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Protein Overview: Gcn2-PA, FBpp0306618

General Information:
Name(s) found: FBpp0306618 [FlyBase]
Gcn2-PA / FBpp0085148 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=3R:join(27221713..27221778,27221845..27222014,27222124..27222629,27222708..27223335,27223389..27223961,27224027..27224203,27224268..27224766,27224825..27225877,27225940..27226910,27226973..27227099); ID=FBpp0306618; name=Gcn2-PB; parent=FBgn0019990,FBtr0334551; dbxref=FlyBase:FBpp0306618,FlyBase_Annotation_IDs:CG1609-PB,REFSEQ:NP_001263141,GB_protein:AGB96520; MD5=83300fb3c7aa4d951a0d50fb10ecadc8; length=1589; release=r5.56; species=Dmel; [FlyBase]
  • The gene Gcn2 is referred to in FlyBase by the symbol Dmel\Gcn2 (CG1609, FBgn0019990). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:27221380..27227735. It has the cytological map location 100C3. There is experimental evidence that it has the molecular function</span>: elongation factor-2 kinase activity. There is experimental evidence that it is involved in the biological process</span>: protein amino acid phosphorylation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1589 amino acids

    Gene Ontology:
    Cellular Component: catalytic step 2 spliceosome [IDA]
    precatalytic spliceosome [IDA]
    cytosol [IC]
    Biological Process: regulation of translation [IC]
    protein amino acid phosphorylation [IDA][NAS]
    nuclear mRNA splicing, via spliceosome [IC]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [NAS]
    elongation factor-2 kinase activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MADEKAKESF RERQAQELEV IKSIFGCDVE DLRPQANPSL WKPTDIRIQL TPLRDSSNGL  60
   61 ETYVCTKLHV TCPSKYPKLP PKISLEESKG MSDQLLEALR NQLQAQSQEL RGEVMIYELA 120
  121 QTVQAFLLEH NKPPKGSFYD QMLQDKQKRD QELQDIQRQR ESLQRQTLID EVERRKEMFK 180
  181 TEAKRRGEPR RSMSESNPRH PSSSESSENS SPYYRGHIYP SKCLDHRNTE TLYFHKMGRQ 240
  241 IQRGCCVGHS QRGCIAYTGI DMHCGQLLYI TEWNIKYSQL EQPCIGGGKC HWSSESKCMG 300
  301 SHRVDEVMAS IEKQVSSLSQ LQHKNLVSYE CVLCIKRKEG LLVYLVQDFL LGTSVFSISS 360
  361 SLGWCMDGAR MVARGVLDAL VFLHNKGVSH SHLLDTTVFM DNTGNVRVSD FSLVPNLLEL 420
  421 LSGAGQSSSC GDLPALGALV ESLMPTNSYE MRDFVDKCNS DRTLSASELL EHPFLRFYVD 480
  481 NGQQQVMPLP QQQHPNTVQR TGSAMPYQIP TLALSQSRLR TEFEVLMYLG KGAFGDVLKV 540
  541 RNILDNREYA IKRIPLPARS RQLYKKMTRE VELLSRLNHE NVVRYFNSWI ESVDDADAAE 600
  601 MDKLLGGEWS QSQQDLSVKP AKSPQLGPTL EEDEDEEDSS SSMWNGYIPN MEDSDSDGIE 660
  661 FVDSNGKVAV YDDEEQEDST RGKTNSPKPL MQVMYIQMEF CEKCTLRTAI DDNLFNDTDR 720
  721 LWRLFREIAE GLAHIHQQGI IHRDLKPVNI FLDSHDQIKI GDFGLATTSF LALQAHDAAP 780
  781 APVNQITSAE DGTGTGKVGT TLYVAPELTG NASKSVYNQK VDMYTLGIIL FEMCQPPFDT 840
  841 SMERAQTIMA LRNVSINIPD AMLKDPKYEK TVKMLQWLLN HDPAQRPTAE ELLISDLVPP 900
  901 AQLEANELQE MLRHALANPQ SKAYKNLVAR CLQQESDEVL EHTYHLGSSR AMKSWNSAII 960
  961 IDDIVSLNPV IEFVKAKVVN LFRKHGAIEV DSPLLSPLSA RNSTANANAN AVHLMTHSGC1020
 1021 VVVLPCDLRT QFARHVTMNS VNLIRRYCVD RVYREERVFN FHPKQSYDCS FDIIAPTTGS1080
 1081 HLVDAELLSL AFEITSELPR LREKNLAIRM NHTNLLRAIL IFCNVPKAQY GALFEGTMDF1140
 1141 IESRISRFQF HSSITGIMEK SRTSAQTLMD MLLANFLLTG SRSTVDDSAL KSLMRGKGEA1200
 1201 ASLARGALRE LETVVGLAYS LGVKCPIHIW AGLPISFDRA SNGGIVWQMT ADLKPNRSGH1260
 1261 PSVLAIGERY DSMLHEFQKQ AQKFNPAMPA RGVLSGAGLT FSLDKLVAAV GVEYAKDCRA1320
 1321 IDVGICVCGT RPPLKDVTYI MRLLWSVGIR CGIVEAASEL GDEAQDLARL GALHVILVAE1380
 1381 NGSLRVRSFE RERFQERHLT RTELVEFIQK MLRSDGLNGT TVDNFSQLSA LGSGDNRSSG1440
 1441 GKERERGENG LSTSASNATI KNNYSQLPNL QVTFLTHDKP TANYKRRLEN QVAQQMSSTL1500
 1501 SQFLKKETFV VLVVELPPAV VNAIVGAINP REIRKRETEP EINYVIERFS KYKRYISEIN1560
 1561 EEVVDYLSDA KTPIVALYSI SDSYYRVII

