Protein Overview: cdc18

General Information:
Name(s) found:	cdc18 / SPBC14C8.07c [Sanger Pombe]
Description(s) found: SHOW ONLY BEST	pir\|\|A40726 cell division control protein CDC18+ - fission yeast (Schizosaccharomyces pombe) [NCBI NR] gi\|311174\|gb\|AAA02871.1\| cell division cycle protein [Schizosaccharomyces pombe] [NCBI NR] gi\|3006165\|emb\|CAA18425.1\| MCM loader [Schizosaccharomyces pombe] [NCBI NR] gi\|19112702\|ref\|NP_595910.1\| MCM loader [Schizosaccharomyces pombe] [NCBI NR] gi\|1168808\|sp\|P41411.1\|CDC18_SCHPO RecName: Full=Cell division control protein 18 [NCBI NR] MCM loader [Sanger Pombe] Cell division control protein 18 OS=Schizosaccharomyces pombe GN=cdc18 PE=1 SV=1 [Swiss-Prot] (P41411) Cell division control protein 18 [Swiss-Prot] REPLICATION INITIATION FACTOR; MCM LOADER; CELL DIVISION CONTROL COUPLES CELL CYCLE SIGNALS TO DNA REPLICATION MACHINERY; SIMILAR TO S. CEREVISIAE CDC6: P41411; [pompepVF.fasta] REPLICATION INITIATION FACTOR; CELL DIVISION CONTROL PROTEIN THAT COUPLES CELL CYCLE SIGNALS TO DNA REPLICATION MACHINERY: P41411; [pompepV13] Cell division control protein 18 [pompep4896] \|cdc18\|\|replication initiation factor [pompepnew.fasta] \|cdc18\|\|involved in DNA replication (initiation)\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pombe041504.fasta] \|cdc18\|\|MCM loader\|Schizosaccharomyces pombe\|chr 2\|\|\|Manual [pompep2242005.fasta] cell division control protein 18 [Schizosaccharomyces pombe]gi\|3006165\|emb\|CAA18425.1\| cdc18 [Schizosaccharomyces pombe]gi\|539072\|pir\|\|A40726 cell division control protein CDC18+ - fission yeast (Schizosaccharomyces pombe)gi\|1168808\|sp\|P41411\|CC18_SCH [nrdb_11152004_Chlamydomonas] hypothetical protein SPBC14C8.07c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta] SPBC14C8.07c [Schizosaccharomyces pombe] [nr-271106-contam.fasta] cell division cycle protein [nr-271106-contam.fasta] Cell division control protein 18 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cdc18 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
Organism:	Schizosaccharomyces pombe
Length:	577 amino acids
Gene Ontology:
Cellular Component:	pre-replicative complex [ISS] nuclear replication fork [IC]
Biological Process:	DNA replication initiation [IMP] DNA replication checkpoint [IMP] M phase of mitotic cell cycle [RCA] pre-replicative complex assembly [ISS]
Molecular Function:	ATP binding [ISS] DNA clamp loader activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCETPIGCHT PRRCNRFIDS AALIDCTNKT NQREHSPSFS IEIPTTPSRK RTLASSHFQT  60
   61 PTKRIKYELG ELQEEKTDLY PNFPAQLKEN KKPKLPTTPQ TPKTPKRTIQ IVTPKSLNRT 120
  121 CNPVPFATRL LQSTPHRQLF PPTPSTPSTP SYNSTAKLSL RKSYRSAGVV GRENEKSIVE 180
  181 SFFRQHLDAN AGGALYVSGA PGTGKTVLLH NVLDHVVSDY PKVNVCYINC MTINEPKAIF 240
  241 EKIHSKIVKE EILENEDHHI NFQCELESHF TQSANELYNP VIIVLDEMDH LIAREQQVLY 300
  301 TLFEWPSRPT SRLILVGIAN ALDMTDRFLP RLRTKHITPK LLSFTPYTAQ EISTIIKARL 360
  361 KTAATTSEKN NPFTPIKSIS EVSDDSINVV SQHADETPFI HPAAIELCAR KVAASSGDLR 420
  421 KALDICRHAI ELAEREWKAQ HDNTLSSVDI PRASIAHVVR ATSAMSQSAS ARLKNLGLQQ 480
  481 KAILCTLVVC EKTSLSVADV FEKYSSLCLR DRLIYPLTSS EFCDVANSLE TLAIIRLRTK 540
  541 QRNGKPQDRI ISLLVPEMDV ITAVGDIGTL KRFFDRR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
DNA clamp loader activity	4.91429252297969	bayes_pls_golite062009
protein-DNA loading ATPase activity	4.80695929076807	bayes_pls_golite062009
DNA-directed DNA polymerase activity	3.93573252384865	bayes_pls_golite062009
DNA-dependent ATPase activity	2.72462789867829	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	2.66107861968804	bayes_pls_golite062009
binding	2.64537357529343	bayes_pls_golite062009
nucleic acid binding	2.51683451033161	bayes_pls_golite062009
DNA helicase activity	2.2817164193758	bayes_pls_golite062009
DNA binding	2.12258000781149	bayes_pls_golite062009
transcription regulator activity	2.09345198747025	bayes_pls_golite062009
pyrophosphatase activity	2.04806869603661	bayes_pls_golite062009
ATP-dependent DNA helicase activity	1.88455339138556	bayes_pls_golite062009
helicase activity	1.70242731830224	bayes_pls_golite062009
DNA replication origin binding	1.62491387774159	bayes_pls_golite062009
microtubule motor activity	1.35938517416356	bayes_pls_golite062009
ATP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
purine NTP-dependent helicase activity	1.19311444180077	bayes_pls_golite062009
motor activity	1.14667913749579	bayes_pls_golite062009
histone acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
lysine N-acetyltransferase activity	1.05990253628867	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
transcription factor activity	0.887108427603557	bayes_pls_golite062009
transcription repressor activity	0.862685397469217	bayes_pls_golite062009
DNA polymerase activity	0.795745617990735	bayes_pls_golite062009
structure-specific DNA binding	0.782430219754236	bayes_pls_golite062009
double-stranded DNA binding	0.6071273686445	bayes_pls_golite062009
cytoskeletal protein binding	0.500462538667228	bayes_pls_golite062009
nucleotidyltransferase activity	0.367559137329714	bayes_pls_golite062009
RNA helicase activity	0.18426050934025	bayes_pls_golite062009
protein binding	0.170837278876362	bayes_pls_golite062009
RNA-dependent ATPase activity	0.14606996093053	bayes_pls_golite062009
ATP-dependent RNA helicase activity	0.13050483816765	bayes_pls_golite062009
nucleotide binding	0.114848452385726	bayes_pls_golite062009
purine nucleotide binding	0.10713474095071	bayes_pls_golite062009
purine ribonucleotide binding	0.0916519414118148	bayes_pls_golite062009
ribonucleotide binding	0.0915913646217636	bayes_pls_golite062009
structural constituent of ribosome	0.089234257580272	bayes_pls_golite062009
3'-5' DNA helicase activity	0.0769112340058804	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0530667986761242	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.028470639373934	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0265151533232588	bayes_pls_golite062009
actin binding	0.00482938540552702	bayes_pls_golite062009

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..144]	MSA	2.727994	View MSA. No confident structure predictions are available.
2	View Details	[145..577]	PSI-BLAST	59.69897	EDTA treated

Protein Overview: cdc18

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: