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View Structure Prediction Details

Protein: FBpp0310174, mei...
Organism: Drosophila melanogaster
Length: 961 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0310174, mei....

Description E-value Query
Range
Subject
Range
gi|25009805 - gi|25009805|gb|AAN71074.1| AT15210p [Drosophila melanogaster]
601.0 [0..1] [947..1]

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Predicted Domain #1
Region A:
Residues: [1-602]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADSCAENAA KGTENERPKE VEASADTVPQ VEEGVEEYLK RKNMVLLDYE KQMFLDLVEA  60
   61 DGLLVCAKGL SYDRVVISIL KAYSDSGNLV LVINSSDWEE QYYKSKIEPK YVHEVASTAT 120
  121 ERERVYLEGG LQFISTRILV VDLLKQRIPI ELISGIIVLR AHTIIESCQE AFALRLFRQK 180
  181 NKTGFVKAFS SSPEAFTIGY SHVERTMRNL FVKHLYIWPR FHESVRTVLQ PWKIQSIEMH 240
  241 VPISQNITSI QSHILEIMNF LVQEIKRINR TVDMEAVTVE NCVTKSFHKI LQAQLDCIWH 300
  301 QLNSQTKLIV ADLKILRSLM ISTMYHDAVS AYAFMKRYRS TEYALSNSGW TLLDAAEQIF 360
  361 KLSRQRVFNG QQEFEPEPCP KWQTLTDLLT KEIPGDMRRS RRSEQQPKVL ILCQDARTCH 420
  421 QLKQYLTQGG PRFLLQQALQ HEVPVGKLSD NYAKESQTRS APPKNVSSNK ELRREEVSGS 480
  481 QPPLAGMDEL AQLLSESETE GQHFEESYML TMTQPVEVGP AAIDIKPDPD VSIFETIPEL 540
  541 EQFDVTAALA SVPHQPYICL QTFKTEREGS MALEHMLEQL QPHYVVMYNM NVTAIRQLEV 600
  601 FE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.522879
Match: 1wp9A
Description: Crystal structure of Pyrococcus furiosus Hef helicase domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [603-670]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARRRLPPADR MKVYFLIHAR TVEEQAYLTS LRREKAAFEF IIDTKSKMVI PKYQDGKTDE  60
   61 AFLLLKTY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [671-961]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DDEPTDENAK SRQAGGQAPQ ATKETPKVIV DMREFRSDLP CLIHKRGLEV LPLTITIGDY  60
   61 ILTPDICVER KSISDLIGSL NSGRLYNQCV QMQRHYAKPI LLIEFDQNKP FHLQGKFMLS 120
  121 QQTSMANADI VQKLQLLTLH FPKLRLIWSP SPYATAQLFE ELKLGKPEPD PQTAAALGSD 180
  181 EPTAGEQLHF NSGIYDFLLR LPGVHTRNIH GLLRKGGSLR QLLLRSQKEL EELLQSQESA 240
  241 KLLYDILHVA HLPEKDEVTG STALLAASKQ FGAGSHNRFR MAAAASRRGR R

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.0
Match: 2bgwA
Description: XPF from Aeropyrum pernix, complex with DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
single-stranded DNA specific endodeoxyribonuclease activity 12.5797089932289 bayes_pls_golite062009
endodeoxyribonuclease activity 7.65460057398582 bayes_pls_golite062009
deoxyribonuclease activity 6.8949486660401 bayes_pls_golite062009
endonuclease activity 6.81743235298471 bayes_pls_golite062009
four-way junction helicase activity 4.48421726286311 bayes_pls_golite062009
DNA helicase activity 4.45575761476577 bayes_pls_golite062009
DNA strand annealing activity 3.51692202399009 bayes_pls_golite062009
excinuclease ABC activity 3.48615352002265 bayes_pls_golite062009
single-stranded DNA binding 3.44605832131927 bayes_pls_golite062009
structure-specific DNA binding 3.37084035853131 bayes_pls_golite062009
damaged DNA binding 2.98078816242626 bayes_pls_golite062009
DNA binding 2.97855002479178 bayes_pls_golite062009
helicase activity 2.83648239124034 bayes_pls_golite062009
nucleic acid binding 2.79236389919005 bayes_pls_golite062009
nuclease activity 2.20113675721212 bayes_pls_golite062009
binding 2.17324322139334 bayes_pls_golite062009
hydrolase activity 2.07039693890326 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.69645042781713 bayes_pls_golite062009
double-stranded DNA binding 1.26255690081743 bayes_pls_golite062009
transposase activity 1.10140160488189 bayes_pls_golite062009
nucleoside-triphosphatase activity 1.05548921907953 bayes_pls_golite062009
pyrophosphatase activity 1.02983374615445 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 1.01049916010827 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 1.00920723797259 bayes_pls_golite062009
catalytic activity 0.816447099398022 bayes_pls_golite062009
protein binding 0.71091195096997 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle