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View Structure Prediction Details

Protein: zfh1-PB
Organism: Drosophila melanogaster
Length: 1054 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for zfh1-PB.

Description E-value Query
Range
Subject
Range
gi|109458488 - gi|109458488|ref|XP_574414.2| PREDICTED: similar to Zinc finger protein 208 [Rattus norvegicus]
1202.0 [0..3] [1052..308]

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Predicted Domain #1
Region A:
Residues: [1-350]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSCLAPSSS RFGQEDTIIQ QSMPSTSPFA MQFPSLASTL LHHNQSPKHS NPGSSGIQDA  60
   61 HPNQPGAAAD AFLVKCTQCH KRFPEYQSLS EHIASEHPHD KLNCGAAQPE SDAEDEQSNM 120
  121 SGSSRRYAKS PLASNNNSST ANANNNSTSS QSMNNNSELA KNHNSANKMS PMCSPGSLTP 180
  181 GDLFAQLQHP PPQLPPHLHA QFMAAAASLA MQSARTASSP SQQQQQQLQQ QQQLQQQQQH 240
  241 QMAMQQLLPP QLPGSNSSVG SNSAYDLDLS APRSTSSPGS TTGDLSGAYP CMQCTASFAS 300
  301 REQLEQHEQL HSPCGPAAVS NVSQTCRICH KAFANVYRLQ RHMISHDESA 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 5.83
Match: 2i13A
Description: No description for 2i13A was found.

Predicted Domain #2
Region A:
Residues: [351-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLRKFKCKEC DKAFKFKHHL KEHVRIHSGE KPFGCDNCGK RFSHSGSFSS HMTSKKCISM  60
   61 GLKLNNNRAL LKRLEKSPGS ASSASRRSPS DHGKGKLPEQ PSLPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.522879
Match: 1un6B
Description: THE CRYSTAL STRUCTURE OF A ZINC FINGER - RNA COMPLEX REVEALS TWO MODES OF MOLECULAR RECOGNITION
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [456-583]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPHPMSYFAS DAQVQGGSAA PAPFPPFHPN YMNAALLAFP HNFMAAAAGL DPRVHPYSIQ  60
   61 RLLQLSAAGQ QQREEEREEQ QKQQQHDEEE TPDEPKLVMD IEEPETKEMA PTPEATEAAT 120
  121 PIKREESR

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [584-667]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EASPDPESYR SSSQAIKQEQ EPLNVAEERQ TPVEEHAPVE HAADLRCSRC SKQFNHPTEL  60
   61 VQHEKVLCGL IKEELEQHFQ QQQA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [668-803]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TSFALASASE EDEEDEEMDV EEEPRQESGE RKVRVRTAIN EEQQQQLKQH YSLNARPSRD  60
   61 EFRMIAARLQ LDPRVVQVWF QNNRSRERKM QSFQNNQAAG AAPPMPIDSQ ASLTREDQPL 120
  121 DLSVKRDPLT PKSESS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.56
Match: 1o4xA
Description: TERNARY COMPLEX OF THE DNA BINDING DOMAINS OF THE OCT1 AND SOX2 TRANSCRIPTION FACTORS WITH A 19MER OLIGONUCLEOTIDE FROM THE HOXB1 REGULATORY ELEMENT
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.77786931095369 bayes_pls_golite062009
transcription regulator activity 2.55586552794761 bayes_pls_golite062009
DNA binding 2.44956708063674 bayes_pls_golite062009
transcription factor activity 2.02834241432042 bayes_pls_golite062009
nucleic acid binding 1.70881974574823 bayes_pls_golite062009
sequence-specific DNA binding 1.55892000506547 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.20814417016896 bayes_pls_golite062009
protein binding 0.818425640290782 bayes_pls_golite062009
transcription activator activity 0.63470910630708 bayes_pls_golite062009
transcription repressor activity 0.554672261723419 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 0.290438006244452 bayes_pls_golite062009
transcription factor binding 0.0689075518148576 bayes_pls_golite062009

Predicted Domain #6
Region A:
Residues: [804-881]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPYIAPPSGE ALNPEAINLS RKFSTSASMS PASISPSSAA ALYFGAAPPP SPPNSQLDST  60
   61 PRSGQAFPGL PPYMLPMS

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [882-1054]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPMEALFKMR PGGDFASNHA LMNSIKLPDY RGTSLSPGGS EKRSWRDDDS RISHEDEFGA  60
   61 GVLMPPKPRR GKAETHGHAG DPDLPYVCDQ CDKAFAKQSS LARHKYEHSG QRPYQCIECP 120
  121 KAFKHKHHLT EHKRLHSGEK PFQCSKCLKR FSHSGSYSQH MNHRYSYCKP YRE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 58.69897
Match: 2i13A
Description: No description for 2i13A was found.

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