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Protein Overview: trp-PA

General Information:
Name(s) found: trp-PA / FBpp0084879 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene transient receptor potential is referred to in FlyBase by the symbol Dmel\trp (CG7875, FBgn0003861). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25740242..25746011. It has the cytological map location 99C6-99C7. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: light-induced release of internally sequestered calcium ion; olfactory learning; protein localization; detection of light stimulus involved in visual perception; response to light stimulus; detection of light stimulus involved in sensory perception; inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway. 42 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor; rhabdomere; retina; antenna; photoreceptor cell; eye photoreceptor cell; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1275 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [NAS]
    light-activated voltage-gated calcium channel complex [NAS]
    integral to membrane [IEA]
    inaD signaling complex [IPI][TAS]
    rhabdomere [IDA][NAS][TAS]
    Biological Process: detection of light stimulus involved in visual perception [IMP]
    transmembrane transport [IEA]
    inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway [IMP]
    calcium ion transport [ISS]
    protein localization [IMP]
    light-induced release of internally sequestered calcium ion [IDA]
    olfactory learning [IMP]
    calcium-mediated signaling [TAS]
    response to light stimulus [IMP][TAS]
    phototransduction [NAS]
    detection of light stimulus involved in sensory perception [IMP]
    Molecular Function: store-operated calcium channel activity [NAS][TAS]
    calmodulin binding [TAS]
    intracellular ligand-gated calcium channel activity [NAS]
    protein binding [IPI]
    calcium channel activity [ISS]
    light-activated voltage-gated calcium channel activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSNTESDAE KALGSRLDYD LMMAEEYILS DVEKNFILSC ERGDLPGVKK ILEEYQGTDK  60
   61 FNINCTDPMN RSALISAIEN ENFDLMVILL EHNIEVGDAL LHAISEEYVE AVEELLQWEE 120
  121 TNHKEGQPYS WEAVDRSKST FTVDITPLIL AAHRNNYEIL KILLDRGATL PMPHDVKCGC 180
  181 DECVTSQMTD SLRHSQSRIN AYRALSASSL IALSSRDPVL TAFQLSWELK RLQAMESEFR 240
  241 AEYTEMRQMV QDFGTSLLDH ARTSMELEVM LNFNHEPSHD IWCLGQRQTL ERLKLAIRYK 300
  301 QKTFVAHPNV QQLLAAIWYD GLPGFRRKQA SQQLMDVVKL GCSFPIYSLK YILAPDSEGA 360
  361 KFMRKPFVKF ITHSCSYMFF LMLLGAASLR VVQITFELLA FPWMLTMLED WRKHERGSLP 420
  421 GPIELAIITY IMALIFEELK SLYSDGLFEY IMDLWNIVDY ISNMFYVTWI LCRATAWVIV 480
  481 HRDLWFRGID PYFPREHWHP FDPMLLSEGA FAAGMVFSYL KLVHIFSINP HLGPLQVSLG 540
  541 RMIIDIIKFF FIYTLVLFAF GCGLNQLLWY YAELEKNKCY HLHPDVADFD DQEKACTIWR 600
  601 RFSNLFETSQ SLFWASFGLV DLVSFDLAGI KSFTRFWALL MFGSYSVINI IVLLNMLIAM 660
  661 MSNSYQIISE RADTEWKFAR SQLWMSYFED GGTIPPPFNL CPNMKMLRKT LGRKRPSRTK 720
  721 SFMRKSMERA QTLHDKVMKL LVRRYITAEQ RRRDDYGITE DDIIEVRQDI SSLRFELLEI 780
  781 FTNNNWDVPD IEKKSQGVAR TTKGKVMERR ILKDFQIGFV ENLKQEMSES ESGRDIFSSL 840
  841 AKVIGRKKTQ KGDKDWNAIA RKNTFASDPI GSKRSSMQRH SQRSLRRKII EQANEGLQMN 900
  901 QTQLIEFNPN LGDVTRATRV AYVKFMRKKM AADEVSLADD EGAPNGEGEK KPLDASGSKK 960
  961 SITSGGTGGG ASMLAAAALR ASVKNVDEKS GADGKPGTMG KPTDDKKAGD DKDKQQPPKD1020
 1021 SKPSAGGPKP GDQKPTPGAG APKPQAAGTI SKPGESQKKD APAPPTKPGD TKPAAPKPGE1080
 1081 SAKPEAAAKK EESSKTEASK PAATNGAAKS AAPSAPSDAK PDSKLKPGAA GAPEATKATN1140
 1141 GASKPDEKKS GPEEPKKAAG DSKPGDDAKD KDKKPGDDKD KKPGDDKDKK PADNNDKKPA1200
 1201 DDKDKKPGDD KDKKPGDDKD KKPSDDKDKK PADDKDKKPA AAPLKPAIKV GQSSAAAGGE1260
 1261 RGKSTVTGRM ISGWL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..325] PSI-BLAST 34.221849 Ankyrin-R
    2 View Details [326..756] FFAS03 2.57 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    3 View Details [757..1275] PSI-BLAST 54.69897 No description for 1y0fA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • calcium channel activity
    		•  7.22916731810254 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.98552435559384 bayes_pls_golite062009
  • cation channel activity
    		•  6.50474084096758 bayes_pls_golite062009
  • ion channel activity
    		•  6.39395185707074 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  6.33572754054424 bayes_pls_golite062009
  • channel activity
    		•  6.33572754054424 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  6.1768489311098 bayes_pls_golite062009
  • gated channel activity
    		•  5.72409430487316 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  2.98642849222395 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  2.98642849222395 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.89029061890648 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.66479899929908 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.59441577402651 bayes_pls_golite062009
  • binding
    		•  1.96927469603571 bayes_pls_golite062009
  • receptor activity
    		•  1.79819694205385 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.70456609903044 bayes_pls_golite062009
  • signal transducer activity
    		•  1.68903441797843 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.68903441797843 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.64895183402675 bayes_pls_golite062009
  • protein binding
    		•  1.64872738860757 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.835937200249181 bayes_pls_golite062009
  • peptide binding
    		•  0.656909637959496 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.645199153849127 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.645199153849127 bayes_pls_golite062009
  • enzyme binding
    		•  0.60140077251711 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.45950244714772 bayes_pls_golite062009
  • protein kinase binding
    		•  0.20030215426972 bayes_pls_golite062009
  • kinase binding
    		•  0.19731595055292 bayes_pls_golite062009
  • receptor binding
    		•  0.11089495579447 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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