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Protein Overview: cdc18

General Information:
Name(s) found: cdc18 / SPBC14C8.07c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • MCM loader [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 577 amino acids

    Gene Ontology:
    Cellular Component: pre-replicative complex [ISSLink to PubMed article]
    nuclear replication fork [ICLink to PubMed article]
    Biological Process: DNA replication initiation [IMPLink to PubMed article]
    DNA replication checkpoint [IMPLink to PubMed article]
    M phase of mitotic cell cycle [RCALink to PubMed article]
    pre-replicative complex assembly [ISSLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    DNA clamp loader activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCETPIGCHT PRRCNRFIDS AALIDCTNKT NQREHSPSFS IEIPTTPSRK RTLASSHFQT  60
   61 PTKRIKYELG ELQEEKTDLY PNFPAQLKEN KKPKLPTTPQ TPKTPKRTIQ IVTPKSLNRT 120
  121 CNPVPFATRL LQSTPHRQLF PPTPSTPSTP SYNSTAKLSL RKSYRSAGVV GRENEKSIVE 180
  181 SFFRQHLDAN AGGALYVSGA PGTGKTVLLH NVLDHVVSDY PKVNVCYINC MTINEPKAIF 240
  241 EKIHSKIVKE EILENEDHHI NFQCELESHF TQSANELYNP VIIVLDEMDH LIAREQQVLY 300
  301 TLFEWPSRPT SRLILVGIAN ALDMTDRFLP RLRTKHITPK LLSFTPYTAQ EISTIIKARL 360
  361 KTAATTSEKN NPFTPIKSIS EVSDDSINVV SQHADETPFI HPAAIELCAR KVAASSGDLR 420
  421 KALDICRHAI ELAEREWKAQ HDNTLSSVDI PRASIAHVVR ATSAMSQSAS ARLKNLGLQQ 480
  481 KAILCTLVVC EKTSLSVADV FEKYSSLCLR DRLIYPLTSS EFCDVANSLE TLAIIRLRTK 540
  541 QRNGKPQDRI ISLLVPEMDV ITAVGDIGTL KRFFDRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..144] MSA 2.727994 View MSA. No confident structure predictions are available.
    2 View Details [145..577] PSI-BLAST 59.69897 EDTA treated

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • DNA clamp loader activity
    		•  4.91429252297969 bayes_pls_golite062009
  • protein-DNA loading ATPase activity
    		•  4.80695929076807 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  3.93573252384865 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  2.72462789867829 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.66107861968804 bayes_pls_golite062009
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • DNA helicase activity
    		•  2.2817164193758 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.04806869603661 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  1.88455339138556 bayes_pls_golite062009
  • helicase activity
    		•  1.70242731830224 bayes_pls_golite062009
  • DNA replication origin binding
    		•  1.62491387774159 bayes_pls_golite062009
  • microtubule motor activity
    		•  1.35938517416356 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  1.19311444180077 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.05990253628867 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.862685397469217 bayes_pls_golite062009
  • DNA polymerase activity
    		•  0.795745617990735 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.782430219754236 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.6071273686445 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  0.367559137329714 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.18426050934025 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.14606996093053 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.13050483816765 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • 3'-5' DNA helicase activity
    		•  0.0769112340058804 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0530667986761242 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.028470639373934 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0265151533232588 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle