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Protein Overview: Tak1-PA

General Information:
Name(s) found: Tak1-PA / FBpp0077011 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene TGF-Ã?&#142;Ã?² activated kinase 1 is referred to in FlyBase by the symbol Dmel\Tak1 (CG18492, FBgn0026323). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:20386932..20395953. It has the cytological map location 19D2. There is experimental evidence that it has the molecular function</span>: JUN kinase kinase kinase activity. There is experimental evidence that it is involved in the biological process</span>: immune response; notum morphogenesis; apoptosis; dorsal closure; compound eye development; activation of JNKK activity; JNK cascade; ommatidial rotation; I-kappaB kinase/NF-kappaB cascade. 25 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: external compound sense organ; peripheral nervous system; organ system; nervous system; compound cell cluster organ; cuticle; cuticular specialization; imaginal precursor; cephalopharyngeal skeleton; proteinaceous extracellular matrix; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 678 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: dorsal closure [IMP][TAS]
    ommatidial rotation [IMP]
    signal transduction [NAS]
    activation of JNKK activity [IMP]
    JNK cascade [IGI][TAS]
    protein amino acid phosphorylation [NAS]
    defense response [NAS]
    I-kappaB kinase/NF-kappaB cascade [IMP]
    positive regulation of antibacterial peptide biosynthetic process [TAS]
    compound eye development [IMP]
    notum morphogenesis [IMP]
    immune response [IMP][TAS]
    innate immune response [TAS]
    apoptosis [IGI][IMP]
    Molecular Function: ATP binding [IEA]
    protein tyrosine kinase activity [IEA]
    JUN kinase kinase kinase activity [IMP]
    protein kinase activity [NAS]
    MAP kinase kinase kinase activity [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATASLDALQ AAYVDFSEIT LREKVGHGSY GVVCKAVWRD KLVAVKEFFA SAEQKDIEKE  60
   61 VKQLSRVKHP NIIALHGISS YQQATYLIME FAEGGSLHNF LHGKVKPAYS LAHAMSWARQ 120
  121 CAEGLAYLHA MTPKPLIHRD VKPLNLLLTN KGRNLKICDF GTVADKSTMM TNNRGSAAWM 180
  181 APEVFEGSKY TEKCDIFSWA IVLWEVLSRK QPFKGIDNAY TIQWKIYKGE RPPLLTTCPK 240
  241 RIEDLMTACW KTVPEDRPSM QYIVGVMHEI VKDYTGADKA LEYTFVNQQI VTKESDGTVA 300
  301 AQPDSLSSQE GELSPSSTQL TPTTAANANV NAIAISKTTT SSMTENTSST SSDITPTNSG 360
  361 QLDNNPLFYM VTNRWDAIPE EESNESRNDS FNLTSSAEAT QRLETIRNGM ILMACKPMEQ 420
  421 LTLDVEANGF DLSPSESSSS STNAKSDGRE RLTVTDTKPV MMTTDLSNNN GGIHAHSNGL 480
  481 LSHANGWQAR DEELQEQEHE QEIVNSLDVD VDPDEDENDG TEQSLAEILD PELQPEPPIP 540
  541 NDAESQLIYR DHRHMAKEYL SVDTNLYYAQ DFKDKLIVQM DRTEREQKQE LLRKMKDKEG 600
  601 LQSLYNNLQQ QYASRQLAAG HHPQPHPHPH PNQLQHPHSH PPMHFLQDEG CGLLPGSVCG 660
  661 GSESVEEGWV VIPPHHNA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..339] PSI-BLAST 66.522879 No description for 2evaA was found.
    2 View Details [340..478] deduced N/A No confident structure predictions are available.
    3 View Details [479..678] PSI-BLAST 13.69897 FAT domain of focal adhesion kinase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle