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Protein Overview: wts-PA

General Information:
Name(s) found: wts-PA / FBpp0085082 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene warts is referred to in FlyBase by the symbol Dmel\wts (CG12072, FBgn0011739). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26615379..26632341. It has the cytological map location 100A5. There is experimental evidence that it has the molecular function</span>: protein binding; specific transcriptional repressor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; regulation of dendrite morphogenesis; compound eye development; cellular process; G1/S transition of mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to ionizing radiation; R8 cell fate specification; negative regulation of cell proliferation; imaginal disc growth. 103 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: external compound sense organ; nervous system; peripheral nervous system; organ system; compound cell cluster organ; imaginal precursor; larval imaginal precursor; developing anatomical structure; adult segment; adult mesothoracic segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1105 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of cell shape [IMP]
    negative regulation of cell proliferation [IMP][TAS]
    DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis [IGI]
    terminal branching, open tracheal system [NAS]
    negative regulation of organ growth [TAS]
    protein amino acid phosphorylation [IEA][NAS]
    compound eye development [IMP]
    regulation of cell proliferation [TAS]
    cellular process [IMP]
    regulation of dendrite morphogenesis [IGI]
    imaginal disc growth [IMP]
    regulation of imaginal disc growth [TAS]
    R8 cell fate specification [IMP]
    G1/S transition of mitotic cell cycle [IMP]
    response to ionizing radiation [IMP]
    Molecular Function: ATP binding [IEA]
    protein binding [IPI][TAS]
    protein serine/threonine kinase activity [IEA][ISS][NAS]
    specific transcriptional repressor activity [IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHPAGEKRGG RPNDKYTAEA LESIKQDLTR FEVQNNHRNN QNYTPLRYTA TNGRNDALTP  60
   61 DYHHAKQPME PPPSASPAPD VVIPPPPAIV GQPGAGSISV SGVGVGVVGV ANGRVPKMMT 120
  121 ALMPNKLIRK PSIERDTASS HYLRCSPALD SGAGSSRSDS PHSHHTHQPS SRTVGNPGGN 180
  181 GGFSPSPSGF SEVAPPAPPP RNPTACSAAT PPPPVPPTSQ AYVKRRSPAL NNRPPAIAPP 240
  241 TQRGNSPVIT QNGLKNPQQQ LTQQLKSLNL YPGGGSGAVV EPPPPYLIQG GAGGAAPPPP 300
  301 PPSYTASMQS RQSPTQSQQS DYRKSPSSGI YSATSAGSPS PITVSLPPAP LAKPQPRVYQ 360
  361 ARSQQPIIMQ SVKSTQVQKP VLQTAVAPQS PSSASASNSP VHVLAAPPSY PQKSAAVVQQ 420
  421 QQQAAAAAHQ QQHQHQQSKP PTPTTPPLVG LNSKPNCLEP PSYAKSMQAK AATVVQQQQQ 480
  481 QQQQQQQVQQ QQVQQQQQQQ QQQLQALRVL QAQAQRERDQ RERDQRERER DQQKLANGNP 540
  541 GRQMLPPPPY QSNNNNNSEI KPPSCNNNNI QISNSNLATT PPIPPAKYNN NSSNTGANSS 600
  601 GGSNGSTGTT ASSSTSCKKI KHASPIPERK KISKEKEEER KEFRIRQYSP QAFKFFMEQH 660
  661 IENVIKSYRQ RTYRKNQLEK EMHKVGLPDQ TQIEMRKMLN QKESNYIRLK RAKMDKSMFV 720
  721 KLKPIGVGAF GEVTLVSKID TSNHLYAMKT LRKADVLKRN QVAHVKAERD ILAEADNNWV 780
  781 VKLYYSFQDK DNLYFVMDYI PGGDLMSLLI KLGIFEEELA RFYIAEVTCA VDSVHKMGFI 840
  841 HRDIKPDNIL IDRDGHIKLT DFGLCTGFRW THNSKYYQEN GNHSRQDSME PWEEYSENGP 900
  901 KPTVLERRRM RDHQRVLAHS LVGTPNYIAP EVLERSGYTQ LCDYWSVGVI LYEMLVGQPP 960
  961 FLANSPLETQ QKVINWEKTL HIPPQAELSR EATDLIRRLC ASADKRLGKS VDEVKSHDFF1020
 1021 KGIDFADMRK QKAPYIPEIK HPTDTSNFDP VDPEKLRSND STMSSGDDVD QNDRTFHGFF1080
 1081 EFTFRRFFDD KQPPDMTDDQ APVYV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] MSA 3.201995 View MSA. No confident structure predictions are available.
    2 View Details [143..337] MSA 5.278996 View MSA. No confident structure predictions are available.
    3 View Details [338..569] deduced N/A No confident structure predictions are available.
    4 View Details [570..631] deduced N/A No confident structure predictions are available.
    5 View Details [632..1105] PSI-BLAST 82.522879 Crystal Structure of ROCK 1 bound to fasudil


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle