Protein Overview: Spt6-PA, FBpp0309041

General Information:
Name(s) found:	FBpp0309041 [FlyBase] Spt6-PA / FBpp0070861 [FlyBase]
Description(s) found: Found 27 descriptions. SHOW ALL	type=protein; loc=X:join(6161940..6161978,6162140..6162224,6162800..6163005,6163158..6163277,6163347..6163498,6163564..6168457); ID=FBpp0309041; name=Spt6-PB; parent=FBgn0028982,FBtr0340027; dbxref=FlyBase:FBpp0309041,FlyBase_Annotation_IDs:CG12225-PB; MD5=8195266579396006d5c24707880bbaca; length=1831; release=r5.56; species=Dmel; [FlyBase] The gene Spt6 is referred to in FlyBase by the symbol Dmel\Spt6 (CG12225, FBgn0028982). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6161847..6169019. It has the cytological map location 5E4. Based on sequence similarity, it is predicted to have molecular function</span>: chromatin binding. There is experimental evidence that it is involved in the biological process</span>: transcription from RNA polymerase II promoter. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1831 amino acids
Gene Ontology:
Cellular Component:	polytene chromosome [IDA] nuclear exosome (RNase complex) [IPI] polytene chromosome puff [IDA] polytene chromosome interband [IDA]
Biological Process:	RNA elongation [NAS] transcription from RNA polymerase II promoter [IEP] nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA] regulation of transcription from RNA polymerase II promoter [IEA]
Molecular Function:	hydrolase activity, acting on ester bonds [IEA] transcription elongation regulator activity [IEA][NAS] protein binding [IEA] RNA binding [IEA] chromatin binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEFLDSEAE ESEEEEELDV NERKRLKKLK AAVSDSSEEE EDDEERLREE LKDLIDDNPI  60
   61 EEDDGSGYDS DGVGSGKKRK KHEDDDLDDR LEDDDYDLIE ENLGVKVERR KRFKRLRRIH 120
  121 DNESDGEEQH VDEGLVREQI AEQLFDENDE SIGHRSERSH READDYDDVD TESDADDFIV 180
  181 DDNGRPIAEK KKKRRPIFTD ASLQEGQDIF GVDFDYDDFS KYEEDDYEDD SEGDEYDEDL 240
  241 GVGDDTRVKK KKALKKKVVK KTIFDIYEPS ELKRGHFTDM DNEIRKTDIP ERMQLREVPV 300
  301 TPVPEGSDEL DLEAEWIYKY AFCKHTVSEQ EKPESREKMR KPPTTVNKIK QTLEFIRNQQ 360
  361 LEVPFIAFYR KEYVKPELNI DDLWKVYYYD GIWCQLNERK RKLKVLFEKM RQFQLDTLCA 420
  421 DTDQPVPDDV RLILDSDFER LADVQSMEEL KDVHMYFLLN YSHELPRMQA EQRRKAIQER 480
  481 REAKARRQAA AAENGDDAAE AIVVPEPEDD DDPELIDYQL KQASNSSPYA VFRKAGICGF 540
  541 AKHFGLTPEQ YAENLRDNYQ RNEITQESIG PTELAKQYLS PRFMTTDEVI HAAKYVVARQ 600
  601 LAQEPLLRKT MREVYFDRAR INIRPTKNGM VLIDENSPVY SMKYVAKKPV SDLFGDQFIK 660
  661 LMMAEEEKLL EITFLEEFEG NACANGTPGD YVEESKALYQ LDQFAKHVQE WNKLRAECVQ 720
  721 LALQKWVIPD LIKELRSTLH EEAQQFVLRS CTGKLYKWLK VAPYKPQLPP DFGYEEWSTL 780
  781 RGIRVLGLAY DPDHSVAAFC AVTTVEGDIS DYLRLPNILK RKNSYNLEEK AQKLADLRKL 840
  841 SDFIKMKKPH IVVIGAESRD AQNIQADIKE ILHELETSEQ FPPIEVEIID NELAKIYANS 900
  901 KKGESDFKEY PPLLKQAASL ARKMQDPLVE YSQLCDADDE ILCLRYHPLQ ERVPREQLLE 960
  961 QLSLQFINRT SEVGLDINLM VQNSRTINLL QYICGLGPRK GQALLKLLKQ SNQRLENRTQ1020
 1021 LVTVCHLGPR VFINCSGFIK IDTSSLGDST EAYVEVLDGS RVHPETYEWA RKMAIDAMEY1080
 1081 DDEETNPAGA LEEILESPER LKDLDLDAFA VELERQGFGS KSITLYDIRN ELSCLYKDYR1140
 1141 TPYTKPSAEE LFDMLTKETP DSFYVGKCVT AMVTGFTYRR PQGDQLDSAN PVRLDSNESW1200
 1201 QCPFCHKDDF PELSEVWNHF DANACPGQPS GVRVRLENGL PGFIHIKNLS DRQVRNPEER1260
 1261 VRVSQMIHVR IIKIDIDRFS VECSSRTADL KDVNNEWRPR RDNYYDYVTE EQDNRKVSDA1320
 1321 KARALKRKIY ARRVIAHPSF FNKSYAEVVA MLAEADQGEV ALRPSSKSKD HLTATWKVAD1380
 1381 DIFQHIDVRE EGKENDFSLG RSLWIGTEEF EDLDEIIARH IMPMALAARE LIQYKYYKPN1440
 1441 MVTGDENERD VMEKLLREEK ANDPKKIHYF FTASRAMPGK FLLSYLPKTK VRHEYVTVMP1500
 1501 EGYRFRGQIF DTVNSLLRWF KEHWLDPTAT PASASASNLT PLHLMRPPPT ISSSSQTSLG1560
 1561 PQAPYSVTGS VTGGTPRSGI SSAVGGGGSS AYSITQSITG YGTSGSSAPG AGVSSSHYGS1620
 1621 SSTPSFGAIN TPYTPSGQTP FMTPYTPHAS QTPRYGHNVP SPSSQSSSSQ RHHYGSSSGT1680
 1681 GSTPRYHDMG GGGGGGVGGG GGSNAYSMQP HHQQRAKENL DWQLANDAWA RRRPQQHQSH1740
 1741 QSYHAQQQHH HSQQQPHMGM SMNMGITMSL GRGTGGGGGG GYGSTPVNDY STGGGHNRGM1800
 1801 SSKASVRSTP RTNASPHSMN LGDATPLYDE N

