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Protein Overview: psh-PA

General Information:
Name(s) found: psh-PA / FBpp0074400 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • The gene persephone is referred to in FlyBase by the symbol Dmel\psh (CG6367, FBgn0030926). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:18378515..18380954. It has the cytological map location 17B5. There is experimental evidence that it has the molecular function</span>: peptidase activity. There is experimental evidence that it is involved in the biological process</span>: defense response to fungus; innate immune response; positive regulation of antifungal peptide biosynthetic process; proteolysis. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 394 amino acids

    Gene Ontology:
    Cellular Component: extracellular region [IDA]
    Biological Process: positive regulation of antifungal peptide biosynthetic process [IMP]
    innate immune response [IDA]
    proteolysis [IMP][NAS][TAS]
    regulation of Toll signaling pathway [TAS]
    defense response to fungus [IMP][TAS]
    Molecular Function: serine-type endopeptidase activity [IEA][NAS]
    peptidase activity [IMP][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLKWSLLLG TFVLISCSSV EAAVTVGRAC KVTDTMPGIC RTSSDCEPLI DGYIKSGVLT  60
   61 LNDVPSCGLG AWGEIFCCPT KPCCDNSTIT SVSTSSTTST KAPMTSGRVD VPTFGSGDRP 120
  121 AVAACKKIRE RKQQRSGNQL VIHIVGGYPV DPGVYPHMAA IGYITFGTDF RCGGSLIASR 180
  181 FVLTAAHCVN TDANTPAFVR LGAVNIENPD HSYQDIVIRS VKIHPQYVGN KYNDIAILEL 240
  241 ERDVVETDNI RPACLHTDAT DPPSNSKFFV AGWGVLNVTT RARSKILLRA GLELVPLDQC 300
  301 NISYAEQPGS IRLLKQGVID SLLCAIDQKL IADACKGDSG GPLIHELNVE DGMYTIMGVI 360
  361 SSGFGCATVT PGLYTRVSSY LDFIEGIVWP DNRV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..394] PSI-BLAST 58.0 Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • peptidase activity
    		•  5.91209560688646 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  5.52773635813967 bayes_pls_golite062009
  • serine hydrolase activity
    		•  5.5105092190926 bayes_pls_golite062009
  • serine-type peptidase activity
    		•  5.49703869306079 bayes_pls_golite062009
  • serine-type endopeptidase activity
    		•  5.39623690248556 bayes_pls_golite062009
  • endopeptidase activity
    		•  5.32070018460528 bayes_pls_golite062009
  • hydrolase activity
    		•  4.40346950809697 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.67153625234263 bayes_pls_golite062009
  • fucose binding
    		•  3.5000591397073 bayes_pls_golite062009
  • receptor activity
    		•  3.42551067912103 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.62896854217426 bayes_pls_golite062009
  • signal transducer activity
    		•  2.62896854217426 bayes_pls_golite062009
  • binding
    		•  2.46938749190409 bayes_pls_golite062009
  • protein binding
    		•  2.33752187704434 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.01328116441763 bayes_pls_golite062009
  • calcium-dependent protein binding
    		•  1.76058277614854 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73928761064649 bayes_pls_golite062009
  • ferritin receptor activity
    		•  1.69936564915558 bayes_pls_golite062009
  • DNA binding
    		•  1.61536775064425 bayes_pls_golite062009
  • protein kinase binding
    		•  1.49032409981537 bayes_pls_golite062009
  • heparin binding
    		•  1.48285358055737 bayes_pls_golite062009
  • kinase binding
    		•  1.45772799764228 bayes_pls_golite062009
  • thrombospondin receptor activity
    		•  1.44312413043539 bayes_pls_golite062009
  • polysaccharide binding
    		•  1.34665327732001 bayes_pls_golite062009
  • scavenger receptor activity
    		•  1.33287020047881 bayes_pls_golite062009
  • lipoprotein binding
    		•  1.24203139425173 bayes_pls_golite062009
  • serine-type aminopeptidase activity
    		•  0.964413112640311 bayes_pls_golite062009
  • growth factor activity
    		•  0.848900101748605 bayes_pls_golite062009
  • receptor binding
    		•  0.79054390509229 bayes_pls_golite062009
  • calcium ion binding
    		•  0.753095272942721 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  0.61937956382117 bayes_pls_golite062009
  • copper ion binding
    		•  0.581747195154861 bayes_pls_golite062009
  • enzyme binding
    		•  0.34047186937486 bayes_pls_golite062009
  • sodium channel regulator activity
    		•  0.30724450617383 bayes_pls_golite062009
  • catalytic activity
    		•  0.0690319239802181 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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