Protein Overview: HDAC6-PA

General Information:
Name(s) found:	HDAC6-PA / FBpp0073825 [FlyBase]
Description(s) found: Found 37 descriptions. SHOW ALL	The gene HDAC6 is referred to in FlyBase by the symbol Dmel\HDAC6 (CG6170, FBgn0026428). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15226988..15234394. It has the cytological map location 13B6. There is experimental evidence that it has the molecular function</span>: histone deacetylase activity. There is experimental evidence that it is involved in the biological process</span>: histone deacetylation; regulation of transcription. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1128 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	histone deacetylation [IDA] regulation of transcription [IDA]
Molecular Function:	zinc ion binding [IEA] histone deacetylase activity [IDA][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPPIVTRRS AQQAKIQTRA MASKSKTGTT GAATAAGGTG SSSGSISGGF NAADPRKSNK  60
   61 PNAALLEAKR RARNNMLKNQ GCGSQESVTD IFQNAVNSKS LVRKPTALIY DESMSQHCCL 120
  121 WDKEHYECPE RFTRVLERCR ELNLTERCLE LPSRSATKDE ILRLHTEEHF ERLKETSGIR 180
  181 DDERMEELSS RYDSIYIHPS TFELSLLASG STIELVDHLV AGKAQNGMAI IRPPGHHAMK 240
  241 AEYNGYCFFN NVALATQHAL DVHKLQRILI IDYDVHHGQG TQRFFYNDPR VVYFSIHRFE 300
  301 HGSFWPHLHE SDYHAIGSGA GTGYNFNVPL NATGMTNGDY LAIFQQLLLP VALEFQPELI 360
  361 IVSAGYDAAL GCPEGEMEVT PACYPHLLNP LLRLADARVA VVLEGGYCLD SLAEGAALTL 420
  421 RSLLGDPCPP LVETVPLPRA ELAQALLSCI AVHRPHWRCL QLQQTYDCVE LQDRDKEEDL 480
  481 HTVLRHWIGG PPPMDRYPTR DTAIPLPPEK LTSNAARLQV LRAETKLSVP SFKVCYAYDA 540
  541 QMLLHCNLND TGHPEQPSRI QHIHKMHDDY GLLKQMKQLS PRAATTDEVC LAHTRAHVNT 600
  601 VRRLLGREPK ELHDAAGIYN SVYLHPRTFD CATLAAGLVL QAVDSVLRGE SRSGICNVRP 660
  661 PGHHAEQDHP HGFCIFNNVA IAAQYAIRDF GLERVLIVDW DVHHGNGTQH IFESNPKVLY 720
  721 ISLHRYEHGS FFPKGPDGNF DVVGKGAGRG FNVNIPWNKK GMGDLEYALA FQQLIMPIAY 780
  781 EFNPQLVLVS AGFDAAIGDP LGGCKVTAEG YGMLTHWLSA LASGRIIVCL EGGYNVNSIS 840
  841 YAMTMCTKTL LGDPVPTPQL GATALQKPPT VAFQSCVESL QQCLQVQRNH WRSLEFVGRR 900
  901 LPRDPVVGEN NNEDFLTASL RHLNISNDDA TAAAGGLAGD RPDCGDERPS GSKPKVKVKT 960
  961 LSDYLAENKE ALEQSEMFAV YPLKTCPHLR LLRPEEAPRS LDSGAECSVC GSTGENWVCL1020
 1021 SCRHVACGRY VNAHMEQHSV EEQHPLAMST ADLSVWCYAC SAYVDHPRLY AYLNPLHEDK1080
 1081 FQEPMAWTHG CAWREDGCYA TGPDGRDEDD DDDNGAGSSI CLRLERNN

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
protein deacetylase activity	12.8220438463909	bayes_pls_golite062009
histone deacetylase activity	12.6231784270509	bayes_pls_golite062009
deacetylase activity	11.5037545953213	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	9.39837596691907	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	5.91624581343504	bayes_pls_golite062009
agmatinase activity	3.73238467801147	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	3.35999169984456	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	3.35999169984456	bayes_pls_golite062009
histone methyltransferase activity (H3-K27 specific)	2.60243126690148	bayes_pls_golite062009
histone deacetylase activity (H3-K16 specific)	2.60243126690148	bayes_pls_golite062009
hydrolase activity	2.48411098726406	bayes_pls_golite062009
binding	1.80085909665797	bayes_pls_golite062009
catalytic activity	1.68836803454021	bayes_pls_golite062009
arginase activity	1.34373529002692	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	1.01223037319069	bayes_pls_golite062009
transcription factor binding	0.97845198395624	bayes_pls_golite062009
protein binding	0.932924391997764	bayes_pls_golite062009
transcription regulator activity	0.886023992169206	bayes_pls_golite062009
transcription repressor activity	0.59175938803562	bayes_pls_golite062009
nucleic acid binding	0.480948003342456	bayes_pls_golite062009
tubulin deacetylase activity	0.407658714311639	bayes_pls_golite062009
histone methyltransferase activity	0.396822865624511	bayes_pls_golite062009
DNA binding	0.20091997728132	bayes_pls_golite062009
chromatin binding	0.0976127981819213	bayes_pls_golite062009

No functions predicted.

Source: Reynolds et al. 2008. Manuscript submitted

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..519]	PSI-BLAST	108.0	No description for 2nvrA was found.
2	View Details	[520..870]	PSI-BLAST	66.0	HDAC homologue
3	View Details	[871..971]	deduced	N/A	No confident structure predictions are available.
4	View Details	[972..1128]	PSI-BLAST	24.39794	No description for 2g43A was found.

Protein Overview: HDAC6-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: