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Protein Overview: eag-PA

General Information:
Name(s) found: eag-PA / FBpp0073772 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene ether a go-go is referred to in FlyBase by the symbol Dmel\eag (CG10952, FBgn0000535). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:14865289..14899359. It has the cytological map location 13A2-13A5. There is experimental evidence that it has the molecular function</span>: voltage-gated cation channel activity. There is experimental evidence that it is involved in the biological process</span>: perineurial glial growth; learning or memory; flight behavior. 21 alleles are reported. The phenotypes of these alleles are annotated with: leg; neuromuscular junction; synapse; adult brain. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1174 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    voltage-gated potassium channel complex [ISS][TAS]
    Biological Process: potassium ion transport [IEA][TAS]
    transmembrane transport [IEA]
    flight behavior [IMP]
    two-component signal transduction system (phosphorelay) [IEA]
    courtship behavior [NAS][TAS]
    sensory perception of smell [NAS]
    perineurial glial growth [IGI]
    regulation of heart contraction [NAS]
    regulation of transcription, DNA-dependent [IEA]
    behavioral response to ether [NAS]
    learning or memory [IDA][NAS]
    Molecular Function: two-component sensor activity [IEA]
    voltage-gated potassium channel activity [IEA][TAS]
    voltage-gated cation channel activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGGRRGLVA PQNTFLENII RRSNSQPDSS FLLANAQIVD FPIVYCNESF CKISGYNRAE  60
   61 VMQKSCRYVC GFMYGELTDK ETVGRLEYTL ENQQQDQFEI LLYKKNNLQC GCALSQFGKA 120
  121 QTQETPLWLL LQVAPIRNER DLVVLFLLTF RDITALKQPI DSEDTKGVLG LSKFAKLARS 180
  181 VTRSRQFSAH LPTLKDPTKQ SNLAHMMSLS ADIMPQYRQE APKTPPHILL HYCAFKAIWD 240
  241 WVILCLTFYT AIMVPYNVAF KNKTSEDVSL LVVDSIVDVI FFIDIVLNFH TTFVGPGGEV 300
  301 VSDPKVIRMN YLKSWFIIDL LSCLPYDVFN AFDRDEDGIG SLFSALKVVR LLRLGRVVRK 360
  361 LDRYLEYGAA MLILLLCFYM LVAHWLACIW YSIGRSDADN GIQYSWLWKL ANVTQSPYSY 420
  421 IWSNDTGPEL VNGPSRKSMY VTALYFTMTC MTSVGFGNVA AETDNEKVFT ICMMIIAALL 480
  481 YATIFGHVTT IIQQMTSATA KYHDMLNNVR EFMKLHEVPK ALSERVMDYV VSTWAMTKGL 540
  541 DTEKVLNYCP KDMKADICVH LNRKVFNEHP AFRLASDGCL RALAMHFMMS HSAPGDLLYH 600
  601 TGESIDSLCF IVTGSLEVIQ DDEVVAILGK GDVFGDQFWK DSAVGQSAAN VRALTYCDLH 660
  661 AIKRDKLLEV LDFYSAFANS FARNLVLTYN LRHRLIFRKV ADVKREKELA ERRKNEPQLP 720
  721 QNQDHLVRKI FSKFRRTPQV QAGSKELVGG SGQSDVEKGD GEVERTKVFP KAPKLQASQA 780
  781 TLARQDTIDE GGEVDSSPPS RDSRVVIEGA AVSSATVGPS PPVATTSSAA AGAGVSGGPG 840
  841 SGGTVVAIVT KADRNLALER ERQIEMASSR ATTSDTYDTG LRETPPTLAQ RDLIATVLDM 900
  901 KVDVRLELQR MQQRIGRIED LLGELVKRLA PGAGSGGNAP DNSSGQTTPG DEICAGCGAG 960
  961 GGGTPTTQAP PTSAVTSPVD TVITISSPGA SGSGSGTGAG AGSAVAGAGG AGLLNPGATV1020
 1021 VSSAGGNGLG PLMLKKRRSK SRKAPAPPKQ TLASTAGTAT AAPAGVAGSG MTSSAPASAD1080
 1081 QQQQHQSTAD QSPTTPGAEL LHLRLLEEDF TAAQLPSTSS GGAGGGGGSG SGATPTTPPP1140
 1141 TTAGGSGSGT PTSTTATTTP TGSGTATRGK LDFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..76] PSI-BLAST 19.522879 Erg potassium channel, N-terminal domain
    2 View Details [77..430] PSI-BLAST 4.09691 No description for 2nyyA was found.
    3 View Details [431..516] FFAS03 3.7 No description for 2qksA was found.
    4 View Details [517..705] PSI-BLAST 42.69897 HCN2J 443-645 in the presence of cGMP
    5 View Details [706..854] deduced N/A No confident structure predictions are available.
    6 View Details [855..1174] PSI-BLAST 41.69897 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • substrate-specific transmembrane transporter activity
    		•  2.4673993239115 bayes_pls_golite062009
  • binding
    		•  1.56259855231916 bayes_pls_golite062009
  • transporter activity
    		•  1.29150662073327 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07075219961504 bayes_pls_golite062009
  • amine binding
    		•  0.947632395806172 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.801327928563072 bayes_pls_golite062009
  • signal transducer activity
    		•  0.705049527437737 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.705049527437737 bayes_pls_golite062009
  • protein binding
    		•  0.657665757061848 bayes_pls_golite062009
    		• 0.394278984078131 bayes_pls_golite062009
  • channel regulator activity
    		•  0.37785202181286 bayes_pls_golite062009
  • receptor activity
    		•  0.286006388683751 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.0601638402237312 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • metal ion transmembrane transporter activity
    		•  10.0964834385956 bayes_pls_golite062009
  • cation channel activity
    		•  9.88287212109635 bayes_pls_golite062009
  • ion channel activity
    		•  9.4846197809463 bayes_pls_golite062009
  • channel activity
    		•  9.25176207085973 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  9.25176207085973 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  9.2472549851376 bayes_pls_golite062009
  • intracellular cGMP activated cation channel activity
    		•  9.19973076787954 bayes_pls_golite062009
  • gated channel activity
    		•  9.19042473454294 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  8.67936023319976 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  8.65591260847522 bayes_pls_golite062009
  • potassium channel activity
    		•  8.63993986153386 bayes_pls_golite062009
  • cGMP binding
    		•  7.7575871125398 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  7.73925918789438 bayes_pls_golite062009
  • intracellular cyclic nucleotide activated cation channel activity
    		•  7.4836902710921 bayes_pls_golite062009
  • cyclic nucleotide-gated ion channel activity
    		•  7.4836902710921 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  7.41584542512987 bayes_pls_golite062009
  • cyclic nucleotide binding
    		•  7.37322432929433 bayes_pls_golite062009
  • intracellular ligand-gated ion channel activity
    		•  7.28268657394688 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  6.98507387897677 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  5.54400173845933 bayes_pls_golite062009
  • GMP binding
    		•  5.49455172024846 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  5.34760703274696 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  5.1138025954757 bayes_pls_golite062009
  • transporter activity
    		•  3.30740141256752 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.24402760485462 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.22443361822344 bayes_pls_golite062009
  • intracellular cAMP activated cation channel activity
    		•  1.73579819368652 bayes_pls_golite062009
  • binding
    		•  1.39247933044015 bayes_pls_golite062009
  • signal transducer activity
    		•  0.758143612871078 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.758143612871078 bayes_pls_golite062009
  • protein binding
    		•  0.71319432010926 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.263984709287237 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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