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Protein Overview: Ank-PE, Ank-PD, ...

General Information:
Name(s) found: Ank-PE / FBpp0289724 [FlyBase]
Ank-PB / FBpp0088240 [FlyBase]
Ank-PD / FBpp0088239 [FlyBase]
Ank-PC / FBpp0088238 [FlyBase]
Description(s) found:
Found 67 descriptions.
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  • The gene Ankyrin is referred to in FlyBase by the symbol Dmel\Ank (CG1651, FBgn0011747). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:137015..150378. It has the cytological map location 102A3. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: cytoskeletal anchoring at plasma membrane. 7 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Ankyrin is referred to in FlyBase by the symbol Dmel\Ank (CG1651, FBgn0011747). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:137015..150378. It has the cytological map location 102A3. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: cytoskeletal anchoring at plasma membrane. 7 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Ankyrin is referred to in FlyBase by the symbol Dmel\Ank (CG1651, FBgn0011747). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:137015..150378. It has the cytological map location 102A3. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: cytoskeletal anchoring at plasma membrane. 7 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
  • The gene Ankyrin is referred to in FlyBase by the symbol Dmel\Ank (CG1651, FBgn0011747). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:137015..150378. It has the cytological map location 102A3. Based on sequence similarity, it is predicted to have molecular function</span>: structural constituent of cytoskeleton; cytoskeletal protein binding. There is experimental evidence that it is involved in the biological process</span>: cytoskeletal anchoring at plasma membrane. 7 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1549 amino acids

    Gene Ontology:
    Cellular Component: [NOT]fusome [IDA][NAS]
    spectrosome [IDA][TAS]
    plasma membrane [IDA]
    Biological Process: signal transduction [IEA]
    cytoskeletal anchoring at plasma membrane [IDA]
    Molecular Function: protein binding [IEA]
    structural constituent of cytoskeleton [ISS]
    cytoskeletal protein binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLGDVRVEN KIQTRSETCA INGMALDNKN GIIKQNDATI SFLRAARSGD IKKVMDFLDC  60
   61 GEISDINSCN ANGLNALHLA AKDGYVDICC ELLRRGIKID NATKKGNTAL HIASLAGQHD 120
  121 VINQLILYNA NVNVQSLNGF TPLYMAAQEN HDNCCRTLLA NGANPSLSTE DGFTPLAVAM 180
  181 QQGHDKIVAV LLENDVRGKV RLPALHIAAK KNDVNAAKLL LQHDPNADIV SKSGFTPLHI 240
  241 AAHYGNVDIA TLLLNNKADV NYVAKHNITP LHVACKWGKL SLCTLLLCRG AKIDAATRDG 300
  301 LTPLHCASRS GHVEVIKHLL QQNAPILTKT KNGLSALHMA AQGEHDEAAH LLLDNKAPVD 360
  361 EVTVDYLTAL HVAAHCGHVK VAKLLLDYKA NPNARALNGF TPLHIACKKN RIKMVELLIK 420
  421 HGANIGATTE SGLTPLHVAS FMGCINIVIY LLQHEASADL PTIRGETPLH LAARANQADI 480
  481 IRILLRSAKV DAIAREGQTP LHVASRLGNI NIIMLLLQHG AEINAQSNDK YSALHIAAKE 540
  541 GQENIVQVLL ENGAENNAVT KKGFTPLHLA CKYGKQNVVQ ILLQNGASID FQGKNDVTPL 600
  601 HVATHYNNPS IVELLLKNGS SPNLCARNGQ CAIHIACKKN YLEIAMQLLQ HGADVNIISK 660
  661 SGFSPLHLAA QGGNVDMVQL LLEYGVISAA AKNGLTPLHV AAQEGHVLVS QILLEHGANI 720
  721 SERTRNGYTP LHMAAHYGHL DLVKFFIEND ADIEMSSNIG YTPLHQAAQQ GHIMIINLLL 780
  781 RHKANPNALT KDGNTALHIA SNLGYVTVME SLKIVTSTSV INSNIGAIEE KLKVMTPELM 840
  841 QETLLSDSDD ESCDDLLDHN HYKYMATDDL KANYGQDQKN FDTTNTDHDL TDVSVLNKKE 900
  901 ILPNEMSCIE LTEIGHKPDN VVIARSQVHL GFLVSFLVDA RGGSMRGYRH NGVRIIVPPK 960
  961 ACAEPTRITC RYVKPQRVVN PPPLMEGEAL VSRILEMSPV DGMFLSPITL EVPHYGTLRK1020
 1021 NEREIIILRS DNGESWREHN LYKDIIGEDI NQTEEFHSDR IVRIVTQNVP HFFAVVSRVR1080
 1081 QEVHVIGPDG GTVFSTAVPQ VKAIFPPHAL TKKIRVGLQA QSVDLVECSK LLGQGVAVSP1140
 1141 VVTVEPRRRK FHKAITLSIP APKACTNSMV NACYGNGNSS SPTLRLLCSI SGGQTRATWE1200
 1201 DVTGSTPLSF VRDSVTFTTT VSARFWLIDC RNIIDAGRMA TELYSHLAKV PFYVKFVIFA1260
 1261 KRISQTEAKF SVFCMTDDKE DKTLEQQEYF KEVAKSRDIE VLQNQIVYLE FAGNIVPILK1320
 1321 KGEQLYTKFQ PFCENRLSFS AHIKDQEFPH GRICFMTYPM VGPDEVPLKP LCTLNISVDF1380
 1381 KTITNHLERD NLHSLNDCIN AHGKLNHNEN IVFGVKEQQV KKIDITKACI MSSDIKLIHE1440
 1441 ADVILDDICS HLGSDWPLLA NVLGVSQADI DLVKTEFLLN DSVKQSMAML QLWLEHGGIL1500
 1501 TGNVLAEALY KIGRSDIVEK SFKNAEFGTH QPEKVLPTAG IEKDGDYEQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 25.69897 p18ink4C(ink6)
    2 View Details [195..428] PSI-BLAST 60.0 Crystal structure of ribonuclease
    3 View Details [429..495] PSI-BLAST 15.69897 No description for 2nyjA was found.
    4 View Details [496..903] PSI-BLAST 126.0 Ankyrin-R
    5 View Details [904..1057] Pfam 65.366532 No description for PF00791.11 was found. No confident structure predictions are available.
    6 View Details [1058..1178] deduced N/A No confident structure predictions are available.
    7 View Details [1179..1420] deduced N/A No confident structure predictions are available.
    8 View Details [1421..1549] PSI-BLAST 7.09691 No description for 2of5H was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.30812396303844 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.74680100300795 bayes_pls_golite062009
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.4948065111495 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • actin binding
    		•  1.57116090936036 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.55735067984073 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • signal transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.13900029077952 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.996021523724457 bayes_pls_golite062009
  • kinase activity
    		•  0.973206891506661 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.954469238725827 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.876784788207113 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.835937200249181 bayes_pls_golite062009
  • structural molecule activity
    		•  0.808967137205604 bayes_pls_golite062009
  • protein kinase binding
    		•  0.78130842943004 bayes_pls_golite062009
  • kinase binding
    		•  0.75961315755729 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.673886572785743 bayes_pls_golite062009
  • protein kinase activity
    		•  0.663511836722598 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.513166854694801 bayes_pls_golite062009
  • receptor activity
    		•  0.406585818104982 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.362731457946887 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.362731457946887 bayes_pls_golite062009
  • lipoprotein binding
    		•  0.357621368111932 bayes_pls_golite062009
  • actin filament binding
    		•  0.356911481111024 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.313073396797741 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.311071169071639 bayes_pls_golite062009
  • channel activity
    		•  0.311071169071639 bayes_pls_golite062009
  • transferase activity
    		•  0.298084176742023 bayes_pls_golite062009
  • gated channel activity
    		•  0.26482178002103 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.195884522327237 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.16400377449991 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.138817775143484 bayes_pls_golite062009
  • ion channel activity
    		•  0.0750047276635097 bayes_pls_golite062009
  • protein serine/threonine kinase inhibitor activity
    		•  0.0500658306142403 bayes_pls_golite062009
    2
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.30812396303844 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.74680100300795 bayes_pls_golite062009
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.4948065111495 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • actin binding
    		•  1.57116090936036 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.55735067984073 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • signal transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.13900029077952 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.996021523724457 bayes_pls_golite062009
  • kinase activity
    		•  0.973206891506661 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.954469238725827 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.876784788207113 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.835937200249181 bayes_pls_golite062009
  • structural molecule activity
    		•  0.808967137205604 bayes_pls_golite062009
  • protein kinase binding
    		•  0.78130842943004 bayes_pls_golite062009
  • kinase binding
    		•  0.75961315755729 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.673886572785743 bayes_pls_golite062009
  • protein kinase activity
    		•  0.663511836722598 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.513166854694801 bayes_pls_golite062009
  • receptor activity
    		•  0.406585818104982 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.362731457946887 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.362731457946887 bayes_pls_golite062009
  • lipoprotein binding
    		•  0.357621368111932 bayes_pls_golite062009
  • actin filament binding
    		•  0.356911481111024 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.313073396797741 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.311071169071639 bayes_pls_golite062009
  • channel activity
    		•  0.311071169071639 bayes_pls_golite062009
  • transferase activity
    		•  0.298084176742023 bayes_pls_golite062009
  • gated channel activity
    		•  0.26482178002103 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.195884522327237 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.16400377449991 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.138817775143484 bayes_pls_golite062009
  • ion channel activity
    		•  0.0750047276635097 bayes_pls_golite062009
  • protein serine/threonine kinase inhibitor activity
    		•  0.0500658306142403 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  3.30812396303844 bayes_pls_golite062009
  • cyclin-dependent protein kinase regulator activity
    		•  2.74680100300795 bayes_pls_golite062009
  • protein binding
    		•  2.69918165732603 bayes_pls_golite062009
  • binding
    		•  2.60916417202222 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  2.4948065111495 bayes_pls_golite062009
  • hydrolase activity
    		•  2.43232200709693 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.37103377984038 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.8957142857582 bayes_pls_golite062009
  • DNA binding
    		•  1.78305438715057 bayes_pls_golite062009
  • transcription activator activity
    		•  1.6418915400902 bayes_pls_golite062009
  • actin binding
    		•  1.57116090936036 bayes_pls_golite062009
  • cyclin-dependent protein kinase inhibitor activity
    		•  1.55735067984073 bayes_pls_golite062009
  • transcription factor activity
    		•  1.2667825651547 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • signal transducer activity
    		•  1.2375987667709 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.23556500721571 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.13900029077952 bayes_pls_golite062009
  • transcription factor binding
    		•  1.06366405671195 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.996021523724457 bayes_pls_golite062009
  • kinase activity
    		•  0.973206891506661 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.954469238725827 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.949906091645366 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.876784788207113 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.835937200249181 bayes_pls_golite062009
  • structural molecule activity
    		•  0.808967137205604 bayes_pls_golite062009
  • protein kinase binding
    		•  0.78130842943004 bayes_pls_golite062009
  • kinase binding
    		•  0.75961315755729 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.673886572785743 bayes_pls_golite062009
  • protein kinase activity
    		•  0.663511836722598 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.590503097160372 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.513166854694801 bayes_pls_golite062009
  • receptor activity
    		•  0.406585818104982 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.362731457946887 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.362731457946887 bayes_pls_golite062009
  • lipoprotein binding
    		•  0.357621368111932 bayes_pls_golite062009
  • actin filament binding
    		•  0.356911481111024 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.313073396797741 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  0.311071169071639 bayes_pls_golite062009
  • channel activity
    		•  0.311071169071639 bayes_pls_golite062009
  • transferase activity
    		•  0.298084176742023 bayes_pls_golite062009
  • gated channel activity
    		•  0.26482178002103 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.247967126091535 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.195884522327237 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  0.16400377449991 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.138817775143484 bayes_pls_golite062009
  • ion channel activity
    		•  0.0750047276635097 bayes_pls_golite062009
  • protein serine/threonine kinase inhibitor activity
    		•  0.0500658306142403 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle