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View Structure Prediction Details

Protein: trp-PA
Organism: Drosophila melanogaster
Length: 1275 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for trp-PA.

Description E-value Query
Range		 Subject
Range
gi|85171 - gi|85171|pir||JU0092 trp protein - fruit fly (Drosophila melanogaster)
 1066.0 [0..1] [1155..1]

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Predicted Domain #1
Region A:
Residues: [1-325] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSNTESDAE KALGSRLDYD LMMAEEYILS DVEKNFILSC ERGDLPGVKK ILEEYQGTDK  60
   61 FNINCTDPMN RSALISAIEN ENFDLMVILL EHNIEVGDAL LHAISEEYVE AVEELLQWEE 120
  121 TNHKEGQPYS WEAVDRSKST FTVDITPLIL AAHRNNYEIL KILLDRGATL PMPHDVKCGC 180
  181 DECVTSQMTD SLRHSQSRIN AYRALSASSL IALSSRDPVL TAFQLSWELK RLQAMESEFR 240
  241 AEYTEMRQMV QDFGTSLLDH ARTSMELEVM LNFNHEPSHD IWCLGQRQTL ERLKLAIRYK 300
  301 QKTFVAHPNV QQLLAAIWYD GLPGF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 34.221849
Match: 1n11A
Description: Ankyrin-R
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
calcium channel activity 7.22916731810254 bayes_pls_golite062009
metal ion transmembrane transporter activity 6.98552435559384 bayes_pls_golite062009
cation channel activity 6.50474084096758 bayes_pls_golite062009
ion channel activity 6.39395185707074 bayes_pls_golite062009
passive transmembrane transporter activity 6.33572754054424 bayes_pls_golite062009
channel activity 6.33572754054424 bayes_pls_golite062009
substrate-specific channel activity 6.1768489311098 bayes_pls_golite062009
gated channel activity 5.72409430487316 bayes_pls_golite062009
ligand-gated channel activity 2.98642849222395 bayes_pls_golite062009
ligand-gated ion channel activity 2.98642849222395 bayes_pls_golite062009
ion transmembrane transporter activity 2.89029061890648 bayes_pls_golite062009
cation transmembrane transporter activity 2.66479899929908 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.59441577402651 bayes_pls_golite062009
binding 1.96927469603571 bayes_pls_golite062009
receptor activity 1.79819694205385 bayes_pls_golite062009
transmembrane receptor activity 1.70456609903044 bayes_pls_golite062009
signal transducer activity 1.68903441797843 bayes_pls_golite062009
molecular transducer activity 1.68903441797843 bayes_pls_golite062009
structural constituent of muscle 1.64895183402675 bayes_pls_golite062009
protein binding 1.64872738860757 bayes_pls_golite062009
transporter activity 1.19000052859754 bayes_pls_golite062009
transmembrane transporter activity 1.02570255606772 bayes_pls_golite062009
substrate-specific transporter activity 0.835937200249181 bayes_pls_golite062009
peptide binding 0.656909637959496 bayes_pls_golite062009
mechanically-gated ion channel activity 0.645199153849127 bayes_pls_golite062009
mechanically gated channel activity 0.645199153849127 bayes_pls_golite062009
enzyme binding 0.60140077251711 bayes_pls_golite062009
cytoskeletal protein binding 0.45950244714772 bayes_pls_golite062009
protein kinase binding 0.20030215426972 bayes_pls_golite062009
kinase binding 0.19731595055292 bayes_pls_golite062009
receptor binding 0.11089495579447 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [326-756] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRKQASQQLM DVVKLGCSFP IYSLKYILAP DSEGAKFMRK PFVKFITHSC SYMFFLMLLG  60
   61 AASLRVVQIT FELLAFPWML TMLEDWRKHE RGSLPGPIEL AIITYIMALI FEELKSLYSD 120
  121 GLFEYIMDLW NIVDYISNMF YVTWILCRAT AWVIVHRDLW FRGIDPYFPR EHWHPFDPML 180
  181 LSEGAFAAGM VFSYLKLVHI FSINPHLGPL QVSLGRMIID IIKFFFIYTL VLFAFGCGLN 240
  241 QLLWYYAELE KNKCYHLHPD VADFDDQEKA CTIWRRFSNL FETSQSLFWA SFGLVDLVSF 300
  301 DLAGIKSFTR FWALLMFGSY SVINIIVLLN MLIAMMSNSY QIISERADTE WKFARSQLWM 360
  361 SYFEDGGTIP PPFNLCPNMK MLRKTLGRKR PSRTKSFMRK SMERAQTLHD KVMKLLVRRY 420
  421 ITAEQRRRDD Y

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.57
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [757-1275] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GITEDDIIEV RQDISSLRFE LLEIFTNNNW DVPDIEKKSQ GVARTTKGKV MERRILKDFQ  60
   61 IGFVENLKQE MSESESGRDI FSSLAKVIGR KKTQKGDKDW NAIARKNTFA SDPIGSKRSS 120
  121 MQRHSQRSLR RKIIEQANEG LQMNQTQLIE FNPNLGDVTR ATRVAYVKFM RKKMAADEVS 180
  181 LADDEGAPNG EGEKKPLDAS GSKKSITSGG TGGGASMLAA AALRASVKNV DEKSGADGKP 240
  241 GTMGKPTDDK KAGDDKDKQQ PPKDSKPSAG GPKPGDQKPT PGAGAPKPQA AGTISKPGES 300
  301 QKKDAPAPPT KPGDTKPAAP KPGESAKPEA AAKKEESSKT EASKPAATNG AAKSAAPSAP 360
  361 SDAKPDSKLK PGAAGAPEAT KATNGASKPD EKKSGPEEPK KAAGDSKPGD DAKDKDKKPG 420
  421 DDKDKKPGDD KDKKPADNND KKPADDKDKK PGDDKDKKPG DDKDKKPSDD KDKKPADDKD 480
  481 KKPAAAPLKP AIKVGQSSAA AGGERGKSTV TGRMISGWL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.69897
Match: 1y0fA
Description: No description for 1y0fA was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle