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View Structure Prediction Details

Protein: Ank-PE, Ank-PD, ...
Organism: Drosophila melanogaster
Length: 1549 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ank-PE, Ank-PD, ....

Description E-value Query
Range		 Subject
Range
gi|109075435 - gi|109075435|ref|XP_001094664.1| PREDICTED: ankyrin 2, neuronal isoform 6 [Macaca mulatta]
 1790.0 [0..36] [1542..29]

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Predicted Domain #1
Region A:
Residues: [1-194] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLGDVRVEN KIQTRSETCA INGMALDNKN GIIKQNDATI SFLRAARSGD IKKVMDFLDC  60
   61 GEISDINSCN ANGLNALHLA AKDGYVDICC ELLRRGIKID NATKKGNTAL HIASLAGQHD 120
  121 VINQLILYNA NVNVQSLNGF TPLYMAAQEN HDNCCRTLLA NGANPSLSTE DGFTPLAVAM 180
  181 QQGHDKIVAV LLEN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 25.69897
Match: 1mx4A
Description: p18ink4C(ink6)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.30812396303844 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.74680100300795 bayes_pls_golite062009
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
structural constituent of cytoskeleton 2.4948065111495 bayes_pls_golite062009
hydrolase activity 2.43232200709693 bayes_pls_golite062009
transcription regulator activity 2.37103377984038 bayes_pls_golite062009
nucleic acid binding 1.8957142857582 bayes_pls_golite062009
DNA binding 1.78305438715057 bayes_pls_golite062009
transcription activator activity 1.6418915400902 bayes_pls_golite062009
actin binding 1.57116090936036 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.55735067984073 bayes_pls_golite062009
transcription factor activity 1.2667825651547 bayes_pls_golite062009
molecular transducer activity 1.2375987667709 bayes_pls_golite062009
signal transducer activity 1.2375987667709 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.23556500721571 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
small conjugating protein ligase activity 1.13900029077952 bayes_pls_golite062009
transcription factor binding 1.06366405671195 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
transcription repressor activity 0.996021523724457 bayes_pls_golite062009
kinase activity 0.973206891506661 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.954469238725827 bayes_pls_golite062009
sequence-specific DNA binding 0.949906091645366 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.876784788207113 bayes_pls_golite062009
substrate-specific transporter activity 0.835937200249181 bayes_pls_golite062009
structural molecule activity 0.808967137205604 bayes_pls_golite062009
protein kinase binding 0.78130842943004 bayes_pls_golite062009
kinase binding 0.75961315755729 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.673886572785743 bayes_pls_golite062009
protein kinase activity 0.663511836722598 bayes_pls_golite062009
enzyme binding 0.60140077251711 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.590503097160372 bayes_pls_golite062009
ion transmembrane transporter activity 0.513166854694801 bayes_pls_golite062009
receptor activity 0.406585818104982 bayes_pls_golite062009
mechanically-gated ion channel activity 0.362731457946887 bayes_pls_golite062009
mechanically gated channel activity 0.362731457946887 bayes_pls_golite062009
lipoprotein binding 0.357621368111932 bayes_pls_golite062009
actin filament binding 0.356911481111024 bayes_pls_golite062009
nuclear localization sequence binding 0.313073396797741 bayes_pls_golite062009
passive transmembrane transporter activity 0.311071169071639 bayes_pls_golite062009
channel activity 0.311071169071639 bayes_pls_golite062009
transferase activity 0.298084176742023 bayes_pls_golite062009
gated channel activity 0.26482178002103 bayes_pls_golite062009
acid-amino acid ligase activity 0.247967126091535 bayes_pls_golite062009
transmembrane receptor activity 0.195884522327237 bayes_pls_golite062009
substrate-specific channel activity 0.16400377449991 bayes_pls_golite062009
cation transmembrane transporter activity 0.138817775143484 bayes_pls_golite062009
ion channel activity 0.0750047276635097 bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity 0.0500658306142403 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [195-428] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVRGKVRLPA LHIAAKKNDV NAAKLLLQHD PNADIVSKSG FTPLHIAAHY GNVDIATLLL  60
   61 NNKADVNYVA KHNITPLHVA CKWGKLSLCT LLLCRGAKID AATRDGLTPL HCASRSGHVE 120
  121 VIKHLLQQNA PILTKTKNGL SALHMAAQGE HDEAAHLLLD NKAPVDEVTV DYLTALHVAA 180
  181 HCGHVKVAKL LLDYKANPNA RALNGFTPLH IACKKNRIKM VELLIKHGAN IGAT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 60.0
Match: 1wdyA
Description: Crystal structure of ribonuclease
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.30812396303844 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.74680100300795 bayes_pls_golite062009
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
structural constituent of cytoskeleton 2.4948065111495 bayes_pls_golite062009
hydrolase activity 2.43232200709693 bayes_pls_golite062009
transcription regulator activity 2.37103377984038 bayes_pls_golite062009
nucleic acid binding 1.8957142857582 bayes_pls_golite062009
DNA binding 1.78305438715057 bayes_pls_golite062009
transcription activator activity 1.6418915400902 bayes_pls_golite062009
actin binding 1.57116090936036 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.55735067984073 bayes_pls_golite062009
transcription factor activity 1.2667825651547 bayes_pls_golite062009
molecular transducer activity 1.2375987667709 bayes_pls_golite062009
signal transducer activity 1.2375987667709 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.23556500721571 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
small conjugating protein ligase activity 1.13900029077952 bayes_pls_golite062009
transcription factor binding 1.06366405671195 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
transcription repressor activity 0.996021523724457 bayes_pls_golite062009
kinase activity 0.973206891506661 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.954469238725827 bayes_pls_golite062009
sequence-specific DNA binding 0.949906091645366 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.876784788207113 bayes_pls_golite062009
substrate-specific transporter activity 0.835937200249181 bayes_pls_golite062009
structural molecule activity 0.808967137205604 bayes_pls_golite062009
protein kinase binding 0.78130842943004 bayes_pls_golite062009
kinase binding 0.75961315755729 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.673886572785743 bayes_pls_golite062009
protein kinase activity 0.663511836722598 bayes_pls_golite062009
enzyme binding 0.60140077251711 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.590503097160372 bayes_pls_golite062009
ion transmembrane transporter activity 0.513166854694801 bayes_pls_golite062009
receptor activity 0.406585818104982 bayes_pls_golite062009
mechanically-gated ion channel activity 0.362731457946887 bayes_pls_golite062009
mechanically gated channel activity 0.362731457946887 bayes_pls_golite062009
lipoprotein binding 0.357621368111932 bayes_pls_golite062009
actin filament binding 0.356911481111024 bayes_pls_golite062009
nuclear localization sequence binding 0.313073396797741 bayes_pls_golite062009
passive transmembrane transporter activity 0.311071169071639 bayes_pls_golite062009
channel activity 0.311071169071639 bayes_pls_golite062009
transferase activity 0.298084176742023 bayes_pls_golite062009
gated channel activity 0.26482178002103 bayes_pls_golite062009
acid-amino acid ligase activity 0.247967126091535 bayes_pls_golite062009
transmembrane receptor activity 0.195884522327237 bayes_pls_golite062009
substrate-specific channel activity 0.16400377449991 bayes_pls_golite062009
cation transmembrane transporter activity 0.138817775143484 bayes_pls_golite062009
ion channel activity 0.0750047276635097 bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity 0.0500658306142403 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [429-495] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TESGLTPLHV ASFMGCINIV IYLLQHEASA DLPTIRGETP LHLAARANQA DIIRILLRSA  60
   61 KVDAIAR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.69897
Match: 2nyjA
Description: No description for 2nyjA was found.

Predicted Domain #4
Region A:
Residues: [496-903] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGQTPLHVAS RLGNINIIML LLQHGAEINA QSNDKYSALH IAAKEGQENI VQVLLENGAE  60
   61 NNAVTKKGFT PLHLACKYGK QNVVQILLQN GASIDFQGKN DVTPLHVATH YNNPSIVELL 120
  121 LKNGSSPNLC ARNGQCAIHI ACKKNYLEIA MQLLQHGADV NIISKSGFSP LHLAAQGGNV 180
  181 DMVQLLLEYG VISAAAKNGL TPLHVAAQEG HVLVSQILLE HGANISERTR NGYTPLHMAA 240
  241 HYGHLDLVKF FIENDADIEM SSNIGYTPLH QAAQQGHIMI INLLLRHKAN PNALTKDGNT 300
  301 ALHIASNLGY VTVMESLKIV TSTSVINSNI GAIEEKLKVM TPELMQETLL SDSDDESCDD 360
  361 LLDHNHYKYM ATDDLKANYG QDQKNFDTTN TDHDLTDVSV LNKKEILP

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 126.0
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cytoskeletal protein binding 3.30812396303844 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 2.74680100300795 bayes_pls_golite062009
protein binding 2.69918165732603 bayes_pls_golite062009
binding 2.60916417202222 bayes_pls_golite062009
structural constituent of cytoskeleton 2.4948065111495 bayes_pls_golite062009
hydrolase activity 2.43232200709693 bayes_pls_golite062009
transcription regulator activity 2.37103377984038 bayes_pls_golite062009
nucleic acid binding 1.8957142857582 bayes_pls_golite062009
DNA binding 1.78305438715057 bayes_pls_golite062009
transcription activator activity 1.6418915400902 bayes_pls_golite062009
actin binding 1.57116090936036 bayes_pls_golite062009
cyclin-dependent protein kinase inhibitor activity 1.55735067984073 bayes_pls_golite062009
transcription factor activity 1.2667825651547 bayes_pls_golite062009
molecular transducer activity 1.2375987667709 bayes_pls_golite062009
signal transducer activity 1.2375987667709 bayes_pls_golite062009
ubiquitin-protein ligase activity 1.23556500721571 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
small conjugating protein ligase activity 1.13900029077952 bayes_pls_golite062009
transcription factor binding 1.06366405671195 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
transcription repressor activity 0.996021523724457 bayes_pls_golite062009
kinase activity 0.973206891506661 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.954469238725827 bayes_pls_golite062009
sequence-specific DNA binding 0.949906091645366 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.876784788207113 bayes_pls_golite062009
substrate-specific transporter activity 0.835937200249181 bayes_pls_golite062009
structural molecule activity 0.808967137205604 bayes_pls_golite062009
protein kinase binding 0.78130842943004 bayes_pls_golite062009
kinase binding 0.75961315755729 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.673886572785743 bayes_pls_golite062009
protein kinase activity 0.663511836722598 bayes_pls_golite062009
enzyme binding 0.60140077251711 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.590503097160372 bayes_pls_golite062009
ion transmembrane transporter activity 0.513166854694801 bayes_pls_golite062009
receptor activity 0.406585818104982 bayes_pls_golite062009
mechanically-gated ion channel activity 0.362731457946887 bayes_pls_golite062009
mechanically gated channel activity 0.362731457946887 bayes_pls_golite062009
lipoprotein binding 0.357621368111932 bayes_pls_golite062009
actin filament binding 0.356911481111024 bayes_pls_golite062009
nuclear localization sequence binding 0.313073396797741 bayes_pls_golite062009
passive transmembrane transporter activity 0.311071169071639 bayes_pls_golite062009
channel activity 0.311071169071639 bayes_pls_golite062009
transferase activity 0.298084176742023 bayes_pls_golite062009
gated channel activity 0.26482178002103 bayes_pls_golite062009
acid-amino acid ligase activity 0.247967126091535 bayes_pls_golite062009
transmembrane receptor activity 0.195884522327237 bayes_pls_golite062009
substrate-specific channel activity 0.16400377449991 bayes_pls_golite062009
cation transmembrane transporter activity 0.138817775143484 bayes_pls_golite062009
ion channel activity 0.0750047276635097 bayes_pls_golite062009
protein serine/threonine kinase inhibitor activity 0.0500658306142403 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [904-1057] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NEMSCIELTE IGHKPDNVVI ARSQVHLGFL VSFLVDARGG SMRGYRHNGV RIIVPPKACA  60
   61 EPTRITCRYV KPQRVVNPPP LMEGEALVSR ILEMSPVDGM FLSPITLEVP HYGTLRKNER 120
  121 EIIILRSDNG ESWREHNLYK DIIGEDINQT EEFH

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 65.366532
Match: PF00791.11
Description: No description for PF00791.11 was found.

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6
Region A:
Residues: [1058-1178] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDRIVRIVTQ NVPHFFAVVS RVRQEVHVIG PDGGTVFSTA VPQVKAIFPP HALTKKIRVG  60
   61 LQAQSVDLVE CSKLLGQGVA VSPVVTVEPR RRKFHKAITL SIPAPKACTN SMVNACYGNG 120
  121 N

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [1179-1420] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSPTLRLLC SISGGQTRAT WEDVTGSTPL SFVRDSVTFT TTVSARFWLI DCRNIIDAGR  60
   61 MATELYSHLA KVPFYVKFVI FAKRISQTEA KFSVFCMTDD KEDKTLEQQE YFKEVAKSRD 120
  121 IEVLQNQIVY LEFAGNIVPI LKKGEQLYTK FQPFCENRLS FSAHIKDQEF PHGRICFMTY 180
  181 PMVGPDEVPL KPLCTLNISV DFKTITNHLE RDNLHSLNDC INAHGKLNHN ENIVFGVKEQ 240
  241 QV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8
Region A:
Residues: [1421-1549] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKIDITKACI MSSDIKLIHE ADVILDDICS HLGSDWPLLA NVLGVSQADI DLVKTEFLLN  60
   61 DSVKQSMAML QLWLEHGGIL TGNVLAEALY KIGRSDIVEK SFKNAEFGTH QPEKVLPTAG 120
  121 IEKDGDYEQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.09691
Match: 2of5H
Description: No description for 2of5H was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle