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View Structure Prediction Details

Protein: dnc-PM
Organism: Drosophila melanogaster
Length: 903 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for dnc-PM.

Description E-value Query
Range
Subject
Range
dnc-PB, FBpp0305507 - The gene dunce is referred to in FlyBase by the symbol Dmel\dnc (CG32498, FBgn0000479). It is a prot...
716.0 [0..87] [903..381]

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Predicted Domain #1
Region A:
Residues: [1-215]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPPPRRRRTA VAASAAAAAA ATTTTTTTTA TRAATTTPVT TAPTPTAITT TYRSRNLLKA  60
   61 TAKVKKKKKW KQISFVDDQQ RLKQAATSAE RKRSTSSAPP ALESNVPPRL GRFLRQKSSE 120
  121 TNSAATSAAA AAVQTEAETG RRKSSAASII AAAAGAAGLH NNNSSSCAAT ASEEQNSSGT 180
  181 LTGSSGNTST STWCGSINFL VYMVCSFCCC CYNFR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.06
Match: 1wx2B
Description: Crystal Structure of the oxy-form of the copper-bound Streptomyces castaneoglobisporus tyrosinase complexed with a caddie protein prepared by the addition of hydrogenperoxide
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [216-347]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSPFDVENGQ GARSPLEGGS PSAGLVLQNL PQRRESFLYR SDSDFEMSPK SMSRNSSIAS  60
   61 ERFKEQEASI LVDRSHGEDL IVTPFAQILA SLRSVRNNLL SLTNVPASNK SRRPNQSSSA 120
  121 SRSGNPPGAP LS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [348-470]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QGEEAYTRLA TDTIEELDWC LDQLETIQTH RSVSDMASLK FKRMLNKELS HFSESSRSGN  60
   61 QISEYICSTF LDKQQEFDLP SLRVEDNPEL VAANAAAGQQ SAGQYARSRS PRGPPMSQIS 120
  121 GVK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
cyclic-nucleotide phosphodiesterase activity 4.70762025272187 bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity 4.66767157264894 bayes_pls_golite062009
phosphoric diester hydrolase activity 4.40961779134517 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 3.68838886134169 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 2.64567538445993 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.26293733853576 bayes_pls_golite062009
hydrolase activity 1.17086565360856 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
binding 0.994379083280533 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.893957699588543 bayes_pls_golite062009
protein binding 0.162314119157812 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [471-903]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPLSHTNSFT GERLPTFGVE TPRENELGTL LGELDTWGIQ IFSIGEFSVN RPLTCVAYTI  60
   61 FQSRELLTSL MIPPKTFLNF MSTLEDHYVK DNPFHNSLHA ADVTQSTNVL LNTPALEGVF 120
  121 TPLEVGGALF AACIHDVDHP GLTNQFLVNS SSELALMYND ESVLENHHLA VAFKLLQNQG 180
  181 CDIFCNMQKK QRQTLRKMVI DIVLSTDMSK HMSLLADLKT MVETKKVAGS GVLLLDNYTD 240
  241 RIQVLENLVH CADLSNPTKP LPLYKRWVAL LMEEFFLQGD KERESGMDIS PMCDRHNATI 300
  301 EKSQVGFIDY IVHPLWETWA DLVHPDAQDI LDTLEENRDY YQSMIPPSPP PSGVDENPQE 360
  361 DRIRFQVTLE ESDQENLAEL EEGDESGGES TTTGTTGTTA ASALSGAGGG GGGGGGMAPR 420
  421 TGGCQNQPQH GGM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 141.0
Match: 2fm0A
Description: No description for 2fm0A was found.

Predicted functions:

Term Confidence Notes
cyclic-nucleotide phosphodiesterase activity 4.70762025272187 bayes_pls_golite062009
3',5'-cyclic-nucleotide phosphodiesterase activity 4.66767157264894 bayes_pls_golite062009
phosphoric diester hydrolase activity 4.40961779134517 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 3.68838886134169 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 2.64567538445993 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 1.26293733853576 bayes_pls_golite062009
hydrolase activity 1.17086565360856 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
binding 0.994379083280533 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.893957699588543 bayes_pls_golite062009
protein binding 0.162314119157812 bayes_pls_golite062009

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