YRC Public Data Repository - Protein Structure Prediction

Protein:	csn4
Organism:	Schizosaccharomyces pombe
Length:	377 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for csn4.

Description	E-value	Query Range	Subject Range
gi\|42415501, gi\|... - gi\|42415501\|ref\|NP_963872.1\| proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 [Danio reri...	297.0	[0..16]	[372..77]
gi\|73965261 - gi\|73965261\|ref\|XP_862191.1\| PREDICTED: similar to proteasome 26S non-ATPase subunit 12 isoform 2 is...	295.0	[0..16]	[372..57]
ENSMMUG000000021... - null, null ENSPTRT00000045693 - null gi\|119609434, gi... - gi\|28872765\|ref\|NP_777360.1\| proteasome 26S non-ATPase subunit 12 isoform 2 [Homo sapiens], gi\|19378...	294.0	[0..16]	[372..57]
PSD12_PONAB - 26S proteasome non-ATPase regulatory subunit 12 OS=Pongo abelii GN=PSMD12 PE=2 SV=3 PSD12_PONPY - 26S proteasome non-ATPase regulatory subunit 12 - Pongo pygmaeus (Orangutan)	293.0	[0..16]	[372..77]
gi\|53136554, gi\|... - gi\|71897101\|ref\|NP_001025877.1\| proteasome 26S non-ATPase subunit 12 [Gallus gallus], gi\|53136554\|em...	292.0	[0..16]	[372..77]
gi\|54400716, gi\|... - gi\|54400716\|ref\|NP_001005875.1\| proteasome 26S non-ATPase subunit 12 [Rattus norvegicus], gi\|5373354...	292.0	[0..16]	[372..77]
PSD12_BOVIN - 26S proteasome non-ATPase regulatory subunit 12 OS=Bos taurus GN=PSMD12 PE=2 SV=3	291.0	[0..16]	[372..77]
PSD12_MOUSE - 26S proteasome non-ATPase regulatory subunit 12 OS=Mus musculus GN=Psmd12 PE=1 SV=4	291.0	[0..16]	[372..77]

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Predicted Domain #1

Region A:
Residues: [1-284]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEEVVHYFLE GNMPVAQFRE ALALHYTNEK ELFEQAKRCL NICCGSNNFA KRNDVLFSLL  60
   61 DVAVSISSLE LRKELISELY VPVQSLEEAP SEYLVSCCLQ LATIYEAEQN FELLCSSLEA 120
  121 VEKHGHFEND LEQLLLLRIR LGDAYLKLGK AEKAILTVRT SIPLAFKVSN DQLLMELQLC 180
  181 NARALDETGQ FLEAAKCYYR VLQYKVPGNE LIYRENLCSV AQCLLLAIPS PIVLQFLQEI 240
  241 SLQPSVREIP FYSLVEKYLK RKFIGKEDGA FLLPFLLPHQ VIHM

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.33
Match:	1qqeA
Description:	Vesicular transport protein sec17
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	2.64850159998065	bayes_pls_golite062009
small conjugating protein ligase activity	1.60682647486188	bayes_pls_golite062009
transcription regulator activity	1.57767877959184	bayes_pls_golite062009
protein binding	1.51322932625387	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.48377790267007	bayes_pls_golite062009
nucleic acid binding	1.38123254005315	bayes_pls_golite062009
DNA binding	1.32823848889363	bayes_pls_golite062009
acid-amino acid ligase activity	0.944333231961432	bayes_pls_golite062009
transcription factor activity	0.679223944174373	bayes_pls_golite062009
hydrolase activity	0.63851966218836	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.563836491184155	bayes_pls_golite062009
transcription factor binding	0.202402797164729	bayes_pls_golite062009
transferase activity	0.157308242400253	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [285-377]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NRLIEDGRHF LETNILFLSE FFEVSSTSIL AKHFKLSEEQ VDTVVADMVI QERLNASIDQ  60
   61 CEGYITFLPE YGKANNLPNY VNKIATVLQH YGS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	15.69897
Match:	1ufmA
Description:	Solution structure of the PCI domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	4.76121492612224	bayes_pls_golite062009
DNA binding	4.45042383195146	bayes_pls_golite062009
nucleic acid binding	4.3254009446371	bayes_pls_golite062009
transcription factor activity	3.7855017556511	bayes_pls_golite062009
binding	3.52874320222492	bayes_pls_golite062009
sequence-specific DNA binding	2.23304004014963	bayes_pls_golite062009
transcription activator activity	2.05043065144612	bayes_pls_golite062009
transcription repressor activity	1.93737634607471	bayes_pls_golite062009
small conjugating protein ligase activity	1.27763700765562	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.23862224095769	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.12147035668008	bayes_pls_golite062009
acid-amino acid ligase activity	0.754042916649094	bayes_pls_golite062009
protein binding	0.753698599635855	bayes_pls_golite062009
transcription factor binding	0.612315945412079	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	0.486434906547244	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.249771970501337	bayes_pls_golite062009
hydrolase activity	0.140191206949582	bayes_pls_golite062009
transferase activity	0.064832527337659	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: