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Protein Overview: csn4

General Information:
Name(s) found: csn4 / SPAC22A12.03c [Sanger Pombe]
Description(s) found:
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  • gi|7490940|pir||T38143 hypothetical protein SPAC22A12.03c - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|30913001|sp|O13895.1|CSN4_SCHPO RecName: Full=COP9 signalosome complex subunit 4; Short=SGN4; Short=CSN complex subunit 4 [NCBI NR]
  • gi|2414596|emb|CAB16573.1| COP9/signalosome complex subunit Csn4 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19114145|ref|NP_593233.1| COP9/signalosome complex subunit Csn4 [Schizosaccharomyces pombe] [NCBI NR]
  • COP9/signalosome complex subunit Csn4 [Sanger Pombe]
  • COP9 signalosome complex subunit 4 OS=Schizosaccharomyces pombe GN=csn4 PE=1 SV=1 [Swiss-Prot]
  • COP9/SIGNALOSOME COMPLEX SUBUNIT 4; PCI DOMAIN; NO APPARENT S. CEREVISIAE ORTHOLOG: O13895; [pompepVF.fasta]
  • COP9/SIGNALOSOME COMPLEX SUBUNIT 4; PCI DOMAIN: O13895; [pompepV13]
  • COP9 signalosome complex subunit 4 (CSN complex subunit 4) (SGN4) [pompep4896]
  • |csn4||COP9/signalosome complex subunit 4 (PMID 11854407) [pompepnew.fasta]
  • |csn4||COP9/signalosome complex (subunit 4) (PMID 11854407)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • COP9/signalosome complex subunit 4; PCI domain [Schizosaccharomyces pombe]gi|2414596|emb|CAB16573.1| SPAC22A12.03c [Schizosaccharomyces pombe]gi|30913001|sp|O13895|CSN4_SCHPO COP9 signalosome complex subunit 4 (CSN complex subunit 4) (SGN4)gi|7490940|p [nrdb_11152004_Chlamydomonas]
  • |csn4||COP9/signalosome complex |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (O13895) COP9 signalosome complex subunit 4 (CSN complex subunit 4) (SGN4) [pompep4896_normal_reversed]
  • |csn4||COP9/signalosome complex subunit Csn4|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC22A12.03c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC22A12.03c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • COP9 signalosome complex subunit 4 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=csn4 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    signalosome [NAS]
    Biological Process: regulation of proteasomal ubiquitin-dependent protein catabolic process [NAS]
    cell cycle [RCALink to PubMed article]
    cullin deneddylation [NAS]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEVVHYFLE GNMPVAQFRE ALALHYTNEK ELFEQAKRCL NICCGSNNFA KRNDVLFSLL  60
   61 DVAVSISSLE LRKELISELY VPVQSLEEAP SEYLVSCCLQ LATIYEAEQN FELLCSSLEA 120
  121 VEKHGHFEND LEQLLLLRIR LGDAYLKLGK AEKAILTVRT SIPLAFKVSN DQLLMELQLC 180
  181 NARALDETGQ FLEAAKCYYR VLQYKVPGNE LIYRENLCSV AQCLLLAIPS PIVLQFLQEI 240
  241 SLQPSVREIP FYSLVEKYLK RKFIGKEDGA FLLPFLLPHQ VIHMNRLIED GRHFLETNIL 300
  301 FLSEFFEVSS TSILAKHFKL SEEQVDTVVA DMVIQERLNA SIDQCEGYIT FLPEYGKANN 360
  361 LPNYVNKIAT VLQHYGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] FFAS03 1.33 Vesicular transport protein sec17
    2 View Details [285..377] PSI-BLAST 15.69897 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.64850159998065 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.60682647486188 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.57767877959184 bayes_pls_golite062009
  • protein binding
    		•  1.51322932625387 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.48377790267007 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.38123254005315 bayes_pls_golite062009
  • DNA binding
    		•  1.32823848889363 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.944333231961432 bayes_pls_golite062009
  • transcription factor activity
    		•  0.679223944174373 bayes_pls_golite062009
  • hydrolase activity
    		•  0.63851966218836 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.563836491184155 bayes_pls_golite062009
  • transcription factor binding
    		•  0.202402797164729 bayes_pls_golite062009
  • transferase activity
    		•  0.157308242400253 bayes_pls_golite062009
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.76121492612224 bayes_pls_golite062009
  • DNA binding
    		•  4.45042383195146 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.3254009446371 bayes_pls_golite062009
  • transcription factor activity
    		•  3.7855017556511 bayes_pls_golite062009
  • binding
    		•  3.52874320222492 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.23304004014963 bayes_pls_golite062009
  • transcription activator activity
    		•  2.05043065144612 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.93737634607471 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.27763700765562 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.23862224095769 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.12147035668008 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.754042916649094 bayes_pls_golite062009
  • protein binding
    		•  0.753698599635855 bayes_pls_golite062009
  • transcription factor binding
    		•  0.612315945412079 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.486434906547244 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.249771970501337 bayes_pls_golite062009
  • hydrolase activity
    		•  0.140191206949582 bayes_pls_golite062009
  • transferase activity
    		•  0.064832527337659 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle