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Protein Overview: crn-PA

General Information:
Name(s) found: crn-PA / FBpp0070402 [FlyBase]
Description(s) found:
Found 27 descriptions.
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  • The gene crooked neck is referred to in FlyBase by the symbol Dmel\crn (CG3193, FBgn0000377). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2141610..2144014. It has the cytological map location 2F2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: binding. There is experimental evidence that it is involved in the biological process</span>: Malpighian tubule morphogenesis; regulation of alternative nuclear mRNA splicing, via spliceosome. 37 alleles are reported. The phenotypes of these alleles are annotated with: Malpighian tubule; embryonic Malpighian tubule; embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 702 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][NAS]
    catalytic step 2 spliceosome [IDA]
    nuclear speck [IDA]
    precatalytic spliceosome [IDA]
    spliceosomal complex [ISS]
    Biological Process: neuroblast proliferation [NAS]
    oenocyte development [IMP]
    central nervous system development [NAS]
    regulation of alternative nuclear mRNA splicing, via spliceosome [IMP]
    neuron fate commitment [NAS]
    Malpighian tubule morphogenesis [IMP]
    peripheral nervous system development [NAS]
    axon ensheathment [IMP]
    nuclear mRNA splicing, via spliceosome [IC][ISS]
    glial cell migration [IMP]
    Molecular Function: binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MERPQKMPKV AKVKNKAPAE VQITAEQLLR EAKERDLEIL PPPPKQKISD PAELADYQQR  60
   61 KRKTFEDNLR KNRMVVSHWI KYAQWEEQQQ EIQRARSIWE RALDNEHRNV TLWLKYAEME 120
  121 MKNKQVNHAR NLWDRAVTIM PRVNQFWYKY TYMEEMLENV AGARQVFERW MEWQPEEQAW 180
  181 QTYVNFELRY KEIDRAREIY ERFVYVHPDV KNWIKFARFE ESHGFIHGSR RVFERAVEFF 240
  241 GDDYIEERLF IAFARFEEGQ KEHDRARIIY KYALDHLPKD RTQELFKAYT KHEKKYGDRA 300
  301 GIEDVIVSKR KYQYEQEVAA NPTNYDAWFD YLRLIEAEGD RDQIRETYER AISNVPPANE 360
  361 KNFWRRYIYL WINYALYEEL EAEDAERTRQ IYKTCLELIP HKQFTFSKLW LLYAQFEIRC 420
  421 KELQRARKAL GLAIGMCPRD KLFRGYIDLE IQLREFERCR MLYEKFLEFG PENCVTWMKF 480
  481 AELENLLGDT DRARAIFELA VQQPRLDMPE LLWKAYIDFE VALGETELAR QLYERLLERT 540
  541 QHVKVWMSFA KFEMGLSHGD SGPDAELNVQ LARRIYERAN EMLRQLGDKE SRVLLLEAWR 600
  601 DFERDASDSQ EMQKVMDKMP RRIKKRQKIV SDNGVEEGWE EVFDYIFPED EMARPNLKLL 660
  661 AAAKMWKTQK DNTVDDPPAT AIASEPEPAA DAAPADTTDS GD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..175] PSI-BLAST 50.0 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
    2 View Details [176..702] PSI-BLAST 26.69897 No description for 2gw1A was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle