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Protein Overview: FBpp0310174, mei...

General Information:
Name(s) found: FBpp0310174 [FlyBase]
mei-9-PA / FBpp0070624 [FlyBase]
Description(s) found:
Found 29 descriptions.
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  • type=protein; loc=X:complement(4208885..4209826,4209893..4210719,4210782..4210936,4210997..4211593,4211666..4211827,4211886..4212088); ID=FBpp0310174; name=mei-9-PB; parent=FBgn0002707,FBtr0343574; dbxref=FlyBase:FBpp0310174,FlyBase_Annotation_IDs:CG3697-PB; MD5=b95ddc7b057f545adeabc17dbe660ec0; length=961; release=r5.56; species=Dmel; [FlyBase]
  • The gene meiotic 9 is referred to in FlyBase by the symbol Dmel\mei-9 (CG3697, FBgn0002707). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4208263..4212834. It has the cytological map location 4B6. There is experimental evidence that it has the molecular function</span>: protein binding; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process</span>: meiotic chromosome segregation; female meiosis chromosome segregation; reciprocal meiotic recombination; mismatch repair; resolution of meiotic recombination intermediates; nucleotide-excision repair. 25 alleles are reported. The phenotypes of these alleles are annotated with: presumptive oocyte; egg chamber. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 961 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    protein complex [IDA]
    Biological Process: reciprocal meiotic recombination [IMP]
    meiotic chromosome segregation [IMP]
    DNA recombination [NAS][TAS]
    nucleotide-excision repair [IMP][ISS][NAS][TAS]
    resolution of meiotic recombination intermediates [IMP][TAS]
    female meiosis chromosome segregation [IMP]
    mismatch repair [IMP][NAS]
    DNA metabolic process [IEA]
    double-strand break repair [TAS]
    Molecular Function: DNA binding [IEA]
    protein binding [IPI]
    protein heterodimerization activity [IPI]
    endodeoxyribonuclease activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADSCAENAA KGTENERPKE VEASADTVPQ VEEGVEEYLK RKNMVLLDYE KQMFLDLVEA  60
   61 DGLLVCAKGL SYDRVVISIL KAYSDSGNLV LVINSSDWEE QYYKSKIEPK YVHEVASTAT 120
  121 ERERVYLEGG LQFISTRILV VDLLKQRIPI ELISGIIVLR AHTIIESCQE AFALRLFRQK 180
  181 NKTGFVKAFS SSPEAFTIGY SHVERTMRNL FVKHLYIWPR FHESVRTVLQ PWKIQSIEMH 240
  241 VPISQNITSI QSHILEIMNF LVQEIKRINR TVDMEAVTVE NCVTKSFHKI LQAQLDCIWH 300
  301 QLNSQTKLIV ADLKILRSLM ISTMYHDAVS AYAFMKRYRS TEYALSNSGW TLLDAAEQIF 360
  361 KLSRQRVFNG QQEFEPEPCP KWQTLTDLLT KEIPGDMRRS RRSEQQPKVL ILCQDARTCH 420
  421 QLKQYLTQGG PRFLLQQALQ HEVPVGKLSD NYAKESQTRS APPKNVSSNK ELRREEVSGS 480
  481 QPPLAGMDEL AQLLSESETE GQHFEESYML TMTQPVEVGP AAIDIKPDPD VSIFETIPEL 540
  541 EQFDVTAALA SVPHQPYICL QTFKTEREGS MALEHMLEQL QPHYVVMYNM NVTAIRQLEV 600
  601 FEARRRLPPA DRMKVYFLIH ARTVEEQAYL TSLRREKAAF EFIIDTKSKM VIPKYQDGKT 660
  661 DEAFLLLKTY DDEPTDENAK SRQAGGQAPQ ATKETPKVIV DMREFRSDLP CLIHKRGLEV 720
  721 LPLTITIGDY ILTPDICVER KSISDLIGSL NSGRLYNQCV QMQRHYAKPI LLIEFDQNKP 780
  781 FHLQGKFMLS QQTSMANADI VQKLQLLTLH FPKLRLIWSP SPYATAQLFE ELKLGKPEPD 840
  841 PQTAAALGSD EPTAGEQLHF NSGIYDFLLR LPGVHTRNIH GLLRKGGSLR QLLLRSQKEL 900
  901 EELLQSQESA KLLYDILHVA HLPEKDEVTG STALLAASKQ FGAGSHNRFR MAAAASRRGR 960
  961 R

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..602] PSI-BLAST 64.522879 Crystal structure of Pyrococcus furiosus Hef helicase domain
    2 View Details [603..670] deduced N/A No confident structure predictions are available.
    3 View Details [671..961] PSI-BLAST 28.0 XPF from Aeropyrum pernix, complex with DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  12.5797089932289 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  7.65460057398582 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  6.8949486660401 bayes_pls_golite062009
  • endonuclease activity
    		•  6.81743235298471 bayes_pls_golite062009
  • four-way junction helicase activity
    		•  4.48421726286311 bayes_pls_golite062009
  • DNA helicase activity
    		•  4.45575761476577 bayes_pls_golite062009
  • DNA strand annealing activity
    		•  3.51692202399009 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  3.48615352002265 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  3.44605832131927 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  3.37084035853131 bayes_pls_golite062009
  • damaged DNA binding
    		•  2.98078816242626 bayes_pls_golite062009
  • DNA binding
    		•  2.97855002479178 bayes_pls_golite062009
  • helicase activity
    		•  2.83648239124034 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.79236389919005 bayes_pls_golite062009
  • nuclease activity
    		•  2.20113675721212 bayes_pls_golite062009
  • binding
    		•  2.17324322139334 bayes_pls_golite062009
  • hydrolase activity
    		•  2.07039693890326 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.69645042781713 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  1.26255690081743 bayes_pls_golite062009
  • transposase activity
    		•  1.10140160488189 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.05548921907953 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.02983374615445 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.01049916010827 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.00920723797259 bayes_pls_golite062009
  • catalytic activity
    		•  0.816447099398022 bayes_pls_golite062009
  • protein binding
    		•  0.71091195096997 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle