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View Structure Prediction Details

Protein: HDAC6-PA
Organism: Drosophila melanogaster
Length: 1128 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HDAC6-PA.

Description E-value Query
Range		 Subject
Range
HDAC6-PC - The gene HDAC6 is referred to in FlyBase by the symbol Dmel\HDAC6 (CG6170, FBgn0026428). It is a pro...
 997.0 [0..2] [1128..12]

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Predicted Domain #1
Region A:
Residues: [1-519] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPPIVTRRS AQQAKIQTRA MASKSKTGTT GAATAAGGTG SSSGSISGGF NAADPRKSNK  60
   61 PNAALLEAKR RARNNMLKNQ GCGSQESVTD IFQNAVNSKS LVRKPTALIY DESMSQHCCL 120
  121 WDKEHYECPE RFTRVLERCR ELNLTERCLE LPSRSATKDE ILRLHTEEHF ERLKETSGIR 180
  181 DDERMEELSS RYDSIYIHPS TFELSLLASG STIELVDHLV AGKAQNGMAI IRPPGHHAMK 240
  241 AEYNGYCFFN NVALATQHAL DVHKLQRILI IDYDVHHGQG TQRFFYNDPR VVYFSIHRFE 300
  301 HGSFWPHLHE SDYHAIGSGA GTGYNFNVPL NATGMTNGDY LAIFQQLLLP VALEFQPELI 360
  361 IVSAGYDAAL GCPEGEMEVT PACYPHLLNP LLRLADARVA VVLEGGYCLD SLAEGAALTL 420
  421 RSLLGDPCPP LVETVPLPRA ELAQALLSCI AVHRPHWRCL QLQQTYDCVE LQDRDKEEDL 480
  481 HTVLRHWIGG PPPMDRYPTR DTAIPLPPEK LTSNAARLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 2nvrA
Description: No description for 2nvrA was found.

Predicted Domain #2
Region A:
Residues: [520-870] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VLRAETKLSV PSFKVCYAYD AQMLLHCNLN DTGHPEQPSR IQHIHKMHDD YGLLKQMKQL  60
   61 SPRAATTDEV CLAHTRAHVN TVRRLLGREP KELHDAAGIY NSVYLHPRTF DCATLAAGLV 120
  121 LQAVDSVLRG ESRSGICNVR PPGHHAEQDH PHGFCIFNNV AIAAQYAIRD FGLERVLIVD 180
  181 WDVHHGNGTQ HIFESNPKVL YISLHRYEHG SFFPKGPDGN FDVVGKGAGR GFNVNIPWNK 240
  241 KGMGDLEYAL AFQQLIMPIA YEFNPQLVLV SAGFDAAIGD PLGGCKVTAE GYGMLTHWLS 300
  301 ALASGRIIVC LEGGYNVNSI SYAMTMCTKT LLGDPVPTPQ LGATALQKPP T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 66.0
Match: 1c3rA
Description: HDAC homologue
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein deacetylase activity 12.8220438463909 bayes_pls_golite062009
histone deacetylase activity 12.6231784270509 bayes_pls_golite062009
deacetylase activity 11.5037545953213 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 9.39837596691907 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 5.91624581343504 bayes_pls_golite062009
agmatinase activity 3.73238467801147 bayes_pls_golite062009
NAD-dependent protein deacetylase activity 3.35999169984456 bayes_pls_golite062009
NAD-dependent histone deacetylase activity 3.35999169984456 bayes_pls_golite062009
histone methyltransferase activity (H3-K27 specific) 2.60243126690148 bayes_pls_golite062009
histone deacetylase activity (H3-K16 specific) 2.60243126690148 bayes_pls_golite062009
hydrolase activity 2.48411098726406 bayes_pls_golite062009
binding 1.80085909665797 bayes_pls_golite062009
catalytic activity 1.68836803454021 bayes_pls_golite062009
arginase activity 1.34373529002692 bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines 1.01223037319069 bayes_pls_golite062009
transcription factor binding 0.97845198395624 bayes_pls_golite062009
protein binding 0.932924391997764 bayes_pls_golite062009
transcription regulator activity 0.886023992169206 bayes_pls_golite062009
transcription repressor activity 0.59175938803562 bayes_pls_golite062009
nucleic acid binding 0.480948003342456 bayes_pls_golite062009
tubulin deacetylase activity 0.407658714311639 bayes_pls_golite062009
histone methyltransferase activity 0.396822865624511 bayes_pls_golite062009
DNA binding 0.20091997728132 bayes_pls_golite062009
chromatin binding 0.0976127981819213 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [871-971] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VAFQSCVESL QQCLQVQRNH WRSLEFVGRR LPRDPVVGEN NNEDFLTASL RHLNISNDDA  60
   61 TAAAGGLAGD RPDCGDERPS GSKPKVKVKT LSDYLAENKE A

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [972-1128] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEQSEMFAVY PLKTCPHLRL LRPEEAPRSL DSGAECSVCG STGENWVCLS CRHVACGRYV  60
   61 NAHMEQHSVE EQHPLAMSTA DLSVWCYACS AYVDHPRLYA YLNPLHEDKF QEPMAWTHGC 120
  121 AWREDGCYAT GPDGRDEDDD DDNGAGSSIC LRLERNN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.39794
Match: 2g43A
Description: No description for 2g43A was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle