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Protein Overview: scu-PA

General Information:
Name(s) found: scu-PA / FBpp0074285 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene scully is referred to in FlyBase by the symbol Dmel\scu (CG7113, FBgn0021765). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17985279..17986888. It has the cytological map location 16F6. There is experimental evidence that it has the molecular function</span>: steroid dehydrogenase activity; 7-beta-hydroxysteroid dehydrogenase (NADP+) activity; acetoacetyl-CoA reductase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity; testosterone 17-beta-dehydrogenase activity; estradiol 17-beta-dehydrogenase activity. There is experimental evidence that it is involved in the biological process</span>: acyl-CoA metabolic process; fatty acid metabolic process; estrogen metabolic process; androgen metabolic process; steroid metabolic process; ecdysone metabolic process. 14 alleles are reported. The phenotypes of these alleles are annotated with: testis; spermatocyte. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 255 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    mitochondrion [NAS]
    cytosol [NAS]
    Biological Process: acyl-CoA metabolic process [IDA]
    androgen metabolic process [IDA]
    estrogen metabolic process [IDA]
    steroid metabolic process [IDA]
    oxidation reduction [IEA]
    ecdysone metabolic process [IDA]
    fatty acid metabolic process [IDA]
    Molecular Function: 7-beta-hydroxysteroid dehydrogenase (NADP+) activity [IDA]
    estradiol 17-beta-dehydrogenase activity [IDA]
    steroid dehydrogenase activity [IDA]
    3-hydroxyacyl-CoA dehydrogenase activity [ISS][NAS]
    3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity [IDA]
    acetoacetyl-CoA reductase activity [IDA]
    binding [IEA]
    testosterone 17-beta-dehydrogenase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIKNAVSLVT GGASGLGRAT AERLAKQGAS VILADLPSSK GNEVAKELGD KVVFVPVDVT  60
   61 SEKDVSAALQ TAKDKFGRLD LTVNCAGTAT AVKTFNFNKN VAHRLEDFQR VININTVGTF 120
  121 NVIRLSAGLM GANEPNQDGQ RGVIVNTASV AAFDGQIGQA AYSASKAAVV GMTLPIARDL 180
  181 STQGIRICTI APGLFNTPML AALPEKVRTF LAKSIPFPQR LGEPSEYAHL VQAIYENPLL 240
  241 NGEVIRIDGA LRMMP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..255] PSI-BLAST 53.221849 Crystal Structure of ABAD/HSD10 with a Bound Inhibitor

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • retinol dehydrogenase activity
    		•  4.1750549780559 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • 3-hydroxyacyl-CoA dehydrogenase activity
    		•  3.06391460989761 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  3.02758902218302 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  2.66329970371321 bayes_pls_golite062009
  • ethanol binding
    		•  2.01597876952325 bayes_pls_golite062009
  • retinol binding
    		•  1.92497267707609 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.81060491890041 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • retinoid binding
    		•  1.72614743805853 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • isoprenoid binding
    		•  1.61095405873981 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • alcohol binding
    		•  1.51091775360793 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • fatty acid synthase activity
    		•  1.23679054027553 bayes_pls_golite062009
  • benzaldehyde dehydrogenase activity
    		•  1.05577641583555 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.05064033662208 bayes_pls_golite062009
  • receptor activity
    		•  1.02559644924534 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.973650203491298 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • signal transducer activity
    		•  0.832324207538104 bayes_pls_golite062009
  • 7-beta-hydroxysteroid dehydrogenase (NADP+) activity
    		•  0.695969796208571 bayes_pls_golite062009
  • retinal dehydrogenase activity
    		•  0.69372321031969 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.665447800395781 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • 3-oxoacyl-[acyl-carrier-protein] reductase activity
    		•  0.604742541607263 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.547974096538728 bayes_pls_golite062009
  • testosterone 17-beta-dehydrogenase activity
    		•  0.532187027260366 bayes_pls_golite062009
  • all-trans retinal binding
    		•  0.522435200991921 bayes_pls_golite062009
  • NADPH:quinone reductase activity
    		•  0.512538385530248 bayes_pls_golite062009
  • enoyl-CoA hydratase activity
    		•  0.439912268968251 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.407958284055066 bayes_pls_golite062009
  • DNA binding
    		•  0.302492036575815 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.179327587154303 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.177044638410302 bayes_pls_golite062009
  • methylenetetrahydrofolate dehydrogenase activity
    		•  0.124826575912808 bayes_pls_golite062009
  • methenyltetrahydrofolate cyclohydrolase activity
    		•  0.118312276550651 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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