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Protein Overview: dnc-PM

General Information:
Name(s) found: dnc-PM / FBpp0070492 [FlyBase]
Description(s) found:
Found 15 descriptions.
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  • The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3070475..3233360. It has the cytological map location 3C9-3D1. Based on sequence similarity, it is predicted to have molecular function</span>: 3',5'-cyclic-AMP phosphodiesterase activity. There is experimental evidence that it is involved in the biological process</span>: synaptic transmission; conditioned taste aversion; short-term memory; axon extension. 72 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: anatomical structure; organ system; embryonic neuron; embryonic nervous system; female germline cyst; nervous system; developing anatomical structure; egg; multi-cell-component structure; synapse; postsynaptic membrane; adult brain; neuromuscular junction. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 903 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: nonassociative learning [TAS]
    signal transduction [IEA]
    cyclic nucleotide metabolic process [NAS]
    synaptic transmission [IMP]
    olfactory learning [TAS]
    behavioral response to ethanol [NAS]
    learning [NAS]
    circadian rhythm [TAS]
    associative learning [TAS]
    memory [TAS]
    behavior [TAS]
    reproduction [NAS]
    conditioned taste aversion [IMP]
    learning or memory [NAS][TAS]
    mating behavior [TAS]
    short-term memory [IMP]
    oogenesis [TAS]
    locomotor rhythm [NAS]
    axon extension [IMP]
    courtship behavior [TAS]
    cAMP-mediated signaling [NAS]
    Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity [ISS][TAS]
    3',5'-cyclic-nucleotide phosphodiesterase activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPPRRRRTA VAASAAAAAA ATTTTTTTTA TRAATTTPVT TAPTPTAITT TYRSRNLLKA  60
   61 TAKVKKKKKW KQISFVDDQQ RLKQAATSAE RKRSTSSAPP ALESNVPPRL GRFLRQKSSE 120
  121 TNSAATSAAA AAVQTEAETG RRKSSAASII AAAAGAAGLH NNNSSSCAAT ASEEQNSSGT 180
  181 LTGSSGNTST STWCGSINFL VYMVCSFCCC CYNFRNSPFD VENGQGARSP LEGGSPSAGL 240
  241 VLQNLPQRRE SFLYRSDSDF EMSPKSMSRN SSIASERFKE QEASILVDRS HGEDLIVTPF 300
  301 AQILASLRSV RNNLLSLTNV PASNKSRRPN QSSSASRSGN PPGAPLSQGE EAYTRLATDT 360
  361 IEELDWCLDQ LETIQTHRSV SDMASLKFKR MLNKELSHFS ESSRSGNQIS EYICSTFLDK 420
  421 QQEFDLPSLR VEDNPELVAA NAAAGQQSAG QYARSRSPRG PPMSQISGVK RPLSHTNSFT 480
  481 GERLPTFGVE TPRENELGTL LGELDTWGIQ IFSIGEFSVN RPLTCVAYTI FQSRELLTSL 540
  541 MIPPKTFLNF MSTLEDHYVK DNPFHNSLHA ADVTQSTNVL LNTPALEGVF TPLEVGGALF 600
  601 AACIHDVDHP GLTNQFLVNS SSELALMYND ESVLENHHLA VAFKLLQNQG CDIFCNMQKK 660
  661 QRQTLRKMVI DIVLSTDMSK HMSLLADLKT MVETKKVAGS GVLLLDNYTD RIQVLENLVH 720
  721 CADLSNPTKP LPLYKRWVAL LMEEFFLQGD KERESGMDIS PMCDRHNATI EKSQVGFIDY 780
  781 IVHPLWETWA DLVHPDAQDI LDTLEENRDY YQSMIPPSPP PSGVDENPQE DRIRFQVTLE 840
  841 ESDQENLAEL EEGDESGGES TTTGTTGTTA ASALSGAGGG GGGGGGMAPR TGGCQNQPQH 900
  901 GGM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..215] FFAS03 1.06 Crystal Structure of the oxy-form of the copper-bound Streptomyces castaneoglobisporus tyrosinase complexed with a caddie protein prepared by the addition of hydrogenperoxide
    2 View Details [216..347] deduced N/A No confident structure predictions are available.
    3 View Details [348..470] deduced N/A No confident structure predictions are available.
    4 View Details [471..903] PSI-BLAST 141.0 No description for 2fm0A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  4.70762025272187 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.66767157264894 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  4.40961779134517 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  3.68838886134169 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.64567538445993 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.26293733853576 bayes_pls_golite062009
  • hydrolase activity
    		•  1.17086565360856 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • binding
    		•  0.994379083280533 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.893957699588543 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009
    4
    Term Confidence Notes
  • cyclic-nucleotide phosphodiesterase activity
    		•  4.70762025272187 bayes_pls_golite062009
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.66767157264894 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  4.40961779134517 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  3.68838886134169 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.64567538445993 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.26293733853576 bayes_pls_golite062009
  • hydrolase activity
    		•  1.17086565360856 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • binding
    		•  0.994379083280533 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.893957699588543 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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