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Searching the YRC Public Image Repository, found results:

Currently showing to of results.

[View Search in the YRC Public Image Repository]

Searching the YRC Public Image Repository, found no results.

Ginzu Version Information

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
ribonuclease activity	4.78408578264511	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	4.47575558124516	bayes_pls_golite062009
exoribonuclease activity	4.45956182921702	bayes_pls_golite062009
3'-5'-exoribonuclease activity	3.99660019081433	bayes_pls_golite062009
nucleic acid binding	3.87899047526266	bayes_pls_golite062009
3'-5' exonuclease activity	3.51306349336452	bayes_pls_golite062009
DNA binding	3.47278447192966	bayes_pls_golite062009
binding	3.35781855253373	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	3.07263153665399	bayes_pls_golite062009
exonuclease activity	2.66053639652924	bayes_pls_golite062009
structural constituent of ribosome	2.13063800565247	bayes_pls_golite062009
transcription regulator activity	2.10110937001387	bayes_pls_golite062009
structural molecule activity	1.9177190829469	bayes_pls_golite062009
structure-specific DNA binding	1.81524862921454	bayes_pls_golite062009
single-stranded DNA binding	1.62996999055328	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.36224060256697	bayes_pls_golite062009
excinuclease ABC activity	1.24466762466323	bayes_pls_golite062009
endonuclease activity	0.991569665925888	bayes_pls_golite062009
damaged DNA binding	0.95191912850966	bayes_pls_golite062009
transcription factor activity	0.937752547283357	bayes_pls_golite062009
sequence-specific DNA binding	0.76825863122436	bayes_pls_golite062009
protein binding	0.767256907671421	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.708753843279937	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.598360955770972	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.583085644017496	bayes_pls_golite062009
nuclease activity	0.57381531077345	bayes_pls_golite062009
translation regulator activity	0.515576958825022	bayes_pls_golite062009
DNA-directed RNA polymerase activity	0.510809870824979	bayes_pls_golite062009
RNA polymerase activity	0.510809870824979	bayes_pls_golite062009
translation factor activity, nucleic acid binding	0.468402630523277	bayes_pls_golite062009
telomeric DNA binding	0.361382760487809	bayes_pls_golite062009
deoxyribonuclease activity	0.24906263529692	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.233952169113693	bayes_pls_golite062009
translation initiation factor activity	0.2080607201312	bayes_pls_golite062009
RNA binding	0.18502033889261	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.09423425042945	bayes_pls_golite062009
DNA polymerase activity	0.0189279348688405	bayes_pls_golite062009
endoribonuclease activity	0.016619833072142	bayes_pls_golite062009
chromatin binding	0.0075451629397203	bayes_pls_golite062009

Term	Confidence	Notes
binding	3.53841763802611	bayes_pls_golite062009
protein binding	2.59400723645972	bayes_pls_golite062009
transcription regulator activity	2.33050919783116	bayes_pls_golite062009
DNA binding	1.69194220365195	bayes_pls_golite062009
nucleic acid binding	1.68849923149905	bayes_pls_golite062009
transcription factor activity	1.02720628759707	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.364108622844773	bayes_pls_golite062009

No functions predicted.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..359]	PSI-BLAST	30.30103	Heavy meromyosin subfragment
2	View Details	[360..420]	deduced	N/A	No confident structure predictions are available.
3	View Details	[421..1336]	PSI-BLAST	1000.0	No description for 2oceA was found.
4	View Details	[1337..1474]	FFAS03	3.91	The Xlp protein Sap
5	View Details	[1475..1831]	PSI-BLAST	12.221849	No description for 1y0fB was found.

Protein Overview: Spt6-PA, FBpp0309041

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: