YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: pcm-PA

General Information:
Name(s) found: pcm-PA / FBpp0074553 [FlyBase]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • The gene pacman is referred to in FlyBase by the symbol Dmel\pcm (CG3291, FBgn0020261). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:19379913..19385984. It has the cytological map location 18C7. There is experimental evidence that it has the molecular function</span>: 5'-3' exoribonuclease activity. There is experimental evidence that it is involved in the biological process</span>: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; RNA interference; nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3'. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1612 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [NAS]
    cytoplasmic mRNA processing body [IDA]
    Biological Process: dorsal closure [IMP]
    wound healing [IMP]
    imaginal disc fusion, thorax closure [IMP]
    nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP]
    spermatogenesis [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    nuclear-transcribed mRNA catabolic process, exonucleolytic, 5'-3' [IMP]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    RNA interference [IMP]
    RNA catabolic process [NAS]
    gastrulation [NAS]
    Molecular Function: nucleic acid binding [IEA]
    5'-3' exoribonuclease activity [IDA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVPKFFRYI SERYPCLSEL AREHCIPEFD NLYLDMNGIV HNCSHPDDNN IHFHLEEEQI  60
   61 FQEIFNYVDK LFYLIKPQRL FFLSVDGVAP RAKMNQQRSR RFRTAREAEQ QEAKAAQRGE 120
  121 LREHERFDSN CITPGTEFMV RLQEGLRAFL KTKISTDPLW QRCTVILSGQ EAPGEGEHKI 180
  181 MDYIRYMKTQ PDYDPNTRHC LYGLDADLII LGLCTHELHF VVLREEVKFG RNVKRTSVEE 240
  241 TRFFLLHLGL LREYLELEFD ALRTDEHKLD IAQLIDDWVL MGFLVGNDFI PHLPCLHISS 300
  301 NALPLLYRTY IGIYPTLGGN INENGKLNLR RLQIFISALT EVELDHFKEH ADDLKYMNNK 360
  361 SEAFDMDVGE ITESQNLDSD LGALINKSML LYDDDSEEDC SDENAVLLKE FQNYKRNFYR 420
  421 NKFKRDPNDE LIEELCHHYV NALQWVLDYY YRGVQSWDWY YPFHYTPFIS DLKNIEQVEI 480
  481 AFHMGTPFLP FQQLLAVLPA ASAKLLPVAY HDLMLLPTSP LAEFYPLEFE SDLNGKKHDW 540
  541 EAVVLIPFID EGRLLAAMLP CEAQLSLEER ERNRHGPMYV YKYSTVAQGP MPAYPPLRAL 600
  601 PVLYCTEVAK WSHEIAVNLP YSVCIELPNA ARTVFFPGFP TMQHLPFDFE LRNDRVKVFE 660
  661 QVSRNQNIVL KPRKRQLEDT LTAVASQYLG KVIHVGWPHL VKAIVVRVAT RDQRVDSEGI 720
  721 TLNDSRRFDS ECKALQEHFI NRMGIQFANY DVLVYVRTFA GNSTEFRDKG ALMVRDSWSS 780
  781 SVTGYPAQGV VADLTVWERM RKNFLNVEHY FPVGSTIFLI TDPYYGSEGT VQDPRLAYTN 840
  841 GRIQVSIMVR PEPKVNAARQ LQEERDRDYL STFQVCNLLR ISGRTLGRLS GTVWVVLGPR 900
  901 RQKMENVTKH NIGLQLKYPR QNEERAGYCF RTNNQWYYSS LAVDLMRNYC QRYPDVIDFF 960
  961 GDSNDRAEFV FEQDVFPNAV GHRRVEELAN WVRQQPHMKV ERISCGSKTV CRETIELLIA1020
 1021 AVDDLRSLPV KHVKLQVKPH LLIKPNVTLP DVYRSKRPVR LFDRVVIVRT IYMVPVGTKG1080
 1081 TVIGIHPVTD PNPVRLECVH AVDTFCKVLF DSPVPNCNNI HGIAEDRVYK VPEIALVIIK1140
 1141 TDEEGKKQND CELPVRDPQP NQAQDEPVRA TSSRYVTAAG STSVPITMKT QISDEFVKTR1200
 1201 SDPIARTDSY KPSSEPKPVP VPEQITNWRE RVSTPTNKPQ PAPNNWRINR SSSRQQGGSI1260
 1261 FVAPPTKTPD AAASTASTAF TAASSATLTP LDQTLALMSV LGVGEDQSSP PLQEAVQQQR1320
 1321 PPLLQQQRAP FPGQMPNLPK PPLFWQQEAQ KQEALQQEAQ QQEAQKKQQQ AHAQMEPERI1380
 1381 NSQHFYRSGQ TGAALNQPPL GAPSKRQWHE WVHPRMQHAN AFHAGVNNGY QMRPKKNIAA1440
 1441 QSTFNNNVHM HLQQPYYPNQ QQQQQQQQPL QLTEINNAPP RYSTIQDFVP IQAYRPKKLN1500
 1501 RVQPAGRQDV DATKNPSRSP VLQQPTNETI DTKASSSLPV QSAGEQVIGL MQTLEIKPAA1560
 1561 SQSESDGVST GSANAPTATT SSQAVNRRKH RVPRIGAKFD LEYILPDSPH PT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..451] FFAS03 1.85 Crystal structure of the human FEN1-PCNA complex
    2 View Details [452..611] deduced N/A No confident structure predictions are available.
    3 View Details [612..836] deduced N/A No confident structure predictions are available.
    4 View Details [837..1011] deduced N/A No confident structure predictions are available.
    5 View Details [1012..1612] PSI-BLAST 8.39794 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endonuclease activity
    		•  2.45869331497094 bayes_pls_golite062009
  • hydrolase activity
    		•  2.24171130786956 bayes_pls_golite062009
  • binding
    		•  1.99360183638569 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.96755600188402 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.68917463278047 bayes_pls_golite062009
  • DNA binding
    		•  1.63116261448437 bayes_pls_golite062009
  • nuclease activity
    		•  1.55313849436792 bayes_pls_golite062009
  • exonuclease activity
    		•  1.29727662049967 bayes_pls_golite062009
  • catalytic activity
    		•  1.27951740231695 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  1.12391156671522 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.11025090301954 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.974421387546058 bayes_pls_golite062009
  • flap endonuclease activity
    		•  0.405877291452351 bayes_pls_golite062009
  • protein binding
    		•  0.388252010955945 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.371408632109349 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.237820137780736 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.234391225960316 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.097472492148219 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle