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Protein Overview: Ptp4E-PB

General Information:
Name(s) found: Ptp4E-PB / FBpp0070693 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Protein tyrosine phosphatase 4E is referred to in FlyBase by the symbol Dmel\Ptp4E (CG6899, FBgn0004368). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4833165..4849458. It has the cytological map location 4D7. Based on sequence similarity, it is predicted to have molecular function</span>: transmembrane receptor protein tyrosine phosphatase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid dephosphorylation. 9 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1607 amino acids

    Gene Ontology:
    Cellular Component: neuronal cell body [IDA]
    plasma membrane [ISS]
    axon [IDA]
    Biological Process: central nervous system development [IGI]
    motor axon guidance [IGI]
    protein amino acid dephosphorylation [IEA][ISS][NAS]
    open tracheal system development [IGI]
    Molecular Function: protein tyrosine phosphatase activity [IEA][NAS]
    transmembrane receptor protein tyrosine phosphatase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDCATRKQQQ LRAHHQQQQI QIQTHGRKRQ QLQKQRHNHH HYYQNSQQQQ KHFVWLVVGI  60
   61 LTIFLAQHAN AADLVINVPN ASSNANAFYR IDYSPPFGFP EPNTTIPASD IGKDIKFSRA 120
  121 LPGTEYNFWL YYTNSTHREQ LTWTVNITTA PDPPANLSVQ LRSSKSAFIT WRPPGSGRYS 180
  181 GFRIRVLGLT DLPFERSYSL EGNETLQLSA KELTPGGSYQ VQAYSVYQGK ESVAYTSRNF 240
  241 TTKPNTPGKF IVWFRNETTL LVLWQPPFPA GIYTHYRVSI TPDDAIQSVL YVEREGEPPG 300
  301 PAQAAFKGLV PGREYNISVQ TVSEDETSSV PTTARYLTVP ERVLNVTFDE AYTTSSSFRV 360
  361 RWEPPRTYSE FDAYQVMLST SRRIFNVPRA ANGDSVYFDY PDILEPGRTY EVVVKTIADN 420
  421 VNSWPASGEV TLRPRPVRSL GGFLDDRSNA LHISWEPAET GRQDSYRISY HEQTNASEVP 480
  481 APFPVAAESQ ITTNLTEYTL DSLLAGRRYL IAVQALSKGV ASNASDITRY TRPAAPLIQE 540
  541 LRSIDQGLML SWRSDVNSRQ DRYEVHYQRN GTREERTMAT NETSLTIHYL HPGSGYEVKV 600
  601 HAISHGVRSE PHSYFQAVFP KPPQNLTLQT VHTNLVVLHW QAPEGSDFSE YVVRYRTDAS 660
  661 PWQRISGLHE NEARIKDMHY GERYLVQVNT VSFGVESPHP LELNVTMPPQ PVSNVVPLVD 720
  721 SRNLTLEWPR PDGHVDFYTL KWWPTDEEDR VEFKNVTQLE DLSSPSVRIP IEDLSPGRQY 780
  781 RFEVQASSNG IRSGTTHLST RTMPLIQSDV FIANAGHEQG QDETITLSYT PTPADSTRFD 840
  841 IYRFSMGDPT IKDKEKLAND TERKLSFSGL TPGKLYNVTV WTVSGGVASL PVQRLYRLHP 900
  901 LPISDLKAIQ VAAREITLHW TAPAGEYTDF ELQYLSADEE APQLLQNVTK NTEITLQGLR 960
  961 PYHNYTFTVV VRSGSIQGTD FADVSVSTLM RSSAPISASY QTLTAPPGKV DYFQPSDVQP1020
 1021 GEVTFEWSLE PAEQHGPIDY FRITCQNADD AADVSSYEFP VNATQGKIDG LVPGNHYIFR1080
 1081 IQAKSALGYG AEREHIQTMP ILAPPVPEPS VTPLEVSRTS STIEISFRQG YFSNAHGMVR1140
 1141 SYTIIIAEDV GKNASGLEMP SWQDVQAYTV WLPYQAIEPY NPFLTSNGSR KSSLEAEHFT1200
 1201 IGTANCDKHQ AGYCNGPLRA GTTYRIKIRA FTDEDKFTDT VYSSPITTER SDTVIVAATV1260
 1261 SAVLLVAMVL VVVYCQHRCQ LIRRASKLAR MQDELAALPE GYITPNRPVH VKDFSEHYRI1320
 1321 MSADSDFRFS EEFEELKHVG RDQACSFANL PCNRPKNRFT NILPYDHSRF KLQPVDDDDG1380
 1381 SDYINANYMP GHNSPREFIV TQGPLHSTRE EFWRMCWESN SRAIVMLTRC FEKGREKCDQ1440
 1441 YWPVDRVAMF YGDIKVQLII DTHYHDWSIS EFMVSRNCES RIMRHFHFTT WPDFGVPEPP1500
 1501 QSLVRFVRAF RDVIGTDMRP IIVHCSAGVG RSGTFIALDR ILQHIHKSDY VDIFGIVFAM1560
 1561 RKERVFMVQT EQQYVCIHQC LLAVLEGKEH LLADSLELHA NDGYEVL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..521] PSI-BLAST 47.0 No description for 2v5yA was found.
    2 View Details [522..632] PSI-BLAST 50.69897 FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
    3 View Details [633..694] PSI-BLAST 11.522879 The solution structure of the second fibronectin type III domain of human Neogenin
    4 View Details [695..886] PSI-BLAST 10.0 Prolactin receptor
    5 View Details [887..989] PSI-BLAST 38.045757 Fibronectin, different Fn3 modules
    6 View Details [990..1121] PSI-BLAST 3.522879 No description for 2jixB was found.
    7 View Details [1122..1280] FFAS03 2.13 No description for 2e7hA was found.
    8 View Details [1281..1607] PSI-BLAST 94.154902 No description for 2gjtA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • transmembrane receptor activity
    		•  4.21125462030555 bayes_pls_golite062009
  • receptor activity
    		•  4.09185309744435 bayes_pls_golite062009
  • protein binding
    		•  3.24522318184038 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • signal transducer activity
    		•  3.24090483126624 bayes_pls_golite062009
  • cytokine binding
    		•  3.21238178184503 bayes_pls_golite062009
  • growth factor binding
    		•  2.99437744892471 bayes_pls_golite062009
  • cytokine receptor activity
    		•  2.76876397305497 bayes_pls_golite062009
  • binding
    		•  2.69537882298808 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  2.32179186005318 bayes_pls_golite062009
  • axon guidance receptor activity
    		•  2.01367445237355 bayes_pls_golite062009
  • peptide hormone binding
    		•  1.9205359237864 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.61421027298524 bayes_pls_golite062009
  • protein kinase activity
    		•  1.60674218431738 bayes_pls_golite062009
  • kinase activity
    		•  1.57994485110649 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44501485815273 bayes_pls_golite062009
  • receptor binding
    		•  1.31676259534833 bayes_pls_golite062009
  • hormone binding
    		•  1.31120662451488 bayes_pls_golite062009
  • interleukin-6 receptor activity
    		•  1.18385625326067 bayes_pls_golite062009
  • interleukin-6 binding
    		•  1.18385625326067 bayes_pls_golite062009
  • transferase activity
    		•  1.13635878582843 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.86564366658585 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.745125737480015 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.718355770608923 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.703490254739121 bayes_pls_golite062009
  • cell surface binding
    		•  0.694105914814106 bayes_pls_golite062009
  • kinase binding
    		•  0.65927255037265 bayes_pls_golite062009
  • DNA binding
    		•  0.609787884452433 bayes_pls_golite062009
  • ciliary neurotrophic factor receptor activity
    		•  0.60649323348068 bayes_pls_golite062009
  • enzyme binding
    		•  0.60195860585095 bayes_pls_golite062009
  • identical protein binding
    		•  0.564711394496051 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.554350228628563 bayes_pls_golite062009
  • peptide binding
    		•  0.47885601366674 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.46168925186147 bayes_pls_golite062009
  • protein kinase binding
    		•  0.405060010394646 bayes_pls_golite062009
  • interleukin-2 binding
    		•  0.240383688164201 bayes_pls_golite062009
  • SH2 domain binding
    		•  0.218079243436961 bayes_pls_golite062009
  • structural molecule activity
    		•  0.18965275490219 bayes_pls_golite062009
  • protein homodimerization activity
    		•  0.116391819218123 bayes_pls_golite062009
  • integrin binding
    		•  0.0873424694168858 bayes_pls_golite062009
  • polysaccharide binding
    		•  0.0807821124164596 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0148251912049181 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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