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..203] PSI-BLAST 30.39794 Solution structure of the RWD domain of mouse GCN2
    2 View Details [204..513] PSI-BLAST 53.221849 Aurora-2 T287D T288D complexed with PNU-680632
    3 View Details [514..621] FFAS03 5.05 No description for 2javA was found.
    4 View Details [622..947] PSI-BLAST 46.154902 Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form.
    5 View Details [948..1416] PSI-BLAST 97.09691 Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS)
    6 View Details [1417..1589] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity
    		•  5.77046276233401 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  3.60509600161221 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  3.38582942748827 bayes_pls_golite062009
  • eukaryotic translation initiation factor 2alpha kinase activity
    		•  3.23512529981344 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  2.64432367474615 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  2.4573066461497 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  2.4573066461497 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  2.44492491338365 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.80913854002449 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.73509739558026 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.69002970237151 bayes_pls_golite062009
  • kinase activity
    		•  1.63748693386705 bayes_pls_golite062009
  • DNA binding
    		•  1.62386281000792 bayes_pls_golite062009
  • protein kinase activity
    		•  1.53616480503563 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.47781099411385 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.26796334500099 bayes_pls_golite062009
  • transferase activity
    		•  1.12000675735902 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.972449791105909 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • protein binding
    		•  0.726328463755484 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  0.0114094023032139 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  6.0520403280225 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  6.0520403280225 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  6.04138870254626 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  5.91343220471745 bayes_pls_golite062009
  • ligase activity
    		•  4.85905957427768 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  3.22631630581238 bayes_pls_golite062009
  • proline-tRNA ligase activity
    		•  3.10945929267718 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • binding
    		•  1.93705224059718 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67362693618722 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.48056625237411 bayes_pls_golite062009
  • DNA binding
    		•  1.44496421928708 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.43493514551266 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.04999062524923 bayes_pls_golite062009
  • transferase activity
    		•  1.00944766864901 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • catalytic activity
    		•  0.902495165806215 bayes_pls_golite062009
  • transcription factor activity
    		•  0.825973629967327 bayes_pls_golite062009
  • ATP binding
    		•  0.78849239804069 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.751370849162632 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.727917585848449 bayes_pls_golite062009
  • RNA binding
    		•  0.576453255038334 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.482944943143156 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.48293725802639 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.467088940808932 bayes_pls_golite062009
  • protein binding
    		•  0.458389541110755 bayes_pls_golite062009
  • nucleotide binding
    		•  0.457991109108443 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle