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Protein Overview: sc-PA

General Information:
Name(s) found: sc-PA / FBpp0070072 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene scute is referred to in FlyBase by the symbol Dmel\sc (CG3827, FBgn0004170). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:290093..291530. It has the cytological map location 1A8. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process</span>: sensory organ development; negative regulation of apoptosis; nervous system development; bristle morphogenesis; peripheral nervous system development; sex determination. 179 alleles are reported. The phenotypes of these alleles are annotated with 62 unique terms, many of which group under: adult segment; peripheral nervous system; adult mesothoracic segment; nervous system; adult external prothorax; postalar bristle; humeral trabecule; anterior vertical bristle; embryonic nervous system; anterior orbital bristle; dorsal thoracic disc; antennal segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 345 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS]
    Biological Process: nervous system development [IGI][TAS]
    neuroblast fate determination [NAS][TAS]
    peripheral nervous system development [IMP][NAS][TAS]
    regulation of transcription, DNA-dependent [NAS]
    sex determination, establishment of X:A ratio [NAS][TAS]
    sex determination [IGI][IMP][NAS][TAS]
    regulation of transcription [IEA]
    regulation of mitotic cell cycle [TAS]
    sensory organ development [IMP]
    regulation of transcription from RNA polymerase II promoter [ISS]
    ventral cord development [NAS]
    bristle morphogenesis [IMP][NAS]
    central nervous system development [NAS][TAS]
    dosage compensation [NAS]
    negative regulation of apoptosis [IMP]
    Molecular Function: DNA binding [NAS][TAS]
    protein heterodimerization activity [IPI]
    specific RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNNNNTTKS TTMSSSVLST NETFPTTINS ATKIFRYQHI MPAPSPLIPG GNQNQPAGTM  60
   61 PIKTRKYTPR GMALTRCSES VSSLSPGSSP APYNVDQSQS VQRRNARERN RVKQVNNSFA 120
  121 RLRQHIPQSI ITDLTKGGGR GPHKKISKVD TLRIAVEYIR RLQDLVDDLN GGSNIGANNA 180
  181 VTQLQLCLDE SSSHSSSSST CSSSGHNTYY QNTISVSPLQ QQQQLQRQQF NHQPLTALSL 240
  241 NTNLVGTSVP GGDAGCVSTS KNQQTCHSPT SSFNSSMSFD SGTYEGVPQQ ISTHLDRLDH 300
  301 LDNELHTHSQ LQLKFEPYEH FQLDEEDCTP DDEEILDYIS LWQEQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] deduced N/A No confident structure predictions are available.
    2 View Details [90..186] PSI-BLAST 12.30103 SREBP-1a
    3 View Details [187..345] MSA 2.296991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.38658950816179 bayes_pls_golite062009
  • DNA binding
    		•  5.18654839258297 bayes_pls_golite062009
  • nucleic acid binding
    		•  5.05768805749761 bayes_pls_golite062009
  • transcription factor activity
    		•  4.78039531631248 bayes_pls_golite062009
  • binding
    		•  3.81829206350975 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.39500382187264 bayes_pls_golite062009
  • transcription factor binding
    		•  2.61163564741984 bayes_pls_golite062009
  • transcription activator activity
    		•  2.5495467409976 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity, enhancer binding
    		•  2.42306484786159 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.31910036997977 bayes_pls_golite062009
  • protein binding
    		•  1.59929864805879 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.52770895937238 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.955588849035129 bayes_pls_golite062009
  • promoter binding
    		•  0.8576109846276 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.801830750183111 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.3513586903977 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle