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Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. A nucleoplasmic speckle distributed in the interchromatin space of cells in close proximity to chromatin. Omega speckles are distinct from interchromatin granules and contain heterogeneous nuclear RNA-binding proteins (hnRNPs). Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: nuclear speck
Acc: GO:0016607
Aspect: Cellular Component
Desc: A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
Synonyms:
  • speckle focus
  • nuclear speckles
  • speckle domain
  • nuclear speckle
  • splicing speckle
Proteins in PDR annotated with:
   This term: 119 [Search]
   Term or descendants: 130 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0016607 - nuclear speck (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle