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Protein Overview: Gtp-bp-PA

General Information:
Name(s) found: Gtp-bp-PA / FBpp0073336 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene GTP-binding protein is referred to in FlyBase by the symbol Dmel\Gtp-bp (CG2522, FBgn0010391). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11020908..11023136. It has the cytological map location 10A6. Based on sequence similarity, it is predicted to have molecular function</span>: signal recognition particle binding. There is experimental evidence that it is involved in the biological process</span>: regulation of protein secretion; axonogenesis. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 614 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDA]
    lipid particle [IDA]
    signal recognition particle receptor complex [ISS]
    Biological Process: SRP-dependent cotranslational protein targeting to membrane [IEA]
    regulation of protein secretion [IEP]
    axonogenesis [IEP]
    Molecular Function: GTP binding [IEA][NAS]
    protein binding [IEA]
    GTPase activity [IEA]
    mRNA binding [NAS]
    signal recognition particle binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDFVVIFTK GGVVLWHSNA SGNSFASCIN SLIRGVILEE RNTEAKYYEE DHLAVQFKLD  60
   61 NELDLVYAAI FQKVIKLNYL DGFLADMQAA FKEKYGDIRL GDDYDFDREY RRVLSAAEEA 120
  121 SAKQVKAPKT MRSYNESQKS KKTVASMIQD DKKPVEKRVN IQEAPPPSKS QPSSPPTGSP 180
  181 MDKIIMEKRR KLREKLTPTK KTSPSDSKSS KPEKAGKKPR VWDLGGNSKD AALLDRSRDS 240
  241 PDDVQYQNIN SELVGTMQGV IRDLDVESED EADNEDASSE GEAEEQVQSK KGKRGGLLSY 300
  301 FKGIVGAKTM SLADLQPALE KMRDHLISKN VASEIAAKLC DSVAASLDGK QMGTFDSIAS 360
  361 QVKEALTESL VRILSPKRRI DIIRDALESK RNGRPYTIIF CGVNGVGKST NLAKICFWLI 420
  421 ENDFNVLIAA CDTFRAGAVE QLRTHTRHLN ALHPAAKHDG RNMVQLYEKG YGKDAAGIAM 480
  481 EAIKFAHDTR VDVVLVDTAG RMQDNEPLMR SLSKLIKVNN PDLVLFVGEA LVGNEAVDQL 540
  541 VKFNQSLADY SSNENPHIID GIVLTKFDTI DDKVGAAISM TYITGQPIVF VGTGQTYADL 600
  601 KAINVNAVVN SLMK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] PSI-BLAST 39.522879 The Structure of the Mammalian SRP Receptor
    2 View Details [107..497] PSI-BLAST 28.522879 Crystal Structure Analysis of ClpB
    3 View Details [498..614] PSI-BLAST 62.69897 No description for 2j289 was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • signal recognition particle binding
    		•  6.13359612945359 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  3.69979261496156 bayes_pls_golite062009
  • palmitoyltransferase activity
    		•  2.05869539883473 bayes_pls_golite062009
  • protein transporter activity
    		•  2.04806587835812 bayes_pls_golite062009
  • transporter activity
    		•  1.71943098913274 bayes_pls_golite062009
  • binding
    		•  1.53365041260926 bayes_pls_golite062009
  • SNAP receptor activity
    		•  1.47915598483249 bayes_pls_golite062009
  • protein-cysteine S-palmitoleyltransferase activity
    		•  1.21320139992612 bayes_pls_golite062009
  • protein-cysteine S-acyltransferase activity
    		•  1.21320139992612 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.939682472116899 bayes_pls_golite062009
  • protein binding
    		•  0.690762864611134 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.131410992694836 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0936690070284361 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0846345824909659 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0820309452260982 bayes_pls_golite062009
    2
    Term Confidence Notes
  • signal recognition particle binding
    		•  5.12760449152779 bayes_pls_golite062009
  • ribonucleoprotein binding
    		•  3.19511216911452 bayes_pls_golite062009
  • transporter activity
    		•  3.10463051760206 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.95886887664984 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.95079405147356 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.87427509025394 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.85499564954033 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.85178667290149 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  2.61775212528604 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  2.61467977505707 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  2.57552435627908 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  2.57107347424517 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  2.57054427875021 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  2.50494515048649 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.43862163407966 bayes_pls_golite062009
  • ATPase activity
    		•  2.39535714892224 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.91091452720653 bayes_pls_golite062009
  • protein transporter activity
    		•  1.71214667007262 bayes_pls_golite062009
  • hydrolase activity
    		•  1.57549510726226 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  1.56325751172863 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.977237423302079 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.929901285538132 bayes_pls_golite062009
  • nucleotide binding
    		•  0.922442819194247 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.920987930180051 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.920926158369519 bayes_pls_golite062009
  • motor activity
    		•  0.87979065815418 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.640772201693186 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.63468044350616 bayes_pls_golite062009
  • GTP binding
    		•  0.621689261700018 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.557919489256916 bayes_pls_golite062009
  • GTPase activity
    		•  0.437665353870877 bayes_pls_golite062009
  • ATP binding
    		•  0.41092997612902 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.385813421701492 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.377870145186619 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • signal transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  0.213018989352421 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.194779852865789 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.123304946374679 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  0.0775601177068852 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle