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Protein Overview: aralar1-PC

General Information:
Name(s) found: aralar1-PC / FBpp0085054 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene aralar1 is referred to in FlyBase by the symbol Dmel\aralar1 (CG2139, FBgn0028646). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26271361..26281589. It has the cytological map location 99F4-99F5. Based on sequence similarity, it is predicted to have molecular function</span>: calcium ion binding; transmembrane transporter activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mitochondrial transport. 11 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 695 amino acids

    Gene Ontology:
    Cellular Component: lipid particle [IDA]
    integral to membrane [NAS]
    mitochondrial envelope [ISS]
    mitochondrial inner membrane [ISS][NAS]
    Biological Process: transmembrane transport [IEA]
    mitochondrial transport [ISS]
    transport [NAS]
    Molecular Function: transmembrane transporter activity [ISS][NAS]
    calcium ion binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMHIPFPFN WIPTLPVARC QESPSLLKRA GTEKLREVFL KYASIQKNGE HYMTSEDFVR  60
   61 KFLGLFSESA FNDESVRLLA NIADTSKDGL ISFSEFQAFE GLLCTPDALY RTAFQLFDRK 120
  121 GNGTVSYADF ADVVQKTELH SKIPFSLDGP FIKRYFGDKK QRLINYAEFT QLLHDFHEEH 180
  181 AMEAFRSKDP AGTGFISPLD FQDIIVNVKR HLLTPGVRDN LVSVTEGHKV SFPYFIAFTS 240
  241 LLNNMELIKQ VYLHATEGSR TDMITKDQIL LAAQTMSQIT PLEIDILFHL AGAVHQAGRI 300
  301 DYSDLSNIAP EHYTKHMTHR LAEIKAVESP ADRSAFIQVL ESSYRFTLGS FAGAVGATVV 360
  361 YPIDLVKTRM QNQRAGSYIG EVAYRNSWDC FKKVVRHEGF MGLYRGLLPQ LMGVAPEKAI 420
  421 KLTVNDLVRD KLTDKKGNIP TWAEVLAGGC AGASQVVFTN PLEIVKIRLQ VAGEIASGSK 480
  481 IRAWSVVREL GLFGLYKGAR ACLLRDVPFS AIYFPTYAHT KAMMADKDGY NHPLTLLAAG 540
  541 AIAGVPAASL VTPADVIKTR LQVVARSGQT TYTGVWDATK KIMAEEGPRA FWKGTAARVF 600
  601 RSSPQFGVTL VTYELLQRLF YVDFGGTQPK GSEAHKITTP LEQAAASVTT ENVDHIGGYR 660
  661 AAVPLLAGVE SKFGLYLPRF GRGVTAASPS TATGS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] PSI-BLAST 41.522879 No description for 1zuzA was found.
    2 View Details [175..335] FFAS03 4.36 Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
    3 View Details [336..695] PSI-BLAST 77.154902 structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • calcium ion binding
    		•  3.79609619542776 bayes_pls_golite062009
  • binding
    		•  2.74623080162785 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.61874575467092 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.59226289545114 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.57032504567157 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.55650624542181 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.37465721152046 bayes_pls_golite062009
  • structural molecule activity
    		•  2.02132683356917 bayes_pls_golite062009
  • potassium channel activity
    		•  1.89948827776974 bayes_pls_golite062009
  • motor activity
    		•  1.81368053536929 bayes_pls_golite062009
  • voltage-gated potassium channel activity
    		•  1.81135503818602 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.6840107470242 bayes_pls_golite062009
  • actin binding
    		•  1.50831300191117 bayes_pls_golite062009
  • cation channel activity
    		•  1.49312394054212 bayes_pls_golite062009
  • signal transducer activity
    		•  1.38521870126745 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.38521870126745 bayes_pls_golite062009
  • ion binding
    		•  1.36376383271837 bayes_pls_golite062009
  • metal ion binding
    		•  1.34827363853601 bayes_pls_golite062009
  • cation binding
    		•  1.34827363853601 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.22886396511326 bayes_pls_golite062009
  • protein binding
    		•  1.16246005294206 bayes_pls_golite062009
  • transporter activity
    		•  1.15928534291452 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.0725773039399 bayes_pls_golite062009
  • channel activity
    		•  1.05847414989139 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.05847414989139 bayes_pls_golite062009
  • ion channel activity
    		•  1.0369591011376 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.03529144716694 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  0.986621437232479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.945691505472547 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  0.910148857310729 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  0.896351900356978 bayes_pls_golite062009
  • gated channel activity
    		•  0.855502499003241 bayes_pls_golite062009
  • tubulin binding
    		•  0.851404549871251 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.849623084382492 bayes_pls_golite062009
  • actin-dependent ATPase activity
    		•  0.83859958498483 bayes_pls_golite062009
  • DNA binding
    		•  0.81633153359201 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  0.717054504236607 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.693724160233023 bayes_pls_golite062009
  • microtubule binding
    		•  0.482216984478791 bayes_pls_golite062009
  • myosin binding
    		•  0.41761909113528 bayes_pls_golite062009
    		• 0.34446792626966 bayes_pls_golite062009
  • channel regulator activity
    		•  0.32809521759917 bayes_pls_golite062009
  • protein complex binding
    		•  0.278602833762221 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.246383459363256 bayes_pls_golite062009
  • myosin heavy chain binding
    		•  0.15875878144391 bayes_pls_golite062009
  • G-protein beta/gamma-subunit binding
    		•  0.13723868253862 bayes_pls_golite062009
  • transcription factor binding
    		•  0.02456682442567 bayes_pls_golite062009
  • actin filament binding
    		•  0.0239092123185181 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.59

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle