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Protein Overview: FBpp0309145, Smox-PA

General Information:
Name(s) found: FBpp0309145 [FlyBase]
Smox-PA / FBpp0071140 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • type=protein; loc=X:complement(8033255..8034715); ID=FBpp0309145; name=Smox-PB; parent=FBgn0025800,FBtr0340159; dbxref=FlyBase:FBpp0309145,FlyBase_Annotation_IDs:CG2262-PB; MD5=312ffdf2d81998a7b36cf28e97020d29; length=486; release=r5.56; species=Dmel; [FlyBase]
  • The gene Smad on X is referred to in FlyBase by the symbol Dmel\Smox (CG2262, FBgn0025800). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:8032405..8036274. It has the cytological map location 7D14-7D15. Based on sequence similarity, it is predicted to have molecular function</span>: transforming growth factor beta receptor, cytoplasmic mediator activity. There is experimental evidence that it is involved in the biological process</span>: axon guidance; neuron development; regulation of mitotic cell cycle; mushroom body development; imaginal disc-derived wing morphogenesis. 14 alleles are reported. The phenotypes of these alleles are annotated with: medulla neuropil; lamina anlage glial cell; medulla glial cell; larval inner optic anlage; larval outer optic anlage; chaeta; wing; lamina. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 486 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [IEA]
    Biological Process: mushroom body development [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    transforming growth factor beta receptor signaling pathway [IEA]
    regulation of transcription, DNA-dependent [IEA]
    axon guidance [IMP]
    neuron development [IMP]
    regulation of mitotic cell cycle [IMP]
    dendrite morphogenesis [NAS]
    Molecular Function: transcription factor activity [IEA]
    protein binding [IEA]
    transforming growth factor beta receptor, cytoplasmic mediator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPFTPQVVK RLLALKKGNE DNSVEGKWSE KAVKNLVKKI KKNSQLEELE RAISTQNCQT  60
   61 RCVTVPRSKP APAGEHLRKG LPHVIYCRLW RWPDLQSQNE LKPLDHCEYA FHLRKEEICI 120
  121 NPYHYKKIEL SILVPKSLPT PPDSIVDYPL DNHTHQIPNN TDYNAAIIRS ASLSPPQYME 180
  181 LGGAGPVSVS SSASSTPATA AGGGGGPSSS SSSSSSAASA YQQQQQQLSF GQNMDSQSSV 240
  241 LSVGSSIPNT GTPPPGYMSE DGDPIDPNDN MNMSRLTPPA DAAPVMYHEP AFWCSISYYE 300
  301 LNTRVGETFH ASQPSITVDG FTDPSNSERF CLGLLSNVNR NEVVEQTRRH IGKGVRLYYI 360
  361 GGEVFAECLS DSSIFVQSPN CNQRYGWHPA TVCKIPPGCN LKIFNNQEFA ALLSQSVSQG 420
  421 FEAVYQLTRM CTIRMSFVKG WGAEYRRQTV TSTPCWIELH LNGPLQWLDR VLTQMGSPRL 480
  481 PCSSMS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] PSI-BLAST 54.30103 SMAD MH1 domain
    2 View Details [121..240] deduced N/A No confident structure predictions are available.
    3 View Details [241..486] PSI-BLAST 94.39794 Smad2 MH2 domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • R-SMAD binding
    		•  5.38307893104629 bayes_pls_golite062009
  • transforming growth factor beta receptor, cytoplasmic mediator activity
    		•  5.17758651944685 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase signaling protein activity
    		•  4.95270065635384 bayes_pls_golite062009
  • co-SMAD binding
    		•  4.57538059815089 bayes_pls_golite062009
  • transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
    		•  4.49077041445033 bayes_pls_golite062009
  • SMAD binding
    		•  4.23556933524744 bayes_pls_golite062009
  • binding
    		•  3.6561903894619 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.49687772656017 bayes_pls_golite062009
  • protein binding
    		•  3.44553762357492 bayes_pls_golite062009
  • DNA binding
    		•  3.30334070294767 bayes_pls_golite062009
  • type I transforming growth factor beta receptor binding
    		•  3.25693690222359 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.21526555447097 bayes_pls_golite062009
  • transcription activator activity
    		•  2.94935902482394 bayes_pls_golite062009
  • receptor serine/threonine kinase binding
    		•  2.94401714632865 bayes_pls_golite062009
  • signal transducer activity
    		•  2.90288654612667 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.90288654612667 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.88406197124131 bayes_pls_golite062009
  • activin binding
    		•  2.85561990563659 bayes_pls_golite062009
  • transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
    		•  2.75979335370845 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  2.63051531362977 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.61166537801555 bayes_pls_golite062009
  • transmembrane receptor protein serine/threonine kinase binding
    		•  2.57320437127906 bayes_pls_golite062009
  • transforming growth factor beta receptor binding
    		•  2.57320437127906 bayes_pls_golite062009
  • phosphatase activity
    		•  2.46582579847871 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.41505949322677 bayes_pls_golite062009
  • promoter binding
    		•  2.30493918456602 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.1294440466744 bayes_pls_golite062009
  • transcription factor activity
    		•  2.08449567315174 bayes_pls_golite062009
  • collagen binding
    		•  1.9825610927799 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.74929788315626 bayes_pls_golite062009
  • chromatin binding
    		•  1.44267609273288 bayes_pls_golite062009
  • receptor binding
    		•  1.1261895404991 bayes_pls_golite062009
  • transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
    		•  1.02877533969699 bayes_pls_golite062009
  • histone binding
    		•  1.01074250987871 bayes_pls_golite062009
  • transcription factor binding
    		•  0.95553719139833 bayes_pls_golite062009
  • ubiquitin protein ligase binding
    		•  0.85140744915405 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.849282290562727 bayes_pls_golite062009
  • kinase activity
    		•  0.818037815854114 bayes_pls_golite062009
  • protein kinase activity
    		•  0.658065106914619 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.657115605255247 bayes_pls_golite062009
  • I-SMAD binding
    		•  0.605133087848961 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.408522209269307 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.372418193032456 bayes_pls_golite062009
  • enzyme binding
    		•  0.34998623523914 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.33340925100096 bayes_pls_golite062009
  • transferase activity
    		•  0.294538857017548 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.242323296067 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.163947452198109 bayes_pls_golite062009
  • specific transcriptional repressor activity
    		•  0.15013949452504 bayes_pls_golite062009
  • identical protein binding
    		•  0.0513801649373811 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.0339057097360133 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle