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Protein Overview: alp13

General Information:
Name(s) found: alp13 / SPAC23H4.12 [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • Clr6 histone deacetylase complex subunit Alp13 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 337 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    NuA4 histone acetyltransferase complex [IDALink to PubMed article]
    nuclear chromatin [ICLink to PubMed article]
    Rpd3S complex [IDALink to PubMed articleLink to PubMed article]
    Biological Process: chromatin remodeling [ICLink to PubMed article]
    chromosome condensation [IMPLink to PubMed article]
    establishment or maintenance of cell polarity [IMPLink to PubMed article]
    chromatin assembly or disassembly [IEA]
    histone acetylation [IC]
    histone deacetylation [IGILink to PubMed article][IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    chromatin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSYKVNER VLCFHGPLLY EAKIVDTEMK GDVTTYLIHY KGWKNSWDEW VEQDRILQWT  60
   61 EENLKTQKEL KNAAISTRQK PTSKKSASST SKHDSTGVKT SGKRSRESST VTVDGDSHEL 120
  121 PSRIKTQKSE SPIPQQVKRD GTTDAKNEET TKPENNEKDD FEEEPPLPKH KISVPDVLKL 180
  181 WLVDDWENIT KNQQLIAIPR NPTVRAAIAA FRESKISHLN NEIDVDVFEQ AMAGLVIYFN 240
  241 KCLGNMLLYR FERQQYLEIR QQYPDTEMCD LYGVEHLIRL FVSLPELIDR TNMDSQSIEC 300
  301 LLNYIEEFLK YLVLHKDEYF IKEYQNAPPN YRSLVGV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..75] PSI-BLAST 23.0 No description for 2efiA was found.
    2 View Details [76..165] deduced N/A No confident structure predictions are available.
    3 View Details [166..337] PSI-BLAST 58.69897 Crystal Structure of the MRG15 MRG domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • chromatin binding
    		•  3.84065302930105 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • satellite DNA binding
    		•  1.4681464542396 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle