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Protein Overview: Sirt4-PC

General Information:
Name(s) found: Sirt4-PC / FBpp0070817 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene Sirt4 is referred to in FlyBase by the symbol Dmel\Sirt4 (CG3187, FBgn0029783). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:5558661..5560002. It has the cytological map location 5A10. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; zinc ion binding; NAD binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: protein amino acid deacetylation; chromatin silencing. 3 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: protein amino acid deacetylation [IEA]
    chromatin silencing [IEA]
    regulation of transcription [IEA]
    Molecular Function: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [IEA]
    zinc ion binding [IEA]
    NAD binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRVGQLLRFR STSLRSSTAR QEYVPHHKPV VEDDIKRLED FLLSKPNVLV LTGAGISTES  60
   61 GIPDYRSEGV GLYARSNHKP VQHMEFVKSS AVRKRYWARN FVGWPKFSAT QPNATHHALA 120
  121 RFEREERVQA VVTQNVDRLH TKAGSRNVVE VHGSGYVVKC LSCEYRIDRH EFQSILASLN 180
  181 PAFKDAPDMI RPDGDVEIPL EYIENFRIPE CTQCGGDLKP EIVFFGDSVP RPRVDQIAGM 240
  241 VYNSDGLLVL GSSLLVFSGY RVVLQTKDLK LPVGIVNIGE TRADHLADIK ISAKCGDVIP 300
  301 KLFDFRNSKS VS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..312] PSI-BLAST 69.30103 AF0112, Sir2 homolog (Sir2-AF2)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NAD-dependent histone deacetylase activity
    		•  4.66387831647923 bayes_pls_golite062009
  • NAD-dependent protein deacetylase activity
    		•  4.66387831647923 bayes_pls_golite062009
  • NAD+ ADP-ribosyltransferase activity
    		•  4.62921662347995 bayes_pls_golite062009
  • histone deacetylase activity
    		•  4.52265070993834 bayes_pls_golite062009
  • protein deacetylase activity
    		•  4.51418609991523 bayes_pls_golite062009
  • deacetylase activity
    		•  3.60611826633675 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.31731368009317 bayes_pls_golite062009
  • DNA binding
    		•  1.84059392605809 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.83132687449755 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.74876325396581 bayes_pls_golite062009
  • binding
    		•  1.63619372613603 bayes_pls_golite062009
  • hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
    		•  1.38412624618353 bayes_pls_golite062009
  • transcription corepressor activity
    		•  1.16656035070431 bayes_pls_golite062009
  • transporter activity
    		•  1.02987325768951 bayes_pls_golite062009
  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity
    		•  0.963519974868694 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.879539673228343 bayes_pls_golite062009
  • transcription factor activity
    		•  0.758967814548108 bayes_pls_golite062009
  • catalytic activity
    		•  0.739210399081789 bayes_pls_golite062009
  • transcription factor binding
    		•  0.64778523540991 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.62029498163975 bayes_pls_golite062009
  • histone binding
    		•  0.60825982588532 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.56000396203236 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.52020182886741 bayes_pls_golite062009
  • protein binding
    		•  0.475479132768057 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.47231237137431 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.128843577740998 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0875567934348688 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.05634462944063 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle