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Protein Overview: FBpp0306780, pll-PA

General Information:
Name(s) found: FBpp0306780 [FlyBase]
pll-PA / FBpp0084549 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=3R:complement(23077053..23077572,23077636..23078301,23078360..23078679); ID=FBpp0306780; name=pll-PB; parent=FBgn0010441,FBtr0334732; dbxref=FlyBase:FBpp0306780,FlyBase_Annotation_IDs:CG5974-PB,REFSEQ:NP_001263008,GB_protein:AGB96388; MD5=425980f8d59974252a5f7cc82c2925be; length=501; release=r5.56; species=Dmel; [FlyBase]
  • The gene pelle is referred to in FlyBase by the symbol Dmel\pll (CG5974, FBgn0010441). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:23076853..23078902. It has the cytological map location 97E11. There is experimental evidence that it has the molecular function</span>: protein domain specific binding. There is experimental evidence that it is involved in the biological process</span>: antifungal humoral response; zygotic determination of dorsal/ventral axis. 66 alleles are reported. The phenotypes of these alleles are annotated with: embryonic ventral epidermis; filzkorper; medulla; macrochaeta; embryonic posterior spiracle; embryonic/larval hemolymph; lamina; embryonic/larval somatic muscle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 501 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA][NAS]
    plasma membrane [IDA]
    Biological Process: Toll signaling pathway [NAS][TAS]
    hemocyte proliferation [TAS]
    zygotic specification of dorsal/ventral axis [IMP]
    signal transduction [IEA]
    hemopoiesis [TAS]
    protein import into nucleus [NAS]
    regulation of proteolysis [TAS]
    dorsal/ventral axis specification [TAS]
    response to fungus [TAS]
    protein amino acid phosphorylation [IEA][ISS][NAS]
    defense response [NAS][TAS]
    antifungal humoral response [IMP]
    Molecular Function: ATP binding [IEA]
    protein domain specific binding [IPI]
    protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA][ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGVQTAEAE AQAQNQANGN RTRSRSHLDN TMAIRLLPLP VRAQLCAHLD ALDVWQQLAT  60
   61 AVKLYPDQVE QISSQKQRGR SASNEFLNIW GGQYNHTVQT LFALFKKLKL HNAMRLIKDY 120
  121 VSEDLHKYIP RSVPTISELR AAPDSSAKVN NGPPFPSSSG VSNSNNNRTS TTATEEIPSL 180
  181 ESLGNIHIST VQRAAESLLE IDYAELENAT DGWSPDNRLG QGGFGDVYRG KWKQLDVAIK 240
  241 VMNYRSPNID QKMVELQQSY NELKYLNSIR HDNILALYGY SIKGGKPCLV YQLMKGGSLE 300
  301 ARLRAHKAQN PLPALTWQQR FSISLGTARG IYFLHTARGT PLIHGDIKPA NILLDQCLQP 360
  361 KIGDFGLVRE GPKSLDAVVE VNKVFGTKIY LPPEFRNFRQ LSTGVDVYSF GIVLLEVFTG 420
  421 RQVTDRVPEN ETKKNLLDYV KQQWRQNRME LLEKHLAAPM GKELDMCMCA IEAGLHCTAL 480
  481 DPQDRPSMNA VLKRFEPFVT D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..192] PSI-BLAST 6.39794 von Willebrand factor binding domain of glycoprotein Ib alpha
    2 View Details [193..501] PSI-BLAST 54.522879 No description for 2qkwB was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • receptor activity
    		•  3.26307298864411 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  3.15814977487775 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.54176035045352 bayes_pls_golite062009
  • signal transducer activity
    		•  2.54176035045352 bayes_pls_golite062009
  • G-protein coupled receptor activity
    		•  2.0521926599024 bayes_pls_golite062009
  • binding
    		•  1.87302803330255 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.62051717213565 bayes_pls_golite062009
  • kinase activity
    		•  1.58544168184546 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.44944761024618 bayes_pls_golite062009
  • protein kinase activity
    		•  1.43632437878638 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.31434688144553 bayes_pls_golite062009
  • transferase activity
    		•  1.1388404509363 bayes_pls_golite062009
  • transmembrane receptor protein kinase activity
    		•  0.6470432578516 bayes_pls_golite062009
  • protein binding
    		•  0.646159692466759 bayes_pls_golite062009
  • receptor binding
    		•  0.596307412859703 bayes_pls_golite062009
  • protein-hormone receptor activity
    		•  0.42902267001067 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.231213253402712 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.154501444195573 bayes_pls_golite062009
  • transmembrane receptor protein tyrosine kinase activity
    		•  0.120223037701308 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle