| Protein: | Gcn2-PA, FBpp0306618 |
| Organism: | Drosophila melanogaster |
| Length: | 1589 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Gcn2-PA, FBpp0306618.
| Description | E-value | Query Range |
Subject Range |
|
|
993.0 | [0..1] | [1589..1] |
|
Region A: Residues: [1-203] |
1 11 21 31 41 51
| | | | | |
1 MADEKAKESF RERQAQELEV IKSIFGCDVE DLRPQANPSL WKPTDIRIQL TPLRDSSNGL 60
61 ETYVCTKLHV TCPSKYPKLP PKISLEESKG MSDQLLEALR NQLQAQSQEL RGEVMIYELA 120
121 QTVQAFLLEH NKPPKGSFYD QMLQDKQKRD QELQDIQRQR ESLQRQTLID EVERRKEMFK 180
181 TEAKRRGEPR RSMSESNPRH PSS
|
| Detection Method: |  |
| Confidence: | 30.39794 |
| Match: | 1ukxA |
| Description: | Solution structure of the RWD domain of mouse GCN2 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ligase activity | 5.77046276233401 | bayes_pls_golite062009 |
| small conjugating protein ligase activity | 3.60509600161221 | bayes_pls_golite062009 |
| ubiquitin-protein ligase activity | 3.38582942748827 | bayes_pls_golite062009 |
| eukaryotic translation initiation factor 2alpha kinase activity | 3.23512529981344 | bayes_pls_golite062009 |
| acid-amino acid ligase activity | 2.64432367474615 | bayes_pls_golite062009 |
| ligase activity, forming aminoacyl-tRNA and related compounds | 2.4573066461497 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 2.4573066461497 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 2.44492491338365 | bayes_pls_golite062009 |
| transcription regulator activity | 1.80913854002449 | bayes_pls_golite062009 |
| binding | 1.75350658654805 | bayes_pls_golite062009 |
| nucleic acid binding | 1.73509739558026 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.69002970237151 | bayes_pls_golite062009 |
| kinase activity | 1.63748693386705 | bayes_pls_golite062009 |
| DNA binding | 1.62386281000792 | bayes_pls_golite062009 |
| protein kinase activity | 1.53616480503563 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.47781099411385 | bayes_pls_golite062009 |
| transcription repressor activity | 1.26796334500099 | bayes_pls_golite062009 |
| transferase activity | 1.12000675735902 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.972449791105909 | bayes_pls_golite062009 |
| catalytic activity | 0.891402822028799 | bayes_pls_golite062009 |
| protein binding | 0.726328463755484 | bayes_pls_golite062009 |
| ligase activity, forming carbon-nitrogen bonds | 0.0114094023032139 | bayes_pls_golite062009 |
|
Region A: Residues: [204-513] |
1 11 21 31 41 51
| | | | | |
1 SESSENSSPY YRGHIYPSKC LDHRNTETLY FHKMGRQIQR GCCVGHSQRG CIAYTGIDMH 60
61 CGQLLYITEW NIKYSQLEQP CIGGGKCHWS SESKCMGSHR VDEVMASIEK QVSSLSQLQH 120
121 KNLVSYECVL CIKRKEGLLV YLVQDFLLGT SVFSISSSLG WCMDGARMVA RGVLDALVFL 180
181 HNKGVSHSHL LDTTVFMDNT GNVRVSDFSL VPNLLELLSG AGQSSSCGDL PALGALVESL 240
241 MPTNSYEMRD FVDKCNSDRT LSASELLEHP FLRFYVDNGQ QQVMPLPQQQ HPNTVQRTGS 300
301 AMPYQIPTLA
|
| Detection Method: | |
| Confidence: | 53.221849 |
| Match: | 2bmcA |
| Description: | Aurora-2 T287D T288D complexed with PNU-680632 |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [514-621] |
1 11 21 31 41 51
| | | | | |
1 LSQSRLRTEF EVLMYLGKGA FGDVLKVRNI LDNREYAIKR IPLPARSRQL YKKMTREVEL 60
61 LSRLNHENVV RYFNSWIESV DDADAAEMDK LLGGEWSQSQ QDLSVKPA
|
| Detection Method: | |
| Confidence: | 5.05 |
| Match: | 2javA |
| Description: | No description for 2javA was found. |
|
Region A: Residues: [622-947] |
1 11 21 31 41 51
| | | | | |
1 KSPQLGPTLE EDEDEEDSSS SMWNGYIPNM EDSDSDGIEF VDSNGKVAVY DDEEQEDSTR 60
61 GKTNSPKPLM QVMYIQMEFC EKCTLRTAID DNLFNDTDRL WRLFREIAEG LAHIHQQGII 120
121 HRDLKPVNIF LDSHDQIKIG DFGLATTSFL ALQAHDAAPA PVNQITSAED GTGTGKVGTT 180
181 LYVAPELTGN ASKSVYNQKV DMYTLGIILF EMCQPPFDTS MERAQTIMAL RNVSINIPDA 240
241 MLKDPKYEKT VKMLQWLLNH DPAQRPTAEE LLISDLVPPA QLEANELQEM LRHALANPQS 300
301 KAYKNLVARC LQQESDEVLE HTYHLG
|
| Detection Method: | |
| Confidence: | 46.154902 |
| Match: | 1zy4A |
| Description: | Crystal Structure of eIF2alpha Protein Kinase GCN2: R794G Hyperactivating Mutant in Apo Form. |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [948-1416] |
1 11 21 31 41 51
| | | | | |
1 SSRAMKSWNS AIIIDDIVSL NPVIEFVKAK VVNLFRKHGA IEVDSPLLSP LSARNSTANA 60
61 NANAVHLMTH SGCVVVLPCD LRTQFARHVT MNSVNLIRRY CVDRVYREER VFNFHPKQSY 120
121 DCSFDIIAPT TGSHLVDAEL LSLAFEITSE LPRLREKNLA IRMNHTNLLR AILIFCNVPK 180
181 AQYGALFEGT MDFIESRISR FQFHSSITGI MEKSRTSAQT LMDMLLANFL LTGSRSTVDD 240
241 SALKSLMRGK GEAASLARGA LRELETVVGL AYSLGVKCPI HIWAGLPISF DRASNGGIVW 300
301 QMTADLKPNR SGHPSVLAIG ERYDSMLHEF QKQAQKFNPA MPARGVLSGA GLTFSLDKLV 360
361 AAVGVEYAKD CRAIDVGICV CGTRPPLKDV TYIMRLLWSV GIRCGIVEAA SELGDEAQDL 420
421 ARLGALHVIL VAENGSLRVR SFERERFQER HLTRTELVEF IQKMLRSDG
|
| Detection Method: | |
| Confidence: | 97.09691 |
| Match: | 1kmmA |
| Description: | Histidyl-tRNA synthetase (HisRS), C-terminal domain; Histidyl-tRNA synthetase (HisRS) |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| ligase activity, forming aminoacyl-tRNA and related compounds | 6.0520403280225 | bayes_pls_golite062009 |
| ligase activity, forming carbon-oxygen bonds | 6.0520403280225 | bayes_pls_golite062009 |
| aminoacyl-tRNA ligase activity | 6.04138870254626 | bayes_pls_golite062009 |
| histidine-tRNA ligase activity | 5.91343220471745 | bayes_pls_golite062009 |
| ligase activity | 4.85905957427768 | bayes_pls_golite062009 |
| phenylalanine-tRNA ligase activity | 3.22631630581238 | bayes_pls_golite062009 |
| proline-tRNA ligase activity | 3.10945929267718 | bayes_pls_golite062009 |
| serine-tRNA ligase activity | 2.46505535069103 | bayes_pls_golite062009 |
| glycine-tRNA ligase activity | 2.29229136935761 | bayes_pls_golite062009 |
| threonine-tRNA ligase activity | 2.18642354927 | bayes_pls_golite062009 |
| binding | 1.93705224059718 | bayes_pls_golite062009 |
| alanine-tRNA ligase activity | 1.82594054955281 | bayes_pls_golite062009 |
| lysine-tRNA ligase activity | 1.72324031407565 | bayes_pls_golite062009 |
| transcription regulator activity | 1.67362693618722 | bayes_pls_golite062009 |
| nucleic acid binding | 1.48056625237411 | bayes_pls_golite062009 |
| DNA binding | 1.44496421928708 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.43493514551266 | bayes_pls_golite062009 |
| transcription repressor activity | 1.04999062524923 | bayes_pls_golite062009 |
| transferase activity | 1.00944766864901 | bayes_pls_golite062009 |
| asparagine-tRNA ligase activity | 0.921492123574877 | bayes_pls_golite062009 |
| catalytic activity | 0.902495165806215 | bayes_pls_golite062009 |
| transcription factor activity | 0.825973629967327 | bayes_pls_golite062009 |
| ATP binding | 0.78849239804069 | bayes_pls_golite062009 |
| adenyl ribonucleotide binding | 0.751370849162632 | bayes_pls_golite062009 |
| adenyl nucleotide binding | 0.727917585848449 | bayes_pls_golite062009 |
| RNA binding | 0.576453255038334 | bayes_pls_golite062009 |
| purine ribonucleotide binding | 0.482944943143156 | bayes_pls_golite062009 |
| ribonucleotide binding | 0.48293725802639 | bayes_pls_golite062009 |
| purine nucleotide binding | 0.467088940808932 | bayes_pls_golite062009 |
| protein binding | 0.458389541110755 | bayes_pls_golite062009 |
| nucleotide binding | 0.457991109108443 | bayes_pls_golite062009 |
| aspartate-tRNA ligase activity | 0.00572514744734753 | bayes_pls_golite062009 |
|
Region A: Residues: [1417-1589] |
1 11 21 31 41 51
| | | | | |
1 LNGTTVDNFS QLSALGSGDN RSSGGKERER GENGLSTSAS NATIKNNYSQ LPNLQVTFLT 60
61 HDKPTANYKR RLENQVAQQM SSTLSQFLKK ETFVVLVVEL PPAVVNAIVG AINPREIRKR 120
121 ETEPEINYVI ERFSKYKRYI SEINEEVVDY LSDAKTPIVA LYSISDSYYR VII
|
| Detection Method: | |
Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
