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View Structure Prediction Details

Protein: Ptp4E-PB
Organism: Drosophila melanogaster
Length: 1607 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ptp4E-PB.

Description E-value Query
Range		 Subject
Range
Ptp4E-PD, Ptp4E-... - The gene Protein tyrosine phosphatase 4E is referred to in FlyBase by the symbol Dmel\Ptp4E (CG6899,...
 1078.0 [0..1] [1606..1]

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Predicted Domain #1
Region A:
Residues: [1-521] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDCATRKQQQ LRAHHQQQQI QIQTHGRKRQ QLQKQRHNHH HYYQNSQQQQ KHFVWLVVGI  60
   61 LTIFLAQHAN AADLVINVPN ASSNANAFYR IDYSPPFGFP EPNTTIPASD IGKDIKFSRA 120
  121 LPGTEYNFWL YYTNSTHREQ LTWTVNITTA PDPPANLSVQ LRSSKSAFIT WRPPGSGRYS 180
  181 GFRIRVLGLT DLPFERSYSL EGNETLQLSA KELTPGGSYQ VQAYSVYQGK ESVAYTSRNF 240
  241 TTKPNTPGKF IVWFRNETTL LVLWQPPFPA GIYTHYRVSI TPDDAIQSVL YVEREGEPPG 300
  301 PAQAAFKGLV PGREYNISVQ TVSEDETSSV PTTARYLTVP ERVLNVTFDE AYTTSSSFRV 360
  361 RWEPPRTYSE FDAYQVMLST SRRIFNVPRA ANGDSVYFDY PDILEPGRTY EVVVKTIADN 420
  421 VNSWPASGEV TLRPRPVRSL GGFLDDRSNA LHISWEPAET GRQDSYRISY HEQTNASEVP 480
  481 APFPVAAESQ ITTNLTEYTL DSLLAGRRYL IAVQALSKGV A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.0
Match: 2v5yA
Description: No description for 2v5yA was found.

Predicted Domain #2
Region A:
Residues: [522-632] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNASDITRYT RPAAPLIQEL RSIDQGLMLS WRSDVNSRQD RYEVHYQRNG TREERTMATN  60
   61 ETSLTIHYLH PGSGYEVKVH AISHGVRSEP HSYFQAVFPK PPQNLTLQTV H

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 50.69897
Match: 1fnfA
Description: FRAGMENT OF HUMAN FIBRONECTIN ENCOMPASSING TYPE-III REPEATS 7 THROUGH 10
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [633-694] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TNLVVLHWQA PEGSDFSEYV VRYRTDASPW QRISGLHENE ARIKDMHYGE RYLVQVNTVS  60
   61 FG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 1x5gA
Description: The solution structure of the second fibronectin type III domain of human Neogenin
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [695-886] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VESPHPLELN VTMPPQPVSN VVPLVDSRNL TLEWPRPDGH VDFYTLKWWP TDEEDRVEFK  60
   61 NVTQLEDLSS PSVRIPIEDL SPGRQYRFEV QASSNGIRSG TTHLSTRTMP LIQSDVFIAN 120
  121 AGHEQGQDET ITLSYTPTPA DSTRFDIYRF SMGDPTIKDK EKLANDTERK LSFSGLTPGK 180
  181 LYNVTVWTVS GG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.0
Match: 1bp3B
Description: Prolactin receptor
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [887-989] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VASLPVQRLY RLHPLPISDL KAIQVAAREI TLHWTAPAGE YTDFELQYLS ADEEAPQLLQ  60
   61 NVTKNTEITL QGLRPYHNYT FTVVVRSGSI QGTDFADVSV STL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.045757
Match: 1fnhA
Description: Fibronectin, different Fn3 modules
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [990-1121] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRSSAPISAS YQTLTAPPGK VDYFQPSDVQ PGEVTFEWSL EPAEQHGPID YFRITCQNAD  60
   61 DAADVSSYEF PVNATQGKID GLVPGNHYIF RIQAKSALGY GAEREHIQTM PILAPPVPEP 120
  121 SVTPLEVSRT SS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 3.522879
Match: 2jixB
Description: No description for 2jixB was found.

Predicted functions:

Term Confidence Notes
transmembrane receptor activity 4.21125462030555 bayes_pls_golite062009
receptor activity 4.09185309744435 bayes_pls_golite062009
protein binding 3.24522318184038 bayes_pls_golite062009
molecular transducer activity 3.24090483126624 bayes_pls_golite062009
signal transducer activity 3.24090483126624 bayes_pls_golite062009
cytokine binding 3.21238178184503 bayes_pls_golite062009
growth factor binding 2.99437744892471 bayes_pls_golite062009
cytokine receptor activity 2.76876397305497 bayes_pls_golite062009
binding 2.69537882298808 bayes_pls_golite062009
cell adhesion molecule binding 2.32179186005318 bayes_pls_golite062009
axon guidance receptor activity 2.01367445237355 bayes_pls_golite062009
peptide hormone binding 1.9205359237864 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.61421027298524 bayes_pls_golite062009
protein kinase activity 1.60674218431738 bayes_pls_golite062009
kinase activity 1.57994485110649 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 1.44501485815273 bayes_pls_golite062009
receptor binding 1.31676259534833 bayes_pls_golite062009
hormone binding 1.31120662451488 bayes_pls_golite062009
interleukin-6 receptor activity 1.18385625326067 bayes_pls_golite062009
interleukin-6 binding 1.18385625326067 bayes_pls_golite062009
transferase activity 1.13635878582843 bayes_pls_golite062009
protein dimerization activity 0.86564366658585 bayes_pls_golite062009
nucleic acid binding 0.745125737480015 bayes_pls_golite062009
transcription regulator activity 0.718355770608923 bayes_pls_golite062009
protein serine/threonine kinase activity 0.703490254739121 bayes_pls_golite062009
cell surface binding 0.694105914814106 bayes_pls_golite062009
kinase binding 0.65927255037265 bayes_pls_golite062009
DNA binding 0.609787884452433 bayes_pls_golite062009
ciliary neurotrophic factor receptor activity 0.60649323348068 bayes_pls_golite062009
enzyme binding 0.60195860585095 bayes_pls_golite062009
identical protein binding 0.564711394496051 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.554350228628563 bayes_pls_golite062009
peptide binding 0.47885601366674 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.46168925186147 bayes_pls_golite062009
protein kinase binding 0.405060010394646 bayes_pls_golite062009
interleukin-2 binding 0.240383688164201 bayes_pls_golite062009
SH2 domain binding 0.218079243436961 bayes_pls_golite062009
structural molecule activity 0.18965275490219 bayes_pls_golite062009
protein homodimerization activity 0.116391819218123 bayes_pls_golite062009
integrin binding 0.0873424694168858 bayes_pls_golite062009
polysaccharide binding 0.0807821124164596 bayes_pls_golite062009
transcription factor activity 0.0148251912049181 bayes_pls_golite062009

Predicted Domain #7
Region A:
Residues: [1122-1280] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TIEISFRQGY FSNAHGMVRS YTIIIAEDVG KNASGLEMPS WQDVQAYTVW LPYQAIEPYN  60
   61 PFLTSNGSRK SSLEAEHFTI GTANCDKHQA GYCNGPLRAG TTYRIKIRAF TDEDKFTDTV 120
  121 YSSPITTERS DTVIVAATVS AVLLVAMVLV VVYCQHRCQ

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.13
Match: 2e7hA
Description: No description for 2e7hA was found.

Predicted Domain #8
Region A:
Residues: [1281-1607] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LIRRASKLAR MQDELAALPE GYITPNRPVH VKDFSEHYRI MSADSDFRFS EEFEELKHVG  60
   61 RDQACSFANL PCNRPKNRFT NILPYDHSRF KLQPVDDDDG SDYINANYMP GHNSPREFIV 120
  121 TQGPLHSTRE EFWRMCWESN SRAIVMLTRC FEKGREKCDQ YWPVDRVAMF YGDIKVQLII 180
  181 DTHYHDWSIS EFMVSRNCES RIMRHFHFTT WPDFGVPEPP QSLVRFVRAF RDVIGTDMRP 240
  241 IIVHCSAGVG RSGTFIALDR ILQHIHKSDY VDIFGIVFAM RKERVFMVQT EQQYVCIHQC 300
  301 LLAVLEGKEH LLADSLELHA NDGYEVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 94.154902
Match: 2gjtA
Description: No description for 2gjtA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle