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View Structure Prediction Details

Protein: psh-PA
Organism: Drosophila melanogaster
Length: 394 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for psh-PA.

Description E-value Query
Range
Subject
Range
gi|109482418 - gi|109482418|ref|XP_001074604.1| PREDICTED: similar to Transmembrane protease, serine 6 (Matriptase-...
266.0 [0..18] [388..434]

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Predicted Domain #1
Region A:
Residues: [1-394]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPLKWSLLLG TFVLISCSSV EAAVTVGRAC KVTDTMPGIC RTSSDCEPLI DGYIKSGVLT  60
   61 LNDVPSCGLG AWGEIFCCPT KPCCDNSTIT SVSTSSTTST KAPMTSGRVD VPTFGSGDRP 120
  121 AVAACKKIRE RKQQRSGNQL VIHIVGGYPV DPGVYPHMAA IGYITFGTDF RCGGSLIASR 180
  181 FVLTAAHCVN TDANTPAFVR LGAVNIENPD HSYQDIVIRS VKIHPQYVGN KYNDIAILEL 240
  241 ERDVVETDNI RPACLHTDAT DPPSNSKFFV AGWGVLNVTT RARSKILLRA GLELVPLDQC 300
  301 NISYAEQPGS IRLLKQGVID SLLCAIDQKL IADACKGDSG GPLIHELNVE DGMYTIMGVI 360
  361 SSGFGCATVT PGLYTRVSSY LDFIEGIVWP DNRV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.0
Match: 1z8gA
Description: Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 5.91209560688646 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 5.52773635813967 bayes_pls_golite062009
serine hydrolase activity 5.5105092190926 bayes_pls_golite062009
serine-type peptidase activity 5.49703869306079 bayes_pls_golite062009
serine-type endopeptidase activity 5.39623690248556 bayes_pls_golite062009
endopeptidase activity 5.32070018460528 bayes_pls_golite062009
hydrolase activity 4.40346950809697 bayes_pls_golite062009
transmembrane receptor activity 3.67153625234263 bayes_pls_golite062009
fucose binding 3.5000591397073 bayes_pls_golite062009
receptor activity 3.42551067912103 bayes_pls_golite062009
molecular transducer activity 2.62896854217426 bayes_pls_golite062009
signal transducer activity 2.62896854217426 bayes_pls_golite062009
binding 2.46938749190409 bayes_pls_golite062009
protein binding 2.33752187704434 bayes_pls_golite062009
glycosaminoglycan binding 2.01328116441763 bayes_pls_golite062009
calcium-dependent protein binding 1.76058277614854 bayes_pls_golite062009
nucleic acid binding 1.73928761064649 bayes_pls_golite062009
ferritin receptor activity 1.69936564915558 bayes_pls_golite062009
DNA binding 1.61536775064425 bayes_pls_golite062009
protein kinase binding 1.49032409981537 bayes_pls_golite062009
heparin binding 1.48285358055737 bayes_pls_golite062009
kinase binding 1.45772799764228 bayes_pls_golite062009
thrombospondin receptor activity 1.44312413043539 bayes_pls_golite062009
polysaccharide binding 1.34665327732001 bayes_pls_golite062009
scavenger receptor activity 1.33287020047881 bayes_pls_golite062009
lipoprotein binding 1.24203139425173 bayes_pls_golite062009
serine-type aminopeptidase activity 0.964413112640311 bayes_pls_golite062009
growth factor activity 0.848900101748605 bayes_pls_golite062009
receptor binding 0.79054390509229 bayes_pls_golite062009
calcium ion binding 0.753095272942721 bayes_pls_golite062009
low-density lipoprotein binding 0.61937956382117 bayes_pls_golite062009
copper ion binding 0.581747195154861 bayes_pls_golite062009
enzyme binding 0.34047186937486 bayes_pls_golite062009
sodium channel regulator activity 0.30724450617383 bayes_pls_golite062009
catalytic activity 0.0690319239802181 bayes_pls_golite062009

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