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Protein Overview: FBpp0303995, dm-PA

General Information:
Name(s) found: FBpp0303995 [FlyBase]
dm-PA / FBpp0070501 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • type=protein; loc=X:join(3269039..3270266,3278420..3279345); ID=FBpp0303995; name=dm-PB; parent=FBgn0262656,FBtr0331605; dbxref=REFSEQ:NP_001259204,GB_protein:AGB95050,FlyBase:FBpp0303995,FlyBase_Annotation_IDs:CG10798-PB; MD5=e44e63f0cfcacca7bbfbbd1cf00497ce; length=717; release=r5.56; species=Dmel; [FlyBase]
  • The gene diminutive is referred to in FlyBase by the symbol Dmel\dm (CG10798, FBgn0000472). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3267216..3280049. It has the cytological map location 3D2. There is experimental evidence that it has the molecular function</span>: transcription factor activity; protein binding; DNA binding. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: regulation of biological process; regulation of metabolic process; multicellular organismal development; regulation of growth; embryonic development; cell proliferation; embryonic development ending in birth or egg hatching; cell cycle; regulation of apoptosis; positive regulation of cellular biosynthetic process; anatomical structure development; cellular process; embryonic pattern specification; negative regulation of Notch signaling pathway. 54 alleles are reported. The phenotypes of these alleles are annotated with 26 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; external compound sense organ; female germline cyst; cell cycle; nucleus; thoracic segment; imaginal precursor; intracellular membrane-bounded organelle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 717 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    protein complex [IPI]
    Biological Process: cell proliferation [IEP]
    positive regulation of growth [TAS]
    cell competition in a multicellular organism [IMP]
    embryonic development ending in birth or egg hatching [IEP]
    embryonic pattern specification [IGI]
    regulation of cell size [TAS]
    regulation of transcription, DNA-dependent [IDA]
    DNA endoreduplication [IMP]
    positive regulation of transcription [IMP]
    regulation of organ growth [IMP]
    neurogenesis [IGI]
    regulation of apoptosis [IMP]
    regulation of transcription [IEA][IMP]
    negative regulation of Notch signaling pathway [IGI]
    positive regulation of multicellular organism growth [TAS]
    cellular process [IMP]
    positive regulation of cell growth [TAS]
    oogenesis [TAS]
    regulation of cell growth [IMP]
    regulation of cell cycle [TAS]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [IDA][ISS]
    protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALYRSDPYS IMDDQLFSNI SIFDMDNDLY DMDKLLSSST IQSDLEKIED MESVFQDYDL  60
   61 EEDMKPEIRN IDCMWPAMSS CLTSGNGNGI ESGNSAASSY SETGAVSLAM VSGSTNLYSA 120
  121 YQRSQTTDNT QSNQQHVVNS AENMPVIIKK ELADLDYTVC QKRLRLSGGD KKSQIQDEVH 180
  181 LIPPGGSLLR KRNNQDIIRK SGELSGSDSI KYQRPDTPHS LTDEVAASEF RHNVDLRACV 240
  241 MGSNNISLTG NDSDVNYIKQ ISRELQNTGK DPLPVRYIPP INDVLDVLNQ HSNSTGGQQQ 300
  301 LNQQQLDEQQ QAIDIATGRN TVDSPPTTGS DSDSDDGEPL NFDLRHHRTS KSGSNASITT 360
  361 NNNNSNNKNN KLKNNSNGML HMMHITDHSY TRCNDMVDDG PNLETPSDSD EEIDVVSYTD 420
  421 KKLPTNPSCH LMGALQFQMA HKISIDHMKQ KPRYNNFNLP YTPASSSPVK SVANSRYPSP 480
  481 SSTPYQNCSS ASPSYSPLSV DSSNVSSSSS SSSSQSSFTT SSSNKGRKRS SLKDPGLLIS 540
  541 SSSVYLPGVN NKVTHSSMMS KKSRGKKVVG TSSGNTSPIS SGQDVDAMDR NWQRRSGGIA 600
  601 TSTSSNSSVH RKDFVLGFDE ADTIEKRNQH NDMERQRRIG LKNLFEALKK QIPTIRDKER 660
  661 APKVNILREA AKLCIQLTQE EKELSMQRQL LSLQLKQRQD TLASYQMELN ESRSVSG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..191] deduced N/A No confident structure predictions are available.
    2 View Details [192..324] PSI-BLAST 12.522879 No description for 2ii0A was found.
    3 View Details [325..508] MSA 7.312994 View MSA. No confident structure predictions are available.
    4 View Details [509..587] deduced N/A No confident structure predictions are available.
    5 View Details [588..717] PSI-BLAST 23.154902 Myc prot-oncogene protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • transcription activator activity
    		•  3.87875547821718 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.42035985454056 bayes_pls_golite062009
  • protein binding
    		•  2.64975291677725 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.48787404513864 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.44519817693888 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.07771706364343 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • promoter binding
    		•  0.94414084000081 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.93846047598021 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.53175615551166 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.20674648626116 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle