biovar El Tor str. N1... gi\|11354352 - pir\|\|D82320 A/G-specific adenine glycosylase VC0452 [imported] - Vibrio cholerae (strain N16961 sero... gi\|125618186 - gi\|125618186\|gb\|EAZ46730.1\| A/G-specific adenine glycosylase [Vibrio cholerae MO10] gi\|153224226, gi... - gi\|153224226\|ref\|ZP_01954309.1\| A/G-specific adenine glycosylase [Vibrio cholerae MAK 757], gi\|12411... gi\|153823186, gi... - gi\|153823186\|ref\|ZP_01975853.1\| A/G-specific adenine glycosylase [Vibrio cholerae B33], gi\|126519312... gi\|153819148, gi... - gi\|153819148\|ref\|ZP_01971815.1\| A/G-specific adenine glycosylase [Vibrio cholerae NCTC 8457], gi\|126...	261.0	[0..24]	[351..6]
gi\|78504971, gi\|... - gi\|78687322\|ref\|ZP_00852074.1\| A/G-specific adenine glycosylase MutY [Shewanella sp. ANA-3], gi\|7850...	261.0	[0..25]	[351..10]
gi\|113888199, gi... - gi\|114046757\|ref\|YP_737307.1\| A/G-specific DNA-adenine glycosylase [Shewanella sp. MR-7], gi\|1138881...	260.0	[0..25]	[351..10]
gi\|75825853 - gi\|75825853\|ref\|ZP_00755288.1\| COG1194: A/G-specific DNA glycosylase [Vibrio cholerae O395]	260.0	[0..24]	[351..22]
gi\|82404408, gi\|... - gi\|82497582\|ref\|ZP_00883114.1\| A/G-specific adenine glycosylase MutY [Shewanella sp. MR-4], gi\|82404...	259.0	[0..25]	[351..10]
gi\|91073918, gi\|... - gi\|91212344\|ref\|YP_542330.1\| adenine DNA glycosylase [Escherichia coli UTI89], gi\|91073918\|gb\|ABE087... gi\|226899425, gi... - gi\|237706385\|ref\|ZP_04536866.1\| adenine DNA glycosylase [Escherichia sp. 3_2_53FAA], gi\|226899425\|gb...	255.0	[0..8]	[327..2]

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Predicted Domain #1

Region A:
Residues: [1-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKDYGTPPE NWREVYDEIC KMKAKVVAPV DVQGCHTLGE RNDPKKFRFQ TLVALMLSSQ  60
   61 TKDIVLGPTM RNLKEKLAGG LCLEDIQNID EVSLNKLIEK VGFHNRKTIY LKQMARILSE 120
  121 KFQGDIPDTV EDLMTLPGVG PKMGYLCMSI AWNKTVGIGV DVHVHRICNL LHWCNTKTEE 180
  181 QTRAALQSWL PKELWFELNH TLVGFGQTIC LPRGRRC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	56.221849
Match:	2abkA
Description:	REFINEMENT OF THE NATIVE STRUCTURE OF ENDONUCLEASE III TO A RESOLUTION OF 1.85 ANGSTROM
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA N-glycosylase activity	4.8124964619976	bayes_pls_golite062009
hydrolase activity, hydrolyzing N-glycosyl compounds	4.26870112679392	bayes_pls_golite062009
DNA-(apurinic or apyrimidinic site) lyase activity	3.71152530486175	bayes_pls_golite062009
oxidized base lesion DNA N-glycosylase activity	2.49872706126491	bayes_pls_golite062009
hydrolase activity	2.39042189031819	bayes_pls_golite062009
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity	2.21048599823382	bayes_pls_golite062009
hydrolase activity, acting on glycosyl bonds	2.18053745735048	bayes_pls_golite062009
catalytic activity	2.13345932727422	bayes_pls_golite062009
alkylbase DNA N-glycosylase activity	1.5832578018127	bayes_pls_golite062009
DNA binding	1.44394874535958	bayes_pls_golite062009
nucleic acid binding	1.36800347239439	bayes_pls_golite062009
oxidized purine base lesion DNA N-glycosylase activity	1.32985950765371	bayes_pls_golite062009
damaged DNA binding	1.32391480975295	bayes_pls_golite062009
oxidized pyrimidine base lesion DNA N-glycosylase activity	1.2016453685638	bayes_pls_golite062009
binding	1.15752946565805	bayes_pls_golite062009
5-formyluracil DNA N-glycosylase activity	1.08382823865081	bayes_pls_golite062009
5-hydroxymethyluracil DNA N-glycosylase activity	1.08382823865081	bayes_pls_golite062009
DNA-3-methyladenine glycosylase I activity	1.06383943982125	bayes_pls_golite062009
uracil DNA N-glycosylase activity	0.879508131574476	bayes_pls_golite062009
purine-specific mismatch base pair DNA N-glycosylase activity	0.68578837518217	bayes_pls_golite062009
mismatch base pair DNA N-glycosylase activity	0.661651574677137	bayes_pls_golite062009
transcription regulator activity	0.493252955870142	bayes_pls_golite062009
structure-specific DNA binding	0.32094102946624	bayes_pls_golite062009
protein binding	0.0921713980805489	bayes_pls_golite062009
carbon-oxygen lyase activity	0.0676784802238829	bayes_pls_golite062009
double-stranded DNA binding	0.0420287478494503	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [218-355]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DMCTLSSKGL CPSAFKEKSG ITITKRKVKT IKRVKKRPAS ESPPLSPLSL PTDDLYYQSI  60
   61 EDKSLIKLED LDPVDSISHM NEPLKKEPAA DIDVDQKPPV AFHSTTKETR SLRRSKRVAK 120
  121 KSSQYFSQQS LQDIEDLV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	6.69897
Match:	1x51A
Description:	Solution structure of the NUDIX domain from human A/G-specific adenine DNA glycosylase alpha-3 splice isoform
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	1.97832429767892	bayes_pls_golite062009
MutLbeta complex binding	1.6622730780365	bayes_pls_golite062009
MutSbeta complex binding	1.6622730780365	bayes_pls_golite062009
catalytic activity	1.49075808737475	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	1.17432828048794	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	1.17362790812328	bayes_pls_golite062009
binding	0.804982034963737	bayes_pls_golite062009
nucleic acid binding	0.654571025500586	bayes_pls_golite062009
pyrophosphatase activity	0.546676461152337	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: