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Protein Overview: FBpp0310135, Pp2...

General Information:
Name(s) found: FBpp0310135 [FlyBase]
Pp2C1-PA / FBpp0070653 [FlyBase]
Description(s) found:
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  • gi|24639731|ref|NP_525074.2| protein phosphatase 2C [Drosophila melanogaster] [NCBI NR]
  • gi|22831696|gb|AAF45974.2| protein phosphatase 2C [Drosophila melanogaster] [NCBI NR]
  • gi|17862522|gb|AAL39738.1| LD34192p [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=X:complement(4574665..4577455,4577520..4577967,4579145..4580189); ID=FBpp0310135; name=Pp2C1-PB; parent=FBgn0022768,FBtr0343531; dbxref=FlyBase:FBpp0310135,FlyBase_Annotation_IDs:CG2984-PB; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r5.56; species=Dmel; [FlyBase]
  • The gene Protein phosphatase 2C is referred to in FlyBase by the symbol Dmel\Pp2C1 (CG2984, FBgn0022768). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4574433..4580904. It has the cytological map location 4C12-4C13. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine phosphatase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: protein amino acid dephosphorylation. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG2984-PA translation from_gene[CG2984 Pp2C1 FBgn0022768] seq_release:3 mol_weight=153907 cds_boundaries:(X:4,421,248..4,426,769[-]) aa_length:1427 transcript_info:[CG2984-RA seq_release:3] gene_info:[gene symbol:Pp2C1 FBgn0022768 gene_boundaries:(X:4 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W4H8) CG2984 protein (LD34192p) [DrosMelano7227.FASTAC.txt]
  • CG2984-PA [Drosophila melanogaster]gi|17862522|gb|AAL39738.1| LD34192p [Drosophila melanogaster]gi|24639731|ref|NP_525074.2| CG2984-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(4574665..4577455,4577520..4577967,4579145..4580189); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protei [fly-100309-contam.fasta]
  • CG2984-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD34192p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Protein phosphatase 2C CG2984-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(4574665..4577455,4577520..4577967,4579145..4580189); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(4574665..4577455,4577520..4577967,4579145..4580189); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • LD34192p OS=Drosophila melanogaster GN=Pp2C1 PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(4574665..4577455,4577520..4577967,4579145..4580189); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974,FlyMine:FBpp0070653,modMine:FBpp0070653; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • LD34192p OS=Drosophila melanogaster GN=Pp2C1 PE=2 SV=2 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974,FlyMine:FBpp0070653,modMine:FBpp0070653; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0310135; name=Pp2C1-PB; parent=FBgn0022768,FBtr0343531; dbxref=GB_protein:AHN59338,REFSEQ:NP_001284867,FlyBase:FBpp0310135,FlyBase_Annotation_IDs:CG2984-PB; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974,FlyMine:FBpp0070653,modMine:FBpp0070653; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0310135; name=Pp2C1-PB; parent=FBgn0022768,FBtr0343531; dbxref=GB_protein:AHN59338,REFSEQ:NP_001284867,FlyBase:FBpp0310135,FlyBase_Annotation_IDs:CG2984-PB; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0070653 type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974,FlyMine:FBpp0070653,modMine:FBpp0070653; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • FBpp0310135 type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0310135; name=Pp2C1-PB; parent=FBgn0022768,FBtr0343531; dbxref=GB_protein:AHN59338,REFSEQ:NP_001284867,FlyBase:FBpp0310135,FlyBase_Annotation_IDs:CG2984-PB; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0070653; name=Pp2C1-PA; parent=FBgn0022768,FBtr0070685; dbxref=FlyBase:FBpp0070653,FlyBase_Annotation_IDs:CG2984-PA,GB_protein:AAF45974.2,REFSEQ:NP_525074,GB_protein:AAF45974,UniProt/TrEMBL:Q9W4H8,FlyMine:FBpp0070653,modMine:FBpp0070653; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
  • type=protein; loc=X:complement(join(4685112..4686156,4683487..4683934,4680632..4683422)); ID=FBpp0310135; name=Pp2C1-PB; parent=FBgn0022768,FBtr0343531; dbxref=GB_protein:AHN59338,REFSEQ:NP_001284867,FlyBase:FBpp0310135,FlyBase_Annotation_IDs:CG2984-PB,UniProt/TrEMBL:Q9W4H8; MD5=6983db581214528d8416bb3d5e309306; length=1427; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1427 amino acids

    Gene Ontology:
    Cellular Component: protein serine/threonine phosphatase complex [IEA]
    Biological Process: protein amino acid dephosphorylation [IEA][ISS][NAS]
    oxidation reduction [IEA]
    Molecular Function: protein serine/threonine phosphatase activity [IEA][ISS][NAS]
    oxidoreductase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPANNRSST STHTNTNANT INATTNTTNR CLINTAIEKT VVRLRETAAN SGTFQDSDES  60
   61 SVEFDIINYY GDDGGTTPAP APATASVTRH GGSSSGNNNN NSACHPALDA SSDVVVVEPA 120
  121 AVGVAQEEEE EPEQRPERIS IPIPDLAFTE MEAYAEDIVV DMEGGSPAKP LNPKKQRLNS 180
  181 ATTTTINRSR GGGAAQSRLR RSAAIVPPRS IPESCASSSN SNSSSSSNSN SSSSSATGSS 240
  241 ASTGNPSPCS SLGVNMRVTG QCCQGGRKYM EDQFSVAYQE SPITHELEYA FFGIYDGHGG 300
  301 PEAALFAKEH LMLEIVKQKQ FWSDQDEDVL RAIREGYIAT HFAMWREQEK WPRTANGHLS 360
  361 TAGTTATVAF MRREKIYIGH VGDSGIVLGY QNKGERNWRA RPLTTDHKPE SLAEKTRIQR 420
  421 SGGNVAIKSG VPRVVWNRPR DPMHRGPIRR RTLVDEIPFL AVARSLGDLW SYNSRFKEFV 480
  481 VSPDPDVKVV KINPSTFRCL IFGTDGLWNV VTAQEAVDSV RKEHLIGEIL NEQDVMNPSK 540
  541 ALVDQALKTW AAKKMRADNT SVVTVILTPA ARNNSPTTPT RSPSAMARDN DLEVELLLEE 600
  601 DDEELPTLDV ENNYPDFLIE EHEYVLDQPY SALAKRHSPP EAFRNFDYFD VDEDELDEDE 660
  661 ETVEEDEEEE EEEEETKSVG ILQQSLFNPR KTWRKSTINN SWSGVTEPEP EPDPEPDRID 720
  721 VLTLDMYSHT SIDKGTNYGG SIAQSSIDPA ETAENRELSE LEQHLESSYS FAESYNSLLN 780
  781 EQEEQEARSR SAAAAAAAAE AAAVEAQQTT AHSASVVLDR SMLEIIQEQQ HYQQQEGYSL 840
  841 TQLETRRERE RLTESWPQQP AELLELDALL QQERAEEEQV ALEQQQQREQ QMEQMEVEAI 900
  901 SSSGQHEFAY PVTTATASEW CATLQEDEEE LDSTVIDIVI QPEQELQDNE VSSTLPATPT 960
  961 HVEPEQIVDK MEPLKVQEML TAVEKPPSKQ EKKLPKKQET KQVAVLDTVA EMPKEDAHAV1020
 1021 HYIFQRIQKV QDSEATPVAV TNSTMADALP TESSGLGGSM TAPRIRRYRN VPNENHQHMQ1080
 1081 TRRRQIFKHV KPKSFIQSSA AAIVAYGDST ETVGGTAGAS GTPAAGRVGG GGGGGGGRGS1140
 1141 ASGGSSPAVA ANSRRSVNVV ANASGNSASK VVPSSSSMMM TRRSHTLTAS GGVNKRQLRS1200
 1201 SLCTLGLGVG VGVGLGMDLD MTKRTLRTRN VPALSGGSAT PSSNSSPASG GSSPAGFTSP1260
 1261 ASPVITSRGS GSRTTASPAR RLKRSHEDRE QRMSLRRSTL SGSASGSGLV GTGGSPSNVK1320
 1321 SNRLQACNGA ISARPPPSPK KLNAAVPTLA IGTRAYTAAL AAAADHLNKR WSLRSSSGNS1380
 1381 GNLITAISCY SDRSRAATAA GSPGSGGGAA GPPGASLAAS TVGTRRR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] deduced N/A No confident structure predictions are available.
    2 View Details [230..474] PSI-BLAST 78.69897 CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION
    3 View Details [475..645] FFAS03 3.79 CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION
    4 View Details [646..1013] PSI-BLAST 31.221849 Heavy meromyosin subfragment
    5 View Details [1014..1141] deduced N/A No confident structure predictions are available.
    6 View Details [1142..1427] PSI-BLAST 6.0 DELETION MUTANT DELTA(145-150), F151D OF CYCLODEXTRIN GLYCOSYLTRANSFERASE

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  7.29765002420868 bayes_pls_golite062009
  • phosphatase activity
    		•  6.84540130415879 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  6.63839066304808 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  6.20846750257603 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  5.76293366458633 bayes_pls_golite062009
  • hydrolase activity
    		•  4.47529953910458 bayes_pls_golite062009
  • binding
    		•  1.74689317666387 bayes_pls_golite062009
  • signal transducer activity
    		•  1.61688496161233 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.61688496161233 bayes_pls_golite062009
  • catalytic activity
    		•  1.53401212718168 bayes_pls_golite062009
  • protein binding
    		•  1.47578617076714 bayes_pls_golite062009
    3
    Term Confidence Notes
  • phosphoprotein phosphatase activity
    		•  4.71424862922036 bayes_pls_golite062009
  • phosphatase activity
    		•  4.28976995079138 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  4.12210528306749 bayes_pls_golite062009
  • protein serine/threonine phosphatase activity
    		•  3.58694950037681 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  3.3583656941248 bayes_pls_golite062009
  • hydrolase activity
    		•  2.79325127936186 bayes_pls_golite062009
  • signal transducer activity
    		•  2.67101177291813 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.67101177291813 bayes_pls_golite062009
  • binding
    		•  2.23778052962551 bayes_pls_golite062009
  • protein binding
    		•  1.88313140430815 bayes_pls_golite062009
  • catalytic activity
    		•  0.585392957294978 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.0722225423987746 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • cation channel activity
    		•  6.88240085289131 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  6.77858282231856 bayes_pls_golite062009
  • ion channel activity
    		•  6.735767701291 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  6.68495077480596 bayes_pls_golite062009
  • channel activity
    		•  6.68495077480596 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  6.66696356327879 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  6.65066046775891 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  6.62672508361936 bayes_pls_golite062009
  • gated channel activity
    		•  6.5977766850024 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.43910566380706 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  6.386919461526 bayes_pls_golite062009
  • potassium channel activity
    		•  6.32219445062001 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  5.23909234996547 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  5.23909234996547 bayes_pls_golite062009
  • binding
    		•  2.65544526722793 bayes_pls_golite062009
  • protein binding
    		•  2.55331587515144 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.40822298338589 bayes_pls_golite062009
  • inward rectifier potassium channel activity
    		•  2.27358792549403 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.08187588169534 bayes_pls_golite062009
  • hydrolase activity
    		•  2.06919456358346 bayes_pls_golite062009
  • transporter activity
    		•  2.05709417400762 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.05612183773834 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.0182817049046 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.00656939031268 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.0001113584937 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.97130850809528 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.58137213443919 bayes_pls_golite062009
  • signal transducer activity
    		•  1.58137213443919 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.55727555528218 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.44225801859996 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.42486878565247 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.05880190577068 bayes_pls_golite062009
  • kinase activity
    		•  0.947913186714015 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.941073705584189 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.836127462661489 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.71818218589805 bayes_pls_golite062009
  • actin binding
    		•  0.68323011536902 bayes_pls_golite062009
  • protein kinase activity
    		•  0.672303480615463 bayes_pls_golite062009
  • opsin binding
    		•  0.62444824201719 bayes_pls_golite062009
  • GDP-dissociation inhibitor activity
    		•  0.580608094701522 bayes_pls_golite062009
  • kinase binding
    		•  0.436626396925482 bayes_pls_golite062009
  • protein kinase binding
    		•  0.431763794621332 bayes_pls_golite062009
  • Rho GDP-dissociation inhibitor activity
    		•  0.423399573549555 bayes_pls_golite062009
  • enzyme binding
    		•  0.37496592438035 bayes_pls_golite062009
  • transferase activity
    		•  0.245545083443102 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.188120291726544 bayes_pls_golite062009
  • actin filament binding
    		•  0.174117588261881 bayes_pls_golite062009
  • steroid binding
    		•  0.107788328417256 bayes_pls_golite062009
  • metarhodopsin binding
    		•  0.0235351884448112 bayes_pls_golite062009
  • receptor binding
    		•  0.023071936893736 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.64

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle