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Protein Overview: dnc-PN

General Information:
Name(s) found: dnc-PN / FBpp0070495 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 983 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nonassociative learning [TAS]
    signal transduction [IEA]
    cyclic nucleotide metabolic process [NAS]
    synaptic transmission [IMP]
    olfactory learning [TAS]
    behavioral response to ethanol [NAS]
    learning [NAS]
    circadian rhythm [TAS]
    associative learning [TAS]
    memory [TAS]
    behavior [TAS]
    reproduction [NAS]
    conditioned taste aversion [IMP]
    learning or memory [NAS][TAS]
    mating behavior [TAS]
    short-term memory [IMP]
    oogenesis [TAS]
    locomotor rhythm [NAS]
    axon extension [IMP]
    courtship behavior [TAS]
    cAMP-mediated signaling [NAS]
    Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity [ISS][TAS]
    3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIATLFIIFA FIRAFPWSRK RGRPALALTL MPEGGEDHRG DLNQKGENNN RPRPSISLAN  60
   61 NGEAMAPRTR RKSSKFHEVT FSGSVGGGDS DGGGEAINGG NLDVSPSKRH SLSTTTSNSS 120
  121 SAPYRYLSGS SRSRGSRGDC HEYYQLQQHS SSLSNGNRGN RGLSQRSDTM ATEAEGEEFD 180
  181 VDPMDEDDED QTYDRETEEF YSNIQDAAGT GSSSRSKRSS LFSRSDSSAT TTSSSGGGTF 240
  241 TGGKRRSAAS ILSSSMCSDL MTSDRRSSTA TEYSVKSVTT GNTSQRRSSG RIRRYVSRMT 300
  301 IAGARRRTTG SFDVENGQGA RSPLEGGSPS AGLVLQNLPQ RRESFLYRSD SDFEMSPKSM 360
  361 SRNSSIASES HGEDLIVTPF AQILASLRSV RNNLLSLTNV PASNKSRRPN QSSSASRSGN 420
  421 PPGAPLSQGE EAYTRLATDT IEELDWCLDQ LETIQTHRSV SDMASLKFKR MLNKELSHFS 480
  481 ESSRSGNQIS EYICSTFLDK QQEFDLPSLR VEDNPELVAA NAAAGQQSAG QYARSRSPRG 540
  541 PPMSQISGVK RPLSHTNSFT GERLPTFGVE TPRENELGTL LGELDTWGIQ IFSIGEFSVN 600
  601 RPLTCVAYTI FQSRELLTSL MIPPKTFLNF MSTLEDHYVK DNPFHNSLHA ADVTQSTNVL 660
  661 LNTPALEGVF TPLEVGGALF AACIHDVDHP GLTNQFLVNS SSELALMYND ESVLENHHLA 720
  721 VAFKLLQNQG CDIFCNMQKK QRQTLRKMVI DIVLSTDMSK HMSLLADLKT MVETKKVAGS 780
  781 GVLLLDNYTD RIQVLENLVH CADLSNPTKP LPLYKRWVAL LMEEFFLQGD KERESGMDIS 840
  841 PMCDRHNATI EKSQVGFIDY IVHPLWETWA DLVHPDAQDI LDTLEENRDY YQSMIPPSPP 900
  901 PSGVDENPQE DRIRFQVTLE ESDQENLAEL EEGDESGGES TTTGTTGTTA ASALSGAGGG 960
  961 GGGGGGMAPR TGGCQNQPQH GGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..182] deduced N/A No confident structure predictions are available.
    2 View Details [183..430] MSA 7.140997 View MSA. No confident structure predictions are available.
    3 View Details [431..558] MSA 1.219989 View MSA. No confident structure predictions are available.
    4 View Details [559..983] PSI-BLAST 141.0 No description for 2fm0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  3.86434485322172 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  3.8566356686502 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.16734214417311 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  2.29938697204184 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.29281173183086 bayes_pls_golite062009
  • catalytic activity
    		•  1.44092158711463 bayes_pls_golite062009
  • hydrolase activity
    		•  1.06080266556153 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.815214868148798 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.196287846714023 bayes_pls_golite062009
  • binding
    		•  0.0840884387362641 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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