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Protein Overview: zfh1-PB

General Information:
Name(s) found: zfh1-PB / FBpp0085063 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Zn finger homeodomain 1 is referred to in FlyBase by the symbol Dmel\zfh1 (CG1322, FBgn0004606). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26591648..26612899. It has the cytological map location 100A4-100A5. Based on sequence similarity, it is predicted to have molecular function</span>: RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: motor axon guidance; nervous system development; antimicrobial humoral response; germ cell migration; garland cell differentiation; lymph gland development; mesoderm development. 34 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: organ system; anatomical structure; circulatory system; late extended germ band embryo; multi-cell-component structure; primordium; embryonic/larval dorsal vessel; developing anatomical structure; peripheral nervous system; embryonic/larval hypodermal muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1054 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: pole cell migration [TAS]
    motor axon guidance [IMP]
    nervous system development [IEP]
    mesoderm development [IEP][IGI][NAS]
    regulation of transcription, DNA-dependent [IEA]
    germ cell migration [IMP][TAS]
    regulation of transcription [IEA]
    garland cell differentiation [IMP]
    muscle organ development [NAS]
    heart development [NAS]
    gonad development [TAS]
    central nervous system development [NAS]
    lymph gland development [IMP]
    antimicrobial humoral response [IMP]
    Molecular Function: DNA binding [TAS]
    transcription factor activity [IEA]
    zinc ion binding [IEA]
    RNA polymerase II transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSCLAPSSS RFGQEDTIIQ QSMPSTSPFA MQFPSLASTL LHHNQSPKHS NPGSSGIQDA  60
   61 HPNQPGAAAD AFLVKCTQCH KRFPEYQSLS EHIASEHPHD KLNCGAAQPE SDAEDEQSNM 120
  121 SGSSRRYAKS PLASNNNSST ANANNNSTSS QSMNNNSELA KNHNSANKMS PMCSPGSLTP 180
  181 GDLFAQLQHP PPQLPPHLHA QFMAAAASLA MQSARTASSP SQQQQQQLQQ QQQLQQQQQH 240
  241 QMAMQQLLPP QLPGSNSSVG SNSAYDLDLS APRSTSSPGS TTGDLSGAYP CMQCTASFAS 300
  301 REQLEQHEQL HSPCGPAAVS NVSQTCRICH KAFANVYRLQ RHMISHDESA LLRKFKCKEC 360
  361 DKAFKFKHHL KEHVRIHSGE KPFGCDNCGK RFSHSGSFSS HMTSKKCISM GLKLNNNRAL 420
  421 LKRLEKSPGS ASSASRRSPS DHGKGKLPEQ PSLPGLPHPM SYFASDAQVQ GGSAAPAPFP 480
  481 PFHPNYMNAA LLAFPHNFMA AAAGLDPRVH PYSIQRLLQL SAAGQQQREE EREEQQKQQQ 540
  541 HDEEETPDEP KLVMDIEEPE TKEMAPTPEA TEAATPIKRE ESREASPDPE SYRSSSQAIK 600
  601 QEQEPLNVAE ERQTPVEEHA PVEHAADLRC SRCSKQFNHP TELVQHEKVL CGLIKEELEQ 660
  661 HFQQQQATSF ALASASEEDE EDEEMDVEEE PRQESGERKV RVRTAINEEQ QQQLKQHYSL 720
  721 NARPSRDEFR MIAARLQLDP RVVQVWFQNN RSRERKMQSF QNNQAAGAAP PMPIDSQASL 780
  781 TREDQPLDLS VKRDPLTPKS ESSPPYIAPP SGEALNPEAI NLSRKFSTSA SMSPASISPS 840
  841 SAAALYFGAA PPPSPPNSQL DSTPRSGQAF PGLPPYMLPM SLPMEALFKM RPGGDFASNH 900
  901 ALMNSIKLPD YRGTSLSPGG SEKRSWRDDD SRISHEDEFG AGVLMPPKPR RGKAETHGHA 960
  961 GDPDLPYVCD QCDKAFAKQS SLARHKYEHS GQRPYQCIEC PKAFKHKHHL TEHKRLHSGE1020
 1021 KPFQCSKCLK RFSHSGSYSQ HMNHRYSYCK PYRE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] FFAS03 5.83 No description for 2i13A was found.
    2 View Details [351..455] PSI-BLAST 4.522879 THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION
    3 View Details [456..583] MSA 1.284996 View MSA. No confident structure predictions are available.
    4 View Details [584..667] deduced N/A No confident structure predictions are available.
    5 View Details [668..803] FFAS03 3.56 TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
    6 View Details [804..881] deduced N/A No confident structure predictions are available.
    7 View Details [882..1054] PSI-BLAST 58.69897 No description for 2i13A was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • binding
    		•  2.77786931095369 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.55586552794761 bayes_pls_golite062009
  • DNA binding
    		•  2.44956708063674 bayes_pls_golite062009
  • transcription factor activity
    		•  2.02834241432042 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.70881974574823 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.55892000506547 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.20814417016896 bayes_pls_golite062009
  • protein binding
    		•  0.818425640290782 bayes_pls_golite062009
  • transcription activator activity
    		•  0.63470910630708 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.554672261723419 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  0.290438006244452 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0689075518148576 bayes_pls_golite062009
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle