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Protein Overview: cdt1

General Information:
Name(s) found: cdt1 / SPBC428.18 [Sanger Pombe]
Description(s) found:
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  • gi|3947882|emb|CAA22293.1| replication licensing factor Cdt1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19859317|sp|P40382.2|CDT1_SCHPO RecName: Full=Cell division cycle protein cdt1 [NCBI NR]
  • gi|19111988|ref|NP_595196.1| replication licensing factor Cdt1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • replication licensing factor Cdt1 [Sanger Pombe]
  • Cell division cycle protein cdt1 OS=Schizosaccharomyces pombe GN=cdt1 PE=2 SV=2 [Swiss-Prot]
  • REPLICATION INITIATION FACTOR; CELL DIVISION CYCLE PROTEIN; ESSENTIAL; TARGET OF THE CDC10/SCT1 TF; REQUIRED FOR DNA SYNTHESIS; REQUIRED FOR THE INHIBITION OF MITOSIS; NO APPARENT S. CEREVISIAE ORTHOLOG: P40382;Q9URL6; [pompepVF.fasta]
  • REPLICATION INITIATION FACTOR; CELL DIVISION CYCLE PROTEIN CDT1: P40382;Q9URL6; [pompepV13]
  • Cell division cycle protein cdt1 [pompep4896]
  • |cdt1||replication initiation factor [pompepnew.fasta]
  • |cdt1||involved in DNA replication (initiation) (required)|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • |cdt1||replication licensing factor cdt1|Schizosaccharomyces pombe|chr 2|||Manual [pompep2242005.fasta]
  • cell division cycle protein cdt1; replication factor [Schizosaccharomyces pombe]gi|3947882|emb|CAA22293.1| involved in DNA replication (initiation) (required); regulated by DSC1/MBF complex; essential (PMID 8313888); involved in DNA replication (required [nrdb_11152004_Chlamydomonas]
  • (P40382) Cell division cycle protein cdt1 [pompep4896_normal_reversed]
  • |cdt1||replication licensing factor Cdt1|Schizosaccharomyces pombe|chr 2|||Manual [pombe030305.revfasta]
  • SPBC428.18 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPBC428.18 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Cell division cycle protein cdt1 OS=Schizosaccharomyces pombe GN=cdt1 PE=1 SV=2 [UniProt_SPombe_10-04-2010_reversed.fasta]
  • Cell division cycle protein cdt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdt1 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: pre-replicative complex [ISSLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: DNA replication initiation [IDALink to PubMed article]
    DNA replication checkpoint [TASLink to PubMed article]
    regulation of DNA replication initiation [IMPLink to PubMed article]
    pre-replicative complex assembly [TASLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKCRALYSHD NNILIFGFCV QIMSAGSQTK LNFSVRKTRS SSKRSNAAII EPPKNPEDSQ  60
   61 IIPAVKRLKE NLDTESLEQN EVLPPVKNES VLFLEKVFNA VDICVKFHLS INTKPTFVLL 120
  121 ENKVSGLTKI SLKITHLAQI LTVWPESFAI TPCFTIHQGK RVATYELSYP RNANLPEAFS 180
  181 RSIEFKRRLE KWLLEHCSET EIPAQQLQAL PSLSKNTVNE SSLVRKLNLE KSTSRELRIP 240
  241 TQTLEPKFTT NTAKYANELV SCSMLDSSST LSKSVNSKIN LKSHQSSSSV QNSSRKLTSS 300
  301 QLTLRQSSLF DRVRKKQKAM EAKKAEEFKN NLVVHTLAKE KVSFVRIIDL IFVQLSTWPT 360
  361 KRSFSMSEIV TSMQMSISSS LSPDQCAKAI ELLSKALPAW CTINLLGNIQ VVTFSRIVNG 420
  421 KPYLRSQLIE ELQTKASITI LSNS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..284] FFAS03 5.12 Strucure of Geminin-Cdt1 complex
    2 View Details [285..444] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.98098149944065 bayes_pls_golite062009
  • DNA binding
    		•  4.60314587965928 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.41560500044233 bayes_pls_golite062009
  • transcription factor activity
    		•  3.83751005834021 bayes_pls_golite062009
  • transcription repressor activity
    		•  3.4177129498808 bayes_pls_golite062009
  • binding
    		•  3.37660003833383 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.84400558797599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.21432668306508 bayes_pls_golite062009
  • transcription activator activity
    		•  2.05647866476552 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.28362954833504 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.815066484495067 bayes_pls_golite062009
  • transcription factor binding
    		•  0.732240481554495 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.532564808675204 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.437617796040738 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.125572630057905 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.47

